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Development of nutrients to prevent skeletal muscle loss induced by diabetes

Research Project

Project/Area Number 16H07361
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Applied health science
Research InstitutionOsaka University of Human Sciences

Principal Investigator

Tanaka Masayuki  大阪人間科学大学, 人間科学部, 助教 (10780497)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords糖尿病 / 骨格筋 / 筋萎縮 / サルコペニア / 抗酸化物質 / ミトコンドリア機能障害 / 食品 / 栄養
Outline of Final Research Achievements

The purpose of the present study was to investigate the effect of antioxidant astaxanthin supplementation on skeletal muscle loss and mitochondrial dysfunction in diabetic rats. Streptozotocin-induced diabetic rats exhibited the muscle atrophy, decrease in rpS6 phosphorylation, increase in Bax/Bcl-2 ratio, decrease in XIAP protein expression and decrease in CS activity and PGC-1α protein expression. On the other hand, the antioxidant astaxanthin supplementation lessened or prevented these changes in the diabetic muscle. These results suggested that astaxanthin supplementation could attenuate diabetes-related muscle atrophy and mitochondrial dysfunction and that it might be effective countermeasure for muscle atrophy and decrement in muscle oxidative metabolism associated with diabetes.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (2 results)

All 2017

All Presentation (2 results)

  • [Presentation] 糖尿病に伴う筋萎縮に対するアスタキサンチン摂取の効果2017

    • Author(s)
      田中雅侑, 金指美帆,藤野英己
    • Organizer
      第72回日本体力医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 2型糖尿病に伴う骨格筋毛細血管構造の破綻に対するアスタキサンチンの抑制効果2017

    • Author(s)
      金指美帆,田中雅侑,中西亮介,藤野英己
    • Organizer
      第72回日本体力医学会
    • Related Report
      2017 Annual Research Report

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Published: 2016-09-02   Modified: 2019-03-29  

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