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Construction of polymeric micelle with thermo-responsive poly(amino acid)s

Research Project

Project/Area Number 16H07494
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionKawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine

Principal Investigator

Hayashi Kotaro  公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 研究員 (00780660)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsバイオマテリアル / 機能性高分子 / 核酸デリバリー / 核酸医薬
Outline of Final Research Achievements

Although antisense oligonucleotides, which selectively suppress genes overexpressed in intractable diseases, have been expected as next molecular targeting drugs, therapeutic use of them was limited due to poor accumulation into target tissues or cells. Delivery system of them has been researched to overcome the hurdle. Herein, I synthesized poly(amino acid) based thermo-responsible polymer for polymeric nanomicelles, directing to stabilization of nanoparticles by additional protective layer under intravital circumstance. Synthesized poly(amino acid) polymer exhibited phase transition around 25 degree. This polymer was expected as biocompatible materials for highly-functionalized delivery carrier design for effective accumulation into target tissues.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (5 results)

All 2018 2017 2016

All Presentation (4 results) (of which Int'l Joint Research: 2 results) Patent(Industrial Property Rights) (1 results)

  • [Presentation] RNA鎖と重合度の異なるカチオン性ブロック共重合体の会合挙動の解析2017

    • Author(s)
      林光太朗、福島重人、長田健介、西山伸宏、宮田完二郎、片岡一則
    • Organizer
      第66回高分子学会年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effect of ionomer rigidity on the complex formation with block-catiomer and RNAs2017

    • Author(s)
      Kotaro Hayashi, Shigeto Fukushima, Hiroyasu Takemoto, Kensuke Osada, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
    • Organizer
      253rd ACS National meeting & Exposition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Control of nanoparticle assembly between nucleic acid and block-catiomer2016

    • Author(s)
      Kotaro Hayashi
    • Organizer
      3rd International Conference on Biomaterials Science in Tokyo
    • Place of Presentation
      The University of Tokyo
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] siRNAとブロック共重合体のイオン性会合体における会合数の制御2016

    • Author(s)
      林光太朗
    • Organizer
      第65回高分子討論会
    • Place of Presentation
      神奈川大学
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 刺激応答性ポリマー2018

    • Inventor(s)
      林光太朗、片岡一則
    • Industrial Property Rights Holder
      川崎市産業振興財団
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report

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Published: 2016-09-02   Modified: 2019-03-29  

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