Analysis of a regulatory mechanism of directional migration of endothelial tip cells during angiogenesis by bioimaging

Research Project

Project/Area Number	16H07499
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	General physiology
Research Institution	National Cardiovascular Center Research Institute
Principal Investigator	Wakayama Yuki 国立研究開発法人国立循環器病研究センター, 研究所, 流動研究員 (70782853)
Project Period (FY)	2016-08-26 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	血管新生 / VEGFR2 / ゼブラフィッシュ / 蛍光イメージング / 一方向性移動 / 蛍光生体イメージング / 発生・分化 / 細胞・組織 / シグナル伝達
Outline of Final Research Achievements	Angiogenesis is the process to form new blood vessels. In this study, I investigated the regulatory mechanism of endothelial cell migration by bioimaging technique. It is suggested that Vascular endothelial growth factor receptor 2 (VEGFR2) is transported by KIF13B, a molecular motor, to the leading edge in leader cells. And I found that cell adhesion is important for endothelial cell migration.

Report

(3 results)