| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The ectopic expression of MIR34a significantly inhibited the cancer cell growth through the induction of autophagy in gastric cancer (GC) cells. The production of lactate and the up-take of glucose were decreased in MIR34a-treated GC cells through the down-regulation of the expression levels of SLC2A1 and LDHA. Also, the expression levels of LDHA and SLC2A1 were up-regulated in clinical GC samples. Our findings implied that dysregulation of MIR34a-expression affect the acquisition of the Warburg effect in GC cell. Additionally, we revealed that RNA-helicase DDX6 promote GC development by regulation of MYC. Also, we detected new PTBP1-associated miRNAs. Our findings in this project were very important for innovative drug development which targets the Warburg effect.
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