| Project/Area Number |
16H07322
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Genome biology
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| Research Institution | National Center for Geriatrics and Gerontology (2017)
Nagahama Institute of Bio-Science and Technology (2016) |
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Principal Investigator |
KAMEI Yuka 国立研究開発法人国立長寿医療研究センター, 老化機構研究部, 流動研究員 (90772153)
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| Research Collaborator |
MUKAI Yukio 長浜バイオ大学, バイオサイエンス学部, 准教授 (60252615)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ビタミンB6 / 細胞寿命 / 分裂寿命 / アミノ酸 / 出芽酵母 |
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| Outline of Final Research Achievements |
We found that vitamin B6 (VB6) sustain replicative lifespan in yeast. However, how VB6 regulates cellular lifespan is unclear. VB6 synthase was found to be upregulated in early senescent cells. Two nutrient-regulated transcription factors were independently required for the VB6 synthase upregulation and longevity. We observed a VB6-dependent metabolic difference and characteristic amino acid changes. A lot of deletion mutants of VB6-dependent enzyme gene exhibited short lifespan. These results indicate that VB6 deficiency accelerates cellular ageing due to a combination of metabolic defects and provide valuable information for understanding cellular anti-ageing by VB6 in higher eukaryotes.
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