Elucidation of cancer specific energy metabolism by MIR34a and clinical application of it.
Project/Area Number |
16H07344
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Digestive surgery
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Research Institution | Osaka Medical College |
Principal Investigator |
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Project Period (FY) |
2016-08-26 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | microRNA / Warburg 効果 / MIR34a / GLUT1 / LDHA / MYC / miR-34a / ワーバーグ効果 / 胃がん / miR-34a / Warburg効果 / エネルギー代謝 |
Outline of Final Research Achievements |
The ectopic expression of MIR34a significantly inhibited the cancer cell growth through the induction of autophagy in gastric cancer (GC) cells. The production of lactate and the up-take of glucose were decreased in MIR34a-treated GC cells through the down-regulation of the expression levels of SLC2A1 and LDHA. Also, the expression levels of LDHA and SLC2A1 were up-regulated in clinical GC samples. Our findings implied that dysregulation of MIR34a-expression affect the acquisition of the Warburg effect in GC cell. Additionally, we revealed that RNA-helicase DDX6 promote GC development by regulation of MYC. Also, we detected new PTBP1-associated miRNAs. Our findings in this project were very important for innovative drug development which targets the Warburg effect.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Oncogene RNA helicase DDX6 promotes the process of c-Myc expression in gastric cancer cells.2018
Author(s)
Taniguchi K, Iwatsuki A, Sugito N, Shinohara H, Kuranaga Y, Oshikawa Y, Tajirika T, Futamura M, Yoshida K, Uchiyama K, Akao Y.
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Journal Title
Molecular Carcinogenesis
Volume: 57(5)
Issue: 5
Pages: 579-589
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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