| Project/Area Number |
16H07498
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | Department of Clinical Research, National Hospital Organization Kyoto Medical Center |
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Principal Investigator |
Inoue Takayuki 独立行政法人国立病院機構(京都医療センター臨床研究センター), 内分泌代謝高血圧研究部, 研究員 (50581386)
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| Research Collaborator |
ASAHARA Noriko (SATOH Noriko) 国立病院機構京都医療センター, 臨床研究センター 内分泌代謝高血圧研究部, 研究部長
Otani Hiroki 島根大学, 医学解剖学講座, 発生生物学教授
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 生活習慣病 / 慢性炎症 / 脂肪酸 / ミクログリア / 骨格筋 / DOHaD / DOHaD概念 / ω3不飽和脂肪酸 / オメガ3不飽和脂肪酸 / 脳内炎症 / 筋力低下 |
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| Outline of Final Research Achievements |
Cerebral inflammation is exacerbated in obese/diabetic conditions, and microglia is the main cell type for neuroinflammation. In the present study, we demonstrated that omega-3 polyunsaturated fatty acids exhibited the novel anti-inflammatory effects on microglia through stimulating SIRT1-mediated pathway. Additionally, we found that CXC chemokine-ligand-1 (CXCL1), a myokine, was elevated in skeletal muscle cells by obese stimuli in which the skeletal muscle regeneration was reportedly aggravated. We further demonstrated that the elevated CXCL1 was implicated in promoting myogenesis, thereby suggesting the novel functional significance of CXCL1 in maintaining skeletal muscle mass despite obese conditions. These findings would contribute to development of effective nutrition guidance and novel therapeutic strategies for prevention/improvement of obesity/diabetes-related diseases including cognitive impairment and muscle atrophy.
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