| Project/Area Number |
16J04075
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Single-year Grants |
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| Section | 国内 |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | Kyushu University |
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Principal Investigator |
Tran Thi Thao Nguyen (2017-2018) 九州大学, 医学系学府, 特別研究員(DC1)
TRAN THI THAO NGUYEN (2016) 九州大学, 医学系学府, 特別研究員(DC1)
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| Project Period (FY) |
2016-04-22 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2018: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2017: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2016: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | Cold spots / IMRT / VMAT / Prostate cancer / Cervical cancer / Brachytherapy / Heterogeneous materials / Monte Carlo simulation / 3D gamma analysis / Applicator |
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| Outline of Annual Research Achievements |
Small volumes of low dose regions (cold spots) in the target volume in prostate cancer treatment could cause recurrence of tumors. This study aimed to compare volumetric-modulated arc therapy (VMAT) with intensity-modulated radiation therapy (IMRT) accounting for cold spots in prostate cancer plans. The basic idea was to evaluate dosimetric indices for the planning target volume (PTV) and organs at risk (OAR), and analyze cold spots (numbers and volumes) of the PTV and the region in which the rectum overlapped with the PTV (ROP) region for VMAT and IMRT plans. Three-dimensional probabilistic distributions of cold spots were also generated using a centroid matching technique for visualization and analysis. The differences between the VMAT and IMRT plans were evaluated using two-sided paired Student’s t-test. Compared with IMRT, the VMAT plans achieved better PTV dose conformity, OAR dose-sparing, and smaller cold spots in the treatment of prostate cancer.
This research has been published in the Radiological Physics and Technology (RPT), 2019.02, (https://doi.org/10.1007/s12194-019-00502-0).
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| Research Progress Status |
平成30年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
平成30年度が最終年度であるため、記入しない。
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