| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Preceding studies showed that α-synuclein (α-syn) was accumulated in neurons and extracellular α-syn bound to microglia and caused inflammation in the brain of patients with synucleinopathy. In this study, I investigated the effects of DJ-1 which is one of the causative genes of Parkinson's disease to cell responses induced by α-syn. I revealed that intracellular aggregation of α-syn was increased in the DJ-1 deficient SH-SY5Y cells compared with WT cells. Furthermore, I found that compounds predicted to bind to DJ-1 attenuated the inflammatory response in Microglia. These data suggest that DJ-1 can be a therapeutic target for neurodegenerative disease caused by α-syn.
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