| Project/Area Number |
16H07494
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine |
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Principal Investigator |
Hayashi Kotaro 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 研究員 (00780660)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | バイオマテリアル / 機能性高分子 / 核酸デリバリー / 核酸医薬 |
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| Outline of Final Research Achievements |
Although antisense oligonucleotides, which selectively suppress genes overexpressed in intractable diseases, have been expected as next molecular targeting drugs, therapeutic use of them was limited due to poor accumulation into target tissues or cells. Delivery system of them has been researched to overcome the hurdle. Herein, I synthesized poly(amino acid) based thermo-responsible polymer for polymeric nanomicelles, directing to stabilization of nanoparticles by additional protective layer under intravital circumstance. Synthesized poly(amino acid) polymer exhibited phase transition around 25 degree. This polymer was expected as biocompatible materials for highly-functionalized delivery carrier design for effective accumulation into target tissues.
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