| Project/Area Number |
16H07388
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 矯正歯科 / 線維芽細胞 / 口蓋裂 / 瘢痕組織 / microfibril / TGF / MAGP-1 / 微細線維 / EMILIN / Fibulin / 術後口蓋瘢痕 / TGF-β / 歯学 / Fibrillin-1 / EMILIN-1 / 口蓋線維芽細胞 / 細胞伸展培養 / SMAD-2/3 / 1型コラーゲン / 瘢痕形成抑制 |
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| Outline of Final Research Achievements |
Cleft palate surgery suppresses the growth of the maxilla and makes it difficult to align the teeth. In order to cure surgical wounds, fibroblasts produce a large amount of collagen by anti-inflammatory cytokine TGF-β and form scars. Recently, it was reported that TGF-β is suppressed by binding to MAGP-1 which forms microfibril in somatic connective tissue. Therefore, it was thought that administeration of MAGP-1 to cleft surgical wounds could inhibit scar formation. Currently, we have prepared an in-vitro scar model with human gingival fibroblasts cultured in extensible mechanical stimulation, and found that the cells significantly increase MAGP-1 gene expression by extensible mechanical stimulation.
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