| Project/Area Number |
16H07238
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
Fukao Saori 東京理科大学, 研究推進機構生命医科学研究所, 研究員 (20778914)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | B細胞 / 抗体産生 / 免疫学 / 免疫応答 |
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| Outline of Final Research Achievements |
Follicular helper T (Tfh) cells produce various cytokines and regulate the isotype of antibody produced by B cells in the immune response. It is well known that various stimuli provided from B cells during T and B cells interaction are necessary for optimal Tfh cells differentiation. However, the mechanisms that control the subset of Tfh cell producing specific cytokine, IFNγ, IL-4 or IL-21 have not been fully understood.
In this study, we hypothesized that the quality of T and B cells interaction regulates the differentiation of each Tfh cell subsets and control the isotype of antibody, and then analyzed the role of B cells in the regulation of T cells differentiation.
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