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競技アスリートの減量後の回復法と安定同位体標識クレアチンによる骨格筋量測定の検証

Research Project

Project/Area Number 16J11877
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section国内
Research Field Sports science (A)
Research InstitutionNational Agency for the Advancement of Sports and Health
Research Fellow 下山 寛之  独立行政法人日本スポーツ振興センター国立スポーツ科学センター, スポーツ研究部, 特別研究員(PD) (80760652)
Project Period (FY) 2016-04-22 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords骨格筋量 / 安定同位体 / 基礎代謝 / 身体組成 / 水分代謝 / アスリート / エネルギー代謝 / MRI / 体重階級制競技
Outline of Annual Research Achievements

研究の目的は(1)アスリートの為の正確かつ簡便な安定同位体標識クレアチン(D3-creatine)を用いた骨格筋評価方法の妥当性の検証,(2)安定同位体を用いたアスリートの1 日の水分摂取量の基準値づくり,(3)安定同位体を用いた減量後の回復(リフィーディング)による基質の取り込みとその消費のタイミング,食事構成比の影響を検討することである.
主な研究目的であるアスリートのための正確かつ簡便な安定同位体標識クレアチン (D3-creatine)を用いた骨格筋評価方法の妥当性の検証のために31名のサンプルを取得した.取得された安定同位体サンプルおよび全身MRI画像は分析中である.同時に,この研究で取得している水分代謝,基礎代謝,その他身体組成評価法(生体電気インピーダンス法,DXA法,同位体希釈法,多成分モデル)のデータ解析も,他の研究機関と協力し解析する予定である.
水分摂取量の基準値づくりの為の水分代謝のデータも蓄積されてきており,これまでに,卓球,レスリング,水泳,セーリング,陸上など40名以上の様々な競技や季節変動に係る変数を取得できている為,水分摂取量推定のための数理モデルの検討,作成を行う予定である.また,13Cの安定同位体で標識された糖質を用いて特定の飲料水をラベル化し,基質代謝の基礎的なデータを得ることが出来たため,今後,炭素核磁気共鳴分光(13C-MRS)法と組み合わせ骨格筋までの取り込みをトレースできるように方法論を確立させ,発展させたい.

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Report

(3 results)
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report

Research Products

(32 results)

All 2019 2018 2017 2016 Other

All Journal Article (11 results) (of which Peer Reviewed: 9 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (19 results) (of which Int'l Joint Research: 11 results,  Invited: 1 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Effective Timing of Curcumin Ingestion to Attenuate Eccentric Exercise-Induced Muscle Soreness in Men2019

    • Author(s)
      Tanabe Yoko、Chino Kentaro、Sagayama Hiroyuki、Lee Hyun Jin、Ozawa Hitomi、Maeda Seiji、Takahashi Hideyuki
    • Journal Title

      J Nutr Sci Vitaminol

      Volume: 65 Issue: 1 Pages: 82-89

    • DOI

      10.3177/jnsv.65.82

    • NAID

      130007605073

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Thoracic Gas Volume Changes on Body Composition Assessed by Air Displacement Plethysmography after Rapid Weight Loss and Regain in Elite Collegiate Wrestlers2019

    • Author(s)
      Kondo Emi、Shiose Keisuke、Yamada Yosuke、Osawa Takuya、Sagayama Hiroyuki、Motonaga Keiko、Ouchi Shiori、Kamei Akiko、Nakajima Kohei、Takahashi Hideyuki、Okamura Koji
    • Journal Title

      Sports

      Volume: 7 Pages: 48-48

    • DOI

      10.3390/sports7020048

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation2019

    • Author(s)
      Tanabe Yoko、Chino Kentaro、Ohnishi Takahiro、Ozawa Hitomi、Sagayama Hiroyuki、Maeda Seiji、Takahashi Hideyuki
    • Journal Title

      Scandinavian Journal of Medicine & Science in Sports

      Volume: 29 Pages: 524-534

    • DOI

      10.1111/sms.13373

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of rapid weight loss and 3-h recovery on energy expenditure, carbohydrate, and fat oxidation in boxing athletes2019

    • Author(s)
      Hiroyuki Sagayama、Eiichi Yoshimura、Yosuke Yamada、Hiroaki Tanaka
    • Journal Title

      The Journal of Sports Medicine and Physical Fitness

      Volume: 6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 基礎代謝・スポーツ活動に伴う代謝の変化 (特集 現場で使えるスポーツ栄養学) -- (栄養学の基礎)2018

    • Author(s)
      近藤 衣美、下山 寛之
    • Journal Title

      臨床スポーツ医学

      Volume: 35 Pages: 1128-1133

    • NAID

      40021716035

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 水分・電解質 水分とエネルギー補給 (特集 現場で使えるスポーツ栄養学)2018

    • Author(s)
      下山 寛之、内藤 貴司
    • Journal Title

      臨床スポーツ医学

      Volume: 35 Pages: 1148-1154

    • NAID

      40021716286

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Effect of health tourism weight loss program on body composition and health outcomes in healthy and excess-weight adults.2018

    • Author(s)
      Sagayama H, Shizuma K, Toguchi M, Mizuhara H, Machida Y, Yamada Y, Ebine N, Higaki Y, Tanaka H
    • Journal Title

      Br J Nutr

      Volume: 119 Pages: 1133-1141

    • DOI

      10.1017/s0007114518000582

    • Description
      in print
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 短期間減量プログラムにおける運動介入と高たんぱく質に設定した低炭水化物食または高炭水化物食による食事制限が身体組成に与える影響2018

    • Author(s)
      下山寛之、渡口槙子、安方惇、山﨑郁美、嶋田康平、廣田貴也、山田陽介、海老根直之、布目寛幸、清永明、桧垣靖樹、田中宏暁
    • Journal Title

      日本スポーツ栄養研究誌

      Volume: 11 Pages: 12-24

    • NAID

      40021470906

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Energy Requirement Assessment in Japanese Table Tennis Players Using the Doubly Labeled Water Method.2017

    • Author(s)
      Sagayama H, Hamaguchi G, Toguchi M, Ichikawa M, Yamada Y, Ebine N, Higaki Y, Tanaka H
    • Journal Title

      Int J Sport Nutr Exerc Metab

      Volume: 27 Pages: 421-428

    • DOI

      10.1123/ijsnem.2017-0022

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Energy requirement assessment and water turnover in Japanese college wrestlers using the doubly labeled water method2017

    • Author(s)
      Sagayama H, Kondo E, Shiose K, Yamada Y, Motonaga K, Ouchi S, Kamei A, Osawa T, Nakajima K, Takahashi H, Higaki Y, Tanaka H.
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 印刷中

    • NAID

      130005680626

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Segmental extracellular and intracellular water distribution and muscle glycogen after 72-h carbohydrate loading using spectroscopic techniques2016

    • Author(s)
      Shiose K, Yamada Y, Motonaga K, Sagayama H, Higaki Y, Tanaka H, Takahashi H.
    • Journal Title

      Journal of Applied Physiology

      Volume: 121(1) Pages: 205-211

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 脊髄損傷アスリートに活用できる基礎代謝量推定式の検討2019

    • Author(s)
      元永恵子, 山田陽介, 吉田司, 近藤衣美, 中潟崇, 下山寛之,吉野昌恵, 袴田智子, 山本真帆, 高橋英幸, 半谷美夏, 緒方徹
    • Organizer
      第28回日本障がい者スポーツ学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 運動と食事による短期的な減量介入がアスリートの身体組成とランニングパフォーマンスに及ぼす影響2018

    • Author(s)
      高江理恵,畑本陽一,山本泰輝,田上友季也,下山寛之,山田陽介,海老根直之,檜垣靖樹,田中宏暁.
    • Organizer
      第73回日本体力医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 午前中の高強度運動後の仮眠が午後のパフォーマンスに及ぼす影響2018

    • Author(s)
      安藤加里菜, 下山寛之, 高橋将記, 柴田重信, 星川雅子, 高橋英幸.
    • Organizer
      第73回日本体力医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 観光資源を利用した減量を目的とする運動・食事指導の効果2018

    • Author(s)
      下山寛之, 渡口槙子, 静間佳代子, 水原博而, 桧垣靖樹, 田中宏暁.
    • Organizer
      第73回日本体力医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 急速減量後の高炭水化物食が筋グリコーゲンおよび運動パフォーマンスの回復に及ぼす影響2018

    • Author(s)
      近藤衣美, 塩瀬圭佑, 西牧未央, 山下大地, 元永恵子, 下山寛之, 亀井明子, 中嶋耕平, 西口茂樹, 高橋英幸.
    • Organizer
      第73回日本体力医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 多周波生体電気インピーダンス分光法を用いた日本人レスリング選手の体水分量推定の妥当性2018

    • Author(s)
      塩瀬圭佑, 近藤衣美, 山田陽介, 下山寛之, 元永恵子, 亀井明子, 中嶋耕平, 高橋英幸.
    • Organizer
      第5回日本スポーツ栄養学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Ice slurry ingestion during break times attenuates the increase of core temperature in simulated match-play tennis in the heat2018

    • Author(s)
      Naito T, Sagayama H, Akazawa N, Haramura M, Tasaki M, Takahashi H.
    • Organizer
      The 23th Annual Congress of the European College of Sports Science (ECSS)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effects of exercise and napping on overnight sleep2018

    • Author(s)
      Ando K, Sagayama H, Takahashi M, Shibara S, Hoshikawa M, Takahashi H.
    • Organizer
      The 30th Society for Light Treatment and Biological Rhythms (SLTBR)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] レスリング選手におけるトレーニング期の総エネルギー消費量,身体活動レベルおよび水分代謝2017

    • Author(s)
      下山寛之、近藤衣美、塩瀬圭佑、山田陽介、元永恵子、大内志織、亀井明子、大澤拓也、中嶋耕平、髙橋英幸、桧垣靖樹、田中宏暁
    • Organizer
      第72回日本体力医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 地域在住高齢者の身体活動量と体力の関係2017

    • Author(s)
      安方惇、下山寛之、桧垣靖樹、田中宏暁
    • Organizer
      第66回九州体育・スポーツ学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Investigation of the constrained model for total energy expenditure in athletes2017

    • Author(s)
      Sagayama Hiroyuki、Schoeller A Dale
    • Organizer
      4th International Recent Advances and Controversies in Measurement of Energy Metabolism (RACMEM)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Application of stable isotopes for athletes and energy imbalance situation2017

    • Author(s)
      Hiroyuki Sagayama
    • Organizer
      4th International Recent Advances and Controversies in Measurement of Energy Metabolism (RACMEM)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of duration of rapid weight loss on body composition change in elite collegiate wrestlers2017

    • Author(s)
      Kondo E, Yamada Y, Sagayama H, Shiose K, Onishi T, Motonaga K, Kamei A, Nakajima K, Ebine N, Higaki Y, Tanaka H, Okamura K, Takahashi H.
    • Organizer
      4th International Recent Advances and Controversies in Measurement of Energy Metabolism (RACMEM)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Body water assessment using bioimpedance spectroscopy during the rapid weight loss and recovery in Japanese wrestlers2016

    • Author(s)
      Shiose K, Kondo E, Sagayama H, Yamada Y, Osawa T, Motonaga K, Ohuchi S, Kamei A, Nakajima K, Higaki Y, Tanaka H, Takahashi H.
    • Organizer
      International Sports + Exercise Nutrition Conference
    • Place of Presentation
      Newcastle, UK.
    • Year and Date
      2016-12-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison of total energy expenditure vs age by doubly labeled water in healthy weight and obese United States adults2016

    • Author(s)
      Sagayama H, Yamada Y, Racine NM, Shriver TC, Schoeller DA
    • Organizer
      The Obesity Society
    • Place of Presentation
      New Orleans, LA, USA.
    • Year and Date
      2016-11-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Thoracic gas volume changes after weight loss and regain associated with body-fat measurement in wrestlers2016

    • Author(s)
      Kondo E, Shiose K, Motonaga K, Osawa T, Sagayama H, Yamada Y, Nakajima K, Kamei A, Takahashi H.
    • Organizer
      American College of Sports and Medicene
    • Place of Presentation
      Denver, Colorado, USA.
    • Year and Date
      2016-06-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Energy balance and fat and fat-free mass changes during rapid weight loss program2016

    • Author(s)
      Kondo E, Shiose K, Sagayama H, Yamada Y, Osawa T, Motonaga K, Ohuchi S, Kamei A, Nakajima K, Higaki Y, Tanaka H, Takahashi H
    • Organizer
      International Congress on Obesity
    • Place of Presentation
      Vancouver, Canada.
    • Year and Date
      2016-05-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Objective energy requirements and water intake in 2,297 humans aged 0.25 to 89 years measured by doubly labeled water2016

    • Author(s)
      Yamada Y, Sagayama H, Racine NM, Shriver TC, Schoeller DA, DLW Study Group
    • Organizer
      International Congress on Obesity
    • Place of Presentation
      Vancouver, Canada.
    • Year and Date
      2016-05-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dilution space ratio of deuterium and oxygen-18 of doubly labeled water method in humans2016

    • Author(s)
      Sagayama H, Yamada Y, Racine NM, Shriver TC, Schoeller DA, DLW Study Group.
    • Organizer
      International Congress on Obesity
    • Place of Presentation
      Vancouver, Canada.
    • Year and Date
      2016-05-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Book] 体育の科学2016

    • Author(s)
      下山 寛之, 田中 宏暁
    • Total Pages
      5
    • Publisher
      杏林書院
    • Related Report
      2016 Annual Research Report
  • [Remarks] 運動・食事指導に観光を組み合わせた7泊8日の「ヘルスツーリズム」で身体が劇的に変化

    • URL

      http://www.suisin.fukuoka-u.ac.jp/home1/branding/paper/20180522000630.html

    • Related Report
      2018 Annual Research Report

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Published: 2016-05-17   Modified: 2019-12-27  

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