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ウイルスゲノムの特徴量解析と自然宿主推定への応用

Research Project

Project/Area Number 16J02715
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section国内
Research Field Life / Health / Medical informatics
Research InstitutionHokkaido University

Principal Investigator

Tessmer Heidi Lynn (2017)  北海道大学, 獣医学研究科, 特別研究員(DC2)

TESSMER HEIDI LYNN (2016)  北海道大学, 獣医学研究科, 特別研究員(DC2)

Project Period (FY) 2016-04-22 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2017: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2016: ¥700,000 (Direct Cost: ¥700,000)
Keywords機械学習 / 感染症 / 基本再生産数 / infectious disease / machine learning / mathematical modeling / epidemiology
Outline of Annual Research Achievements

I continued my research into machine learning, including server maintenance and optimization, learning and using different ML libraries, attending conferences, and exploring the latest papers, tutorials, and industry standards.
Two co-authored papers:
- Tessmer HL, Ito K, and Omori R. Can machines learn respiratory virus epidemiology?: A comparative study of likelihood-free methods for the estimation of epidemiological dynamics.
- Sakon N, Komano J, Tessmer HL, and Omori R. High transmissibility of norovirus among infants and school children during the 2016/17 season in Osaka, Japan.
Abstract: To estimate and predict the transmission dynamics of respiratory viruses, the estimation of the basic reproduction number, R0, is essential. Recently, approximate Bayesian computation methods have been used as likelihood free methods to estimate epidemiological model parameters, particularly R0. In this paper, we explore various machine learning approaches, the multi-layer perceptron, convolutional neural network, and long-short term memory, to learn and estimate the parameters. Further, we compare the accuracy of the estimates and time requirements for machine learning and the approximate Bayesian computation methods on both simulated and real-world epidemiological data from outbreaks of influenza A(H1N1)pdm09, mumps, and measles. We find that the machine learning approaches can be verified and tested faster than the approximate Bayesian computation method, but that the approximate Bayesian computation method is more robust across different datasets.

Research Progress Status

29年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

29年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (6 results)

All 2018 2016 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Int'l Joint Research] Seoul National University(韓国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Can Machines Learn Respiratory Virus Epidemiology?: A Comparative Study of Likelihood-Free Methods for the Estimation of Epidemiological Dynamics2018

    • Author(s)
      Tessmer Heidi L.、Ito Kimihito、Omori Ryosuke
    • Journal Title

      Frontiers in Microbiology

      Volume: 9 Pages: 343-343

    • DOI

      10.3389/fmicb.2018.00343

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High transmissibility of norovirus among infants and school children during the 2016/17 season in Osaka, Japan2018

    • Author(s)
      Sakon Naomi、Komano Jun、Tessmer Heidi L.、Omori Ryosuke
    • Journal Title

      Eurosurveillance

      Volume: 23 Issue: 6 Pages: 29-29

    • DOI

      10.2807/1560-7917.es.2018.23.6.18-00029

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tracking the evolution of polymerase genes of influenza A viruses during interspecies transmission between avian and swine hosts2016

    • Author(s)
      Karnbunchob N, Omori R, Tessmer H, Ito K
    • Journal Title

      Front Microbiol

      Volume: 7 Pages: 2118-2118

    • DOI

      10.3389/fmicb.2016.02118

    • NAID

      120005955478

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Estimating the Lineage Dynamics of Human Influenza B Viruses2016

    • Author(s)
      Mayumbo Nyirenda, Ryosuke Omori, Heidi L. Tessmer, Hiroki Arimura, Kimihito Ito
    • Journal Title

      PLoS ONE

      Volume: 11(11) Issue: 11 Pages: e0166107-e0166107

    • DOI

      10.1371/journal.pone.0166107

    • NAID

      120005946864

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Estimation of Basic Reproduction Number R0 using a Recurrent Neural Network2016

    • Author(s)
      Tessmer HL and Omori R
    • Organizer
      NIPS 2016 Workshop on Machine Learning for Health
    • Place of Presentation
      Centre Convencions Internacional Barcelona, Barcelona, SPAIN
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research

URL: 

Published: 2016-05-17   Modified: 2024-03-26  

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