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The role of Interleukin-35 in experimental periodontitis model in Ebi3 knockout mice.

Research Project

Project/Area Number 16H07316
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Periodontology
Research InstitutionAichi Gakuin University

Principal Investigator

Goto Hisashi  愛知学院大学, 歯学部, 非常勤助教 (10783037)

Research Collaborator KIKUCHI Takeshi  
OKADA Kosuke  
Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsノックアウトマウス / 実験的歯周炎 / 実験的歯周炎惹起 / 歯学
Outline of Final Research Achievements

The role of Interleukin (IL)-35 in periodontitis is not clear and the effect of IL-35 on the function of T helper 17 (Th17) cells is still incompletely understood. Therefore, we investigated the effects of IL-35, undertaken to compare experimental periodontitis induced by Porphyromonas gingivalis, clearly associated with the pathogenesis of periodontitis in Ebi3 knockout (KO) mice and wild-type (WT) mice. Computed tomography(CT) analysis and hematoxylin-and-eosin (H&E) and tartrate-resistant acid phosphatase (TRAP) staining were performed. Alveolar bone resorption was seen around the first and second mandibular molars in P.gingivalis-infected WT mice or in infected KO mice. Furthermore, infected Ebi3 KO mice alveolar bone resorption fenestration was higher than any other groups. Histological analysis of mandibles from Ebi3 KO and WT mice did not show clearly difference in the elements characteristic of periodontal tissues.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report

URL: 

Published: 2016-09-02   Modified: 2019-03-29  

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