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Elucidate that fatigue-induced viral factors affect the onset of depression

Research Project

Project/Area Number 16H07220
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionJikei University School of Medicine

Principal Investigator

Oka Naomi  東京慈恵会医科大学, 医学部, 助教 (00704503)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsうつ病 / ウイルス / ストレス / 精神疾患 / 抗うつ薬 / ウイルス学 / ストレス脆弱性
Outline of Final Research Achievements

Small protein encoded by the intermediate stage transcript of HHV-6 (SITH-1) is a latent infected protein expressed by the human herpes virus (HHV-) 6 reactivated in a fatigue or stress-dependent manner. In order to elucidate the mechanism by which SITH-1 is involved in the development of depression, we created a SITH-1 expressing mouse model (SITH-1 mouse). SITH-1 mice showed depression-like behavior and stress vulnerability.
Further studies showed that SITH-1 expression increased intracellular calcium concentration and subsequently induced apoptosis in the olfactory bulb, resulting in inhibition of hippocampal neurogenesis. Therefore, it is considered that SITH-1 mouse had a property of impaired stress response.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (4 results)

All 2017 2016

All Presentation (3 results) Patent(Industrial Property Rights) (1 results)

  • [Presentation] 唾液中に分泌されたHHV-6がうつ病を発症させるメカニズムの解明2017

    • Author(s)
      岡直美、小林伸行、髙橋麻弓、嶋田和也、近藤一博
    • Organizer
      第13回日本疲労学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 疲労によって誘導されるウイルス因子が関与するうつ病発症メカニズムの解明2017

    • Author(s)
      岡直美、小林伸行、嶋田和也、髙橋麻弓、近藤一博
    • Organizer
      第39回生物学的精神医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 疲労によって誘導されるウイルス因子が関与するうつ病発症メカニズムの解明2016

    • Author(s)
      岡直美、小林伸行、嶋田和也、髙橋麻弓、近藤一博
    • Organizer
      第38回生物学的精神医学会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 気分障害を診断、治療又は予防する方法2016

    • Inventor(s)
      近藤一博、小林伸行、岡直美
    • Industrial Property Rights Holder
      近藤一博、小林伸行、岡直美
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-12-28
    • Related Report
      2016 Annual Research Report

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Published: 2016-09-02   Modified: 2019-03-29  

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