| Project/Area Number |
16H07201
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Showa Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 薬剤疫学研究 / コホート研究 / 薬剤疫学 / 薬学 |
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| Outline of Final Research Achievements |
In this study, we investigated whether the variation in genes involved in lipid metabolism modify the effect of the 3-hydroxymethyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors on serum low density lipoprotein cholesterol concentration reduction, using the information from treating physicians and pharmacies, laboratory assessments and genomic data in the Rotterdam Study in the Netherlands, a prospective population-based cohort study that aims to study the frequency and determinants of diseases in middle-aged and elderly individuals,.
We also verified the pharmacoepidemiological data from a longitudinal cohort study in Japan.
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