| Project/Area Number |
16H07463
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
MORIYA Yuki 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 研究員 (50783528)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | オピオイド受容体 / 依存性薬物 / 性差 / Addictive Disorders / Sex differences / alcoholic / アルコール依存 / 薬物依存 / μオピオイド受容体 / κオピオイド受容体 / δオピオイド受容体 / オピオイド受容体欠損マウス / 雌雄差 / アルコール摂取 / ストレス / μオピオイド受容体欠損マウス / 社会的敗北ストレス / 拘束ストレス / オピオイド / 依存性物質 / 脳内微小透析法 |
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| Outline of Final Research Achievements |
A complex relationship exists between alcohol-drinking behavior and stress. There are well-known sex differences in the epidemiology of alcohol dependence; however, the relationship between stress and alcohol consumption is poorly understood. This study assessed the effects of restrain stress on later ethanol intake using a two-bottle home-cage consumption (ethanol 8% vs. water) paradigm in WT and mu-opioid knockout mice. Restraint stress modestly increased ethanol consumption in female mu-opioid knockout mice but not in female and male wild-type mice. The locomotor activity with forced alcohol drinking among male and female wild-type and mu-opioid knockout mice were not significantly different.
The study shows that disturbances of mu-opioid receptors influences the behavioral consequences of ethanol consumption following stress in a sex-dependent manner.
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