Research Project
Grant-in-Aid for Research Activity Start-up
Chromosome ploidy has diversified during evolution in all of the three domains of life, bacteria, archaea, and eukaryotes. Cyanobacteria (and chloroplast) maintain multiple copies of chromosomes (genomes). Although a correlation between ploidy level and cell size has been observed in bacteria and eukaryotes, it is poorly understood how replication of multi-copy chromosomes is regulated and how ploidy level is adjusted to cell size. Here we show that only one (or a few) copy of multiple chromosomes is replicated at once in the cyanobacteria and that this restriction depends on regulation of DnaA activity. Moreover, when cell growth rate was increased or decreased at a constant temperature, DnaA level, DnaA activity, and the number of replicating chromosomes also increased or decreased, resulting in nearly constant chromosome copy number per unit cell volume.
All 2018 2017
All Journal Article (4 results) (of which Peer Reviewed: 4 results, Open Access: 3 results, Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Invited: 1 results)
Microbiology
Volume: 164 Issue: 1 Pages: 45-56
10.1099/mic.0.000577
Front. Plant Sci.
Volume: 8 Pages: 343-343
10.3389/fpls.2017.00343
Proc. Natl. Acad. Sci. USA.
Volume: 114 Issue: 39
10.1073/pnas.1707072114
Plant and Cell Physiology
Volume: 58 (2) Pages: 279-286
10.1093/pcp/pcw186
