| Project/Area Number |
16H07361
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Applied health science
|
|---|
| Research Institution | Osaka University of Human Sciences |
|---|
Principal Investigator |
Tanaka Masayuki 大阪人間科学大学, 人間科学部, 助教 (10780497)
|
|---|
| Project Period (FY) |
2016-08-26 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 糖尿病 / 骨格筋 / 筋萎縮 / サルコペニア / 抗酸化物質 / ミトコンドリア機能障害 / 食品 / 栄養 |
|---|
| Outline of Final Research Achievements |
The purpose of the present study was to investigate the effect of antioxidant astaxanthin supplementation on skeletal muscle loss and mitochondrial dysfunction in diabetic rats. Streptozotocin-induced diabetic rats exhibited the muscle atrophy, decrease in rpS6 phosphorylation, increase in Bax/Bcl-2 ratio, decrease in XIAP protein expression and decrease in CS activity and PGC-1α protein expression. On the other hand, the antioxidant astaxanthin supplementation lessened or prevented these changes in the diabetic muscle. These results suggested that astaxanthin supplementation could attenuate diabetes-related muscle atrophy and mitochondrial dysfunction and that it might be effective countermeasure for muscle atrophy and decrement in muscle oxidative metabolism associated with diabetes.
|
