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The relationship between stress and substance dependence in opioid receptor knockout mice.

Research Project

Project/Area Number 16H07463
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Applied pharmacology
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

MORIYA Yuki  公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 研究員 (50783528)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsオピオイド受容体 / 依存性薬物 / 性差 / Addictive Disorders / Sex differences / alcoholic / アルコール依存 / 薬物依存 / μオピオイド受容体 / κオピオイド受容体 / δオピオイド受容体 / オピオイド受容体欠損マウス / 雌雄差 / アルコール摂取 / ストレス / μオピオイド受容体欠損マウス / 社会的敗北ストレス / 拘束ストレス / オピオイド / 依存性物質 / 脳内微小透析法
Outline of Final Research Achievements

A complex relationship exists between alcohol-drinking behavior and stress. There are well-known sex differences in the epidemiology of alcohol dependence; however, the relationship between stress and alcohol consumption is poorly understood. This study assessed the effects of restrain stress on later ethanol intake using a two-bottle home-cage consumption (ethanol 8% vs. water) paradigm in WT and mu-opioid knockout mice. Restraint stress modestly increased ethanol consumption in female mu-opioid knockout mice but not in female and male wild-type mice. The locomotor activity with forced alcohol drinking among male and female wild-type and mu-opioid knockout mice were not significantly different.
The study shows that disturbances of mu-opioid receptors influences the behavioral consequences of ethanol consumption following stress in a sex-dependent manner.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (8 results)

All 2018 2017 2016 Other

All Presentation (7 results) (of which Int'l Joint Research: 5 results) Remarks (1 results)

  • [Presentation] 薬理学的解析支援を利用する利点2018

    • Author(s)
      森屋由紀, 西澤大輔, 井手聡一郎, 池田和隆
    • Organizer
      平成29年度新学術領域研究 学術研究支援基盤形成「先端モデル動物支援プラットフォーム」成果発表
    • Related Report
      2017 Annual Research Report
  • [Presentation] The relationship between stress and alcohol consumption in female mice.2017

    • Author(s)
      Yuki Moriya, Yoshiyuki Kasahara, F.Scott Hall, George R. Uhl, Kazutaka Ikeda, Ichiro Sora
    • Organizer
      5th Asian College of Neuropsychopharmacology (AsCNP)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sex differences in drinking behavior following stress in mu-opioid receptor knockout mice2017

    • Author(s)
      Yuki Moriya, Yoshiyuki Kasahara, F.Scott Hall, George R. Uhl, Kazutaka Ikeda, Ichiro Sora
    • Organizer
      Society for Neuroscience (SfN) 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effects of chronic stress on alcohol consumption in μ-opioid receptor knockout mice.2017

    • Author(s)
      Yuki Moriya, Yoshiyuki Kasahara, F.Scott Hall, George R. Uhl, Kazutaka Ikeda, Ichiro Sora.
    • Organizer
      International Narcotics Research Conference 2017 (INRC)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Methamphetamine induced changes of monoamine neurotransmission in 5-HT1B KO mice2016

    • Author(s)
      Yuki Moriya, Yoshiyuki Kasahara, Yoko Hagino, F. Scott Hall, Rene Hen, Kazutaka Ikeda, George R. Uhl, Ichiro Sora
    • Organizer
      The 30th International College of Neuropsychopharmacology (CINP)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sex differences in voluntary drinking by μ-opioid receptor knockout mice following early stress2016

    • Author(s)
      Yuki Moriya, Yoshiyuki Kasahara, F.Scott Hall, George R. Uhl, Kazutaka Ikeda, Ichiro Sora
    • Organizer
      International Narcotics Research Conference 2016 (INRC)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 性差の観点からみたストレスによるアルコール摂取行動変化とμオピオイド神経伝達系の関与2016

    • Author(s)
      森屋 由紀, 笠原 好之, F. Scott Hall, George R.Uhl,曽良 一郎, 池田 和隆
    • Organizer
      平成28年度【先端モデル動物支援プラットフォーム】若手支援技術講習会
    • Related Report
      2016 Annual Research Report
  • [Remarks] 依存性薬物プロジェクト Addictive Substance Project

    • URL

      http://www.igakuken.or.jp/project/detail/abuse.html

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report

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Published: 2016-09-02   Modified: 2019-03-29  

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