| Project/Area Number |
16H07432
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Integrative animal science
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| Research Institution | National Institute for Environmental Studies |
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Principal Investigator |
Katayama Masafumi 国立研究開発法人国立環境研究所, 生物・生態系環境研究センター, 特別研究員 (80784090)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 不死化細胞 / 鳥類 / 感染症評価系 / 鳥インフルエンザ / 染色体不安定性 / 感染症評価 / 細胞周期 / インフルエンザ |
|---|
| Outline of Final Research Achievements |
In this study, we tried to establish the wild avian derived immortalized cell line. The avian derived immortalized cell is rare, therefore establishment is not easy. To establish the immortalized cell, we used three genes (CDK4, CyclinD and TERT). The avian derived cells were increased cell division number by that of three genes, but did not immortalize. So we concluded that that of three genes are partially avoid the cellular senescence in the avian cells. Additionally, we obtained wild avian derived immortalized cells from three genes transfected avian cells. It's a very unique cells, because, as far as our knowledge, this is first report of wild avian derived immortalized cells.
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