Network analysis for prognostic factors of heart failure using longitudinal data from huge cohort data

• Project/Area Number: 16K00039
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Statistical science
• Research Institution: Tohoku University
• Principal Investigator: Miyata Satoshi 東北大学, 医学系研究科, 准教授 (60360343)
• Co-Investigator(Kenkyū-buntansha): 坂田 泰彦 東北大学, 医学系研究科, 准教授 (90379206)
• Research Collaborator: Miura Masanobu ; Yamauchi Takeshi ; Onose Takeshi ; Tsuji Kanako ; Oikawa Takuya ; Kasahara Shintaro
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: コホート研究 / ネットワーク解析 / 関数主成分分析 / 慢性心不全 / 生物統計学 / 構造方程式モデル / 構造方程式モデリング / 関数データ解析 / アンケート調査 / 統計数学

Outline of Final Research Achievements

In the present study, the cohort data of the chronic heart failure of 10,219 patients registered from 2006 to 2010 in Chronic Heart Failure Analysis and Registry in the Tohoku District 2 (CHART-2 study) was used.
We developed functional component analysis using longitudinal data as functional data for risk stratification, which was treated as supervised learning　model with survival data.
The implication of the results of the present study was clinically examined by the specialist of the cardiovascular internal medicine. It was confirmed that the patients were effectively classified according to the risk of the occurrence of the heart failure by the proposed methodology.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果，膨大なコホートデータに蓄積された経時データを関数主成分分析によって解析することにより、心不全患者の発症リスクを効果的に判別することに成功した。
研究の成果は，約30編の原著論文（査読あり）と多数の国際学会において報告した．

Research Products

• [Journal Article] Cardiac Lymphatic Dysfunction Causes Drug-Eluting Stent-Induced Coronary Hyperconstricting Responses in Pigs In Vivo (2019)
  • Author(s): Amamizu Hirokazu、Matsumoto Yasuharu、Morosawa Susumu、Ohyama Kazuma、Uzuka Hironori、Hirano Michinori、Nishimiya Kensuke、Gokon Yusuke、Watanabe-Asaka Tomomi、Hayashi Moyuru、Miyata Satoshi、Kamei Takashi、Kawai Yoshiko、Shimokawa Hiroaki
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology Volume: 39 Issue: 4 Pages: 741
  • DOI: 10.1161/atvbaha.119.312396
  • Peer Reviewed / Open Access
• [Journal Article] Conversion formula from B-type natriuretic peptide to N-terminal proBNP values in patients with cardiovascular diseases (2019)
  • Author(s): Kasahara S, Sakata Y, Nochioka K, Miura M, Abe R, Sato M, Aoyanagi H, Fujihashi T, Yamanaka S, Shiroto T, Sugimura K, Takahashi J, Miyata S, Shimokawa H.
  • Journal Title: International Journal of Cardiology Volume: 280 Pages: 184
  • DOI: 10.1016/j.ijcard.2018.12.069
  • Peer Reviewed / Open Access
• [Journal Article] Gender differences in prognostic relevance of self-care behaviors on mortality and hospitalization in patients with heart failure – A report from the CHART-2 Study (2019)
  • Author(s): Abe Ruri、Sakata Yasuhiko、Nochioka Kotaro、Miura Masanobu、Oikawa Takuya、Kasahara Shintaro、Sato Masayuki、Aoyanagi Hajime、Shiroto Takashi、Sugimura Koichiro、Takahashi Jun、Miyata Satoshi、Shimokawa Hiroaki
  • Journal Title: Journal of Cardiology Volume: 73 Issue: 5 Pages: 370
  • DOI: 10.1016/j.jjcc.2018.11.006
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic impact of residual stenosis after percutaneous coronary intervention in patients with ischemic heart failure – A report from the CHART-2 study (2019)
  • Author(s): Hao Kiyotaka、Takahashi Jun、Sakata Yasuhiko、Miyata Satoshi、Shiroto Takashi、Nochioka Kotaro、Miura Masanobu、Oikawa Takuya、Abe Ruri、Sato Masayuki、Kasahara Shintaro、Aoyanagi Hajime、Shimokawa Hiroaki
  • Journal Title: International Journal of Cardiology Volume: 278 Pages: 22
  • DOI: 10.1016/j.ijcard.2018.10.062
  • Peer Reviewed / Open Access
• [Journal Article] The 3A3B score: The simple risk score for heart failure with preserved ejection fraction - A report from the CHART-2 Study (2019)
  • Author(s): Kasahara Shintaro、Sakata Yasuhiko、Nochioka Kotaro、Tay Wan Ting、Claggett Brian Lee、Abe Ruri、Oikawa Takuya、Sato Masayuki、Aoyanagi Hajime、Miura Masanobu、Shiroto Takashi、Takahashi Jun、Sugimura Koichiro、Teng Tiew-Hwa Katherine、Miyata Satoshi、Shimokawa Hiroaki
  • Journal Title: International Journal of Cardiology Volume: 284 Pages: 42
  • DOI: 10.1016/j.ijcard.2018.10.076
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Whole-brain low-intensity pulsed ultrasound therapy markedly improves cognitive dysfunctions in mouse models of dementia - Crucial roles of endothelial nitric oxide synthase (2018)
  • Author(s): Eguchi Kumiko、Shindo Tomohiko、Ito Kenta、Ogata Tsuyoshi、Kurosawa Ryo、Kagaya Yuta、Monma Yuto、Ichijo Sadamitsu、Kasukabe Sachie、Miyata Satoshi、Yoshikawa Takeo、Yanai Kazuhiko、Taki Hirofumi、Kanai Hiroshi、Osumi Noriko、Shimokawa Hiroaki
  • Journal Title: Brain Stimulation Volume: 11 Issue: 5 Pages: 959
  • DOI: 10.1016/j.brs.2018.05.012
  • Peer Reviewed / Open Access
• [Journal Article] Low-energy cardiac shockwave therapy to suppress left ventricular remodeling in patients with acute myocardial infarction: A first-in-human study (2018)
  • Author(s): Kagaya Yuta、Ito Kenta、Takahashi Jun、Matsumoto Yasuharu、Shiroto Takashi、Tsuburaya Ryuji、Kikuchi Yoku、Hao Kiyotaka、Nishimiya Kensuke、Shindo Tomohiko、Ogata Tsuyoshi、Kurosawa Ryo、Eguchi Kumiko、Monma Yuto、Ichijo Sadamitsu、Hatanaka Kazuaki、Miyata Satoshi、Shimokawa Hiroaki
  • Journal Title: Coronary Artery Disease Volume: 29 Issue: 4 Pages: 294
  • DOI: 10.1097/mca.0000000000000577
  • Peer Reviewed / Open Access
• [Journal Article] Comparable prognostic impact of BNP levels among HFpEF, Borderline HFpEF and HFrEF: a report from the CHART-2 Study (2018)
  • Author(s): Kasahara S, Sakata Y, Nochioka K, Yamauchi T, Onose T, Tsuji K, Abe R, Oikawa T, Sato M, Aoyanagi H, Miura M, Shiroto T, Takahashi J, Miyata S, Shimokawa H; CHART-2 Investigators.
  • Journal Title: Heart Vessels Volume: 33 Issue: 9 Pages: 997
  • DOI: 10.1007/s00380-018-1150-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Selenoprotein P promotes the development of pulmonary arterial hypertension: Possible novel therapeutic target (2018)
  • Author(s): Kikuchi N, Satoh K, Kurosawa R, Yaoita N, Elias-Al-Mamun M, Siddique MAH, Omura J, Satoh T, Nogi M, Sunamura S, Miyata S, Saito Y, Hoshikawa Y, Okada Y, Shimokawa H.
  • Journal Title: Circulation Volume: 138 Issue: 6 Pages: 600
  • DOI: 10.1161/circulationaha.117.033113
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Significance of PR Interval Prolongation in Adult Patients With Total Correction of Tetralogy of Fallot (2018)
  • Author(s): Kimura Yoshitaka、Fukuda Koji、Nakano Makoto、Hasebe Yuhi、Fukasawa Kyoshiro、Chiba Takahiko、Miki Keita、Tatebe Shunsuke、Miyata Satoshi、Ota Hideki、Kimura Masato、Adachi Osamu、Saiki Yoshikatsu、Shimokawa Hiroaki
  • Journal Title: Circulation: Arrhythmia and Electrophysiology Volume: 11 Issue: 11 Pages: 1-11
  • DOI: 10.1161/circep.118.006234
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Hepatitis C Virus Antibody-Positivity on Cardiac Function and Long-Term Prognosis in Patients With Adult Congenital Heart Disease (2018)
  • Author(s): Konno Ryo、Tatebe Shunsuke、Sugimura Koichiro、Satoh Kimio、Aoki Tatsuo、Miura Masanobu、Yamamoto Saori、Sato Haruka、Kozu Katsuya、Terui Yosuke、Miyata Satoshi、Adachi Osamu、Kimura Masato、Saiki Yoshikatsu、Shimokawa Hiroaki
  • Journal Title: The American Journal of Cardiology Volume: 122 Issue: 11 Pages: 1965
  • DOI: 10.1016/j.amjcard.2018.08.045
  • Peer Reviewed / Open Access
• [Journal Article] Sex differences in hemodynamic responses and long-term survival to optimal medical therapy in patients with pulmonary arterial hypertension (2018)
  • Author(s): Kozu K, Sugimura K, Aoki T, Tatebe S, Yamamoto S, Yaoita N, Shimizu T, Nochioka K, Sato H, Konno R, Satoh K, Miyata S, Shimokawa H.
  • Journal Title: Heart Vessels. Volume: 33 Issue: 8 Pages: 939
  • DOI: 10.1007/s00380-018-1140-6
  • Peer Reviewed / Open Access
• [Journal Article] Small GTP-Binding Protein GDP Dissociation Stimulator Prevents Thoracic Aortic Aneurysm Formation and Rupture by Phenotypic Preservation of Aortic Smooth Muscle Cells (2018)
  • Author(s): Nogi Masamichi、Satoh Kimio、Sunamura Shinichiro、Kikuchi Nobuhiro、Satoh Taijyu、Kurosawa Ryo、Omura Junichi、Elias-Al-Mamun Md.、Abdul Hai Siddique Mohammad、Numano Kazuhiko、Kudo Shun、Miyata Satoshi、Akiyama Masatoshi、Kumagai Kiichiro、Kawamoto Shunsuke、Saiki Yoshikatsu、Shimokawa Hiroaki
  • Journal Title: Circulation Volume: 138 Issue: 21 Pages: 2413
  • DOI: 10.1161/circulationaha.118.035648
  • Peer Reviewed / Open Access
• [Journal Article] Sex Differences in Patients With Chronic Heart Failure With Reference to Left Ventricular Ejection Fraction (2018)
  • Author(s): Sakata Yasuhiko、Miyata Satoshi、Nochioka Kotaro、Miura Masanobu、Shiroto Takashi、Shimokawa Hiroaki
  • Journal Title: Gender and the Genome Volume: 2 Issue: 1 Pages: 27-42
  • DOI: 10.1177/2470289718787115
  • Peer Reviewed / Open Access
• [Journal Article] Different roles of myocardial ROCK1 and ROCK2 in cardiac dysfunction and postcapillary pulmonary hypertension in mice (2018)
  • Author(s): Sunamura Shinichiro、Satoh Kimio、Kurosawa Ryo、Ohtsuki Tomohiro、Kikuchi Nobuhiro、Elias-Al-Mamun Md.、Shimizu Toru、Ikeda Shohei、Suzuki Kota、Satoh Taijyu、Omura Junichi、Nogi Masamichi、Numano Kazuhiko、Siddique Mohammad Abdul Hai、Miyata Satoshi、Miura Masahito、Shimokawa Hiroaki
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 115 Issue: 30
  • DOI: 10.1073/pnas.1721298115
  • Peer Reviewed / Open Access
• [Journal Article] Structural brain abnormalities and cardiac dysfunction in patients with chronic heart failure (2018)
  • Author(s): Hideaki Suzuki, Yasuharu Matsumoto, Hideki Ota, Koichiro Sugimura, Jun Takahashi, Kenta Ito, Satoshi Miyata, Yoshihiro Fukumoto, Yasuyuki Taki, Hiroaki Shimokawa.
  • Journal Title: European Journal of Heart Failure Volume: 20 Issue: 5 Pages: 936
  • DOI: 10.1002/ejhf.1104
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic impact of statin intensity in heart failure patients with ischemic heart disease: A report from the CHART-2 (Chronic Heart Failure Registry and Analysis in the Tohoku District 2) study (2018)
  • Author(s): Oikawa T, Sakata Y, Nochioka K, Miura M, Tsuji K, Onose T, Abe R, Kasahara S, Sato M, Shiroto T, Takahashi J, Miyata S, Shimokawa H; CHART‐2 invesigators.
  • Journal Title: J Am Heart Assoc. Volume: 7 Issue: 6 Pages: 1-21
  • DOI: 10.1161/jaha.117.007524
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sex differences in post-traumatic stress disorder in cardiovascular patients after the Great East Japan Earthquake: A report from the CHART-2 Study (2017)
  • Author(s): Onose T, Sakata Y, Nochioka K, Miura M, Yamauchi T, Tsuji K, Abe R, Oikawa T, Kasahara S, Sato M, Shiroto T, Miyata S, Takahashi J, Shimokawa H; CHART-2 Investigators.
  • Journal Title: Eur Heart J Qual Care Clin Outcomes Volume: 3 Issue: 3 Pages: 224
  • DOI: 10.1093/ehjqcco/qcx009
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characterization of heart failure patients with mid-range left ventricular ejection fraction—a report from the CHART-2 Study (2017)
  • Author(s): Tsuji K, Sakata Y, Nochioka K, Miura M, Yamauchi T, Onose T, Abe R, Oikawa T, Kasahara S, Sato M, Shiroto T, Takahashi J, Miyata S, Shimokawa H; CHART-2 Investigators.
  • Journal Title: Eur J Heart Fail Volume: 19 Issue: 10 Pages: 1258
  • DOI: 10.1002/ejhf.807
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long-term prognostic impact of the Great East Japan Earthquake in patients with cardiovascular disease – Report from the CHART-2 Study (2017)
  • Author(s): Miyata S, Sakata Y, Miura M, Yamauchi T, Onose T, Tsuji K, Abe R, Oikawa T, Kasahara S, Sato M, Nochioka K, Shiroto T, Takahashi J, Shimokawa H; CHART-2 Investigators.
  • Journal Title: J Cardiol. Volume: 70 Issue: 3 Pages: 286
  • DOI: 10.1016/j.jjcc.2016.10.018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic Impact of Atrial Fibrillation and New Risk Score of Its Onset in Patients at High Risk of Heart Failure ― A Report From the CHART-2 Study ― (2017)
  • Author(s): Yamauchi T, Sakata Y, Miura M, Onose T, Tsuji K, Abe R, Oikawa T, Kasahara S, Sato M, Nochioka K, Shiroto T, Takahashi J, Miyata S, Shimokawa H; CHART-2 Investigators
  • Journal Title: Circulation Journal Volume: 81 Issue: 2 Pages: 185-194
  • DOI: 10.1253/circj.CJ-16-0759
  • NAID: 130005298633
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Influence of Left Ventricular Ejection Fraction on the Effects of Supplemental Use of Angiotensin Receptor Blocker Olmesartan in Hypertensive Patients With Heart Failure (2016)
  • Author(s): Miura M, Sakata Y, Miyata S, Shiba N, Takahashi J, Nochioka K, Takada T, Saga C, Shinozaki T, Sugi M, Nakagawa M, Sekiguchi N, Komaru T, Kato A, Fukuchi M, Nozaki E, Hiramoto T, Inoue K, Goto T, Ohe M, Tamaki K, Ibayashi S, Ishide N, Maruyama Y, Tsuji I, Shimokawa H; SUPPORT Trial Investigators
  • Journal Title: Circulation Journal Volume: 80 Issue: 10 Pages: 2155-2164
  • DOI: 10.1253/circj.CJ-16-0577
  • NAID: 130005419074
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic Impact of Loop Diuretics in Patients With Chronic Heart Failure – Effects of Addition of Renin-Angiotensin-Aldosterone System Inhibitors and β-Blockers – (2016)
  • Author(s): Miura M, Sugimura K, Sakata Y, Miyata S, Tadaki S, Yamauchi T, Onose T, Tsuji K, Abe R, Oikawa T, Kasahara S, Nochioka K, Takahashi J, Shimokawa H; CHART-2 Investigators
  • Journal Title: Circulation Journal Volume: 80 Issue: 6 Pages: 1396-1403
  • DOI: 10.1253/circj.CJ-16-0216
  • NAID: 130005153602
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Prognostic impact of diabetes mellitus in patients with chronic heart failure -With special references to ischemic heart disease and nephropathy- (2018)
  • Author(s): Miura M, Sakata Y, Sato M, Abe R, Kasahara S, Aoyanagi H, Fujihashi T, Yamanaka S, Shiroto T, Nochioka K, Sugimura K, Takahashi J, Miyata S, Shimokawa H
  • Organizer: Heart Failure Seoul 2018 (Seoul, Korea)
  • Int'l Joint Research
• [Presentation] SmgGDS prevents thoracic aortic aneurysm formation and rupture by phenotypic preservation of aortic smooth muscle cells (2018)
  • Author(s): Nogi M, Satoh K, Kudo S, Sunamura S, Kikuchi N, Satoh T, Kurosawa R, Omura J, Al-Mamun E, Siddique MA, Numano K, Miyata S, Akiyama M, Kumagai S, Saiki Y, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • Int'l Joint Research
• [Presentation] Prognostic impacts of soluble basigin in patients with chronic heart failure -the novel aspect of the multifunctional inflammatory protein (2018)
  • Author(s): Satoh K, Miyata S, Ohtsuki T, Nochioka K, Miura M, Shiroto T, Sunamura S, Nogi M, Kurosawa R, Kikuchi N, Satoh T, Sakata Y, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • Int'l Joint Research
• [Presentation] Clinical characteristics, prognosis and prognostic factors of elderly patients with chronic heart failure: A report from the CHART-2 Study (2018)
  • Author(s): Sato M, Sakata Y, Nochioka K, Miura M, Kasahara S, Aoyanagi H, Fujihashi T, Yamanaka S, Abe R, Oikawa T, Shiroto T, Sugimura K, Takahashi J, Miyata S, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • Int'l Joint Research
• [Presentation] Benefit and risk of antithrombotic therapy in patients with atrial fibrillation -A report from the CHART-2 Study- (2018)
  • Author(s): Shiroto T, Sakata Y, Nochioka K, Abe R, Oikawa T, Kasahara S, Sato M, Aoyanagi H, Yamanaka S, Fujihashi T, Miura M, Takahashi J, Miyata S, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • Int'l Joint Research
• [Presentation] Elevated serum triglyceride level as a significant residual risk for acute myocardial infraction in patients with stable ischemic heart disease under statin treatment -A report from the CHART-2 Study- (2018)
  • Author(s): Suzuki K, Oikawa T, Nochioka K, Miura M, Abe R, Kasahara S, Sato M, Aoyanagi H, Shiroto T, Takahashi J, Miyata S, Sakata Y, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • Int'l Joint Research
• [Presentation] Prognostic impacts of serum levels of selenoprotein P in patients with pulmonary arterial hypertension (2018)
  • Author(s): Kikuchi N, Satoh K, Tanaka M, Kato S, Omura J, Satoh T, Kurosawa R, Nogi M, Sunamura S, Yaoita N, Miyata S, Misu H, Saito Y, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • Int'l Joint Research
• [Presentation] Simple risk model for heart failure with preserved ejection fraction -A report from the CHART-2 Study (2018)
  • Author(s): Kasahara S, Sakata Y, Nochioka K, Abe R, Sato M, Aoyanagi H, Fujihashi T, Yamanaka S, Miura M, Shiroto T, Takahashi J, Sugimura K, Miyata S, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • Int'l Joint Research
• [Presentation] Prognostic impacts of impaired coronary vasodilator function and enhanced vasoconstriction responses in patients with angina and unobstructive coronary arteries (2018)
  • Author(s): Suda A, Takahashi J, Hao K, Kikuchi Y, Shindo T, Ikeda S, Sato K, Sugisawa J, Matsumoto Y, Miyata S, Sakata Y, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • Int'l Joint Research
• [Presentation] Prognostic impact of temporal changes in left ventricular ejection fraction in patients with stage B heart failure (2018)
  • Author(s): Aoyanagi H, Sakata Y, Nochioka K, Miura M, Shiroto T, Abe R, Kasahara S, Sato M, Fujihashi T, Yamanaka S, Sugimura K, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • Int'l Joint Research
• [Presentation] Development of useful conversion equation between B-type natriuretic peptide and N-terminal pro BNP levels. (2018)
  • Author(s): Kasahara S, Sakata Y, Nochioka K, Abe R, Sato M, Aoyanagi H, Miura M, Shiroto T, Takahashi J, Sugimura K, Miyata S, Shimokawa H.
  • Organizer: 22nd Annual Scientific Meeting of Heart Failure Society of America (HFSA) (Nashville, USA)
  • Int'l Joint Research
• [Presentation] Prognostic impacts of soluble form of basigin in patients with chronic heart failure -from a prospective large clinical trial with 1,147 patients- (2018)
  • Author(s): Satoh K, Miyata S, Miura M, Ohtsuki T, Nochioka K, Sunamura S, Nogi M, Kurosawa R, Kikuchi N, Satoh T, Aoki T, Tatebe S, Sugimura K, Sakata Y, Shimokawa H.
  • Organizer: ESC Congress 2018 (Munich, Germany)
  • Int'l Joint Research
• [Presentation] Prognostic impacts of impaired coronary vasodilatation and enhanced coronary vasoconstricting responses in patients with angina and unobstructive coronary arteries. (2018)
  • Author(s): Suda A, Takahashi J, Hao K, Kikuchi Y, Shindo T, Sato K, Sugisawa J, Matsumoto Y, Miyata S, Sakata Y, Shimokawa H.
  • Organizer: ESC Congress 2018 (Munich, Germany)
  • Int'l Joint Research
• [Presentation] Clinical impacts of wide ORS morphologies on deterioration of left ventricular ejection fraction and fatal arrhythmias in patients with relatively preserved left ventricular ejection function. (2018)
  • Author(s): Kimura Y, Nakano M, Sakata Y, Nochioka K, Hasebe Y, Abe R, Chiba T, Fukasawa K, Oikawa T, Kasahara S, Miki K, Sato M, Shiroto T, Miyata S, Shimokawa H.
  • Organizer: ESC Congress 2018 (Munich, Germany)
  • Int'l Joint Research
• [Presentation] Impact of temporal changes in left ventricular ejection fraction in patients at risk for heart failure. (2018)
  • Author(s): Aoyanagi H, Sakata Y, Nochioka K, Shiroto T, Oikawa T, Abe R, Kasahara S, Sato M, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: ESC Congress 2018 (Munich, Germany)
  • Int'l Joint Research
• [Presentation] Increased risk of cancer death in patients with chronic heart failure with a special reference to inflammation and diabetes mellitus -A report from the CHART-2 Study (2018)
  • Author(s): Sakata Y, Oikawa T, Nochioka K, Miura M, Abe R, Kasahara S, Sato M, Aoyanagi H, Shiroto T, Sugimura K, Takahashi J, Miyata S, Shimokawa H
  • Organizer: Heart Failure 2018 (Vienna, Austria)
  • Int'l Joint Research
• [Presentation] Sex differences in temporal changes in left ventricular ejection fraction among patients with heart failure -A report from the CHART-2 Study- (2018)
  • Author(s): Tsuji K, Sakata Y, Nochioka K, Miura M, Abe R, Oikawa T, Kasahara S, Sato M, Aoyanagi H, Shiroto T, Takahashi J, Miyata S, Shimokawa H
  • Organizer: Heart Failure 2018 (Vienna, Austria)
  • Int'l Joint Research
• [Presentation] Association between impaired glucose tolerance and prognosis according to presence of microalbuminuria in patients with chronic heart failure (2018)
  • Author(s): Nochioka K, Sakata Y, Abe R, Oikawa T, Kasahara S, Sato M, Aoyanagi H, Miura M, Shiroto T, Takahashi J, Miyata S, Shimokawa H
  • Organizer: Heart Failure 2018 (Vienna, Austria)
  • Int'l Joint Research
• [Presentation] Derivation and validation of a conversion equation between B-type natriuretic peptide and N-terminal pro BNP levels (2018)
  • Author(s): Kasahara S, Sakata Y, Nochioka K, Abe R, Oikawa T, Sato M, Aoyanagi H, Miura M, Shiroto T, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: Heart Failure 2018 (Vienna, Austria)
  • Int'l Joint Research
• [Presentation] Antithrombotic therapy improves long-term prognosis in patients with atrial fibrillation and heart failure -A report from the CHART-2 Study (2018)
  • Author(s): Shiroto T, Sakata Y, Nochioka K, Abe R, Oikawa T, Kasahara S, Sato M, Aoyanagi H, Miura M, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: Heart Failure 2018 (Vienna, Austria)
  • Int'l Joint Research
• [Presentation] Evidence for Sex Differences in Japanese Patients with Chronic Heart Failure -A Report from the CHART-2 Study- (2018)
  • Author(s): Sakata Y, Nochioka K, Abe R, Oikawa T, Kasahara S, Sato M, Aoyanagi H, Miura M, Shiroto T, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: The 82nd Annual Scientific Meeting of the Japanese Circulation Society
  • Int'l Joint Research / Invited
• [Presentation] Transition of Left Ventricular Ejection Fraction in Heart Failure: Is HFmrEF Closer to HFpEF than to HFrEF? (2018)
  • Author(s): Sakata Y, Nochioka K, Miyata S, Shimokawa H.
  • Organizer: The 82nd Annual Scientific Meeting of the Japanese Circulation Society
  • Int'l Joint Research / Invited
• [Presentation] Prognostic Impact of Impaired Glucose Tolerance in Relation with Microalbuminuria in Patients with Chronic Heart Failure: The SUPPORT Trial Subanalysis (2018)
  • Author(s): Nochioka K, Sakata Y, Shiroto T, Oikawa T, Abe R, Kasahara S, Sato M, Aoyanagi H, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: The 82nd Annual Scientific Meeting of the Japanese Circulation Society
  • Int'l Joint Research / Invited
• [Presentation] Development of a Conversion Formula between B-type Natriuretic Peptide and N-terminal Pro BNP Levels (2018)
  • Author(s): Kasahara S, Sataka Y, Nochioka K, Abe R, Oikawa T, Sato M, Aoyanagi H, Miura M, Shiroto T, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: The 82nd Annual Scientific Meeting of the Japanese Circulation Society
  • Int'l Joint Research / Invited
• [Presentation] Impact of Transition of Left Ventricular Ejection Fraction in Patients at Risk for Heart Failure: Report from the CHART-2 Study (2018)
  • Author(s): Aoyanagi H, Sakata Y, Nochioka K, Shiroto T, Oikawa T, Abe R, Kasahara S, Sato M, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: The 82nd Annual Scientific Meeting of the Japanese Circulation Society
  • Int'l Joint Research / Invited
• [Presentation] Differences in Health Consciousness and Prognosis of Patients with Chronic Heart Failure -A Report from the CHART-2 Study- (2018)
  • Author(s): Abe R, Sakata Y, Nochioka K, Oikawa T, Kasahara S, Sato M, Aoyanagi H, Miura M, Shiroto T, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: The 82nd Annual Scientific Meeting of the Japanese Circulation Society
  • Int'l Joint Research / Invited
• [Presentation] Clinical Characteristics and Prognostic Factors in Elderly Patients with Chronic Heart Failure -A Report from the CHART-2 Study- (2018)
  • Author(s): Sato M, Sakata Y, Oikawa T, Abe R, Kasahara S, Aoyanagi H, Miura M, Nochioka K, Shiroto T, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: The 82nd Annual Scientific Meeting of the Japanese Circulation Society
  • Int'l Joint Research / Invited
• [Presentation] Prognostic Impact of Triglycerides Levels in the Secondary Prevention of Patients with Myocardial Infarction -A Report from the CHART-2 Study- (2018)
  • Author(s): Oikawa T, Sakata Y, Nochioka K, Miura M, Abe R, Kasahara S, Sato M, Aoyanagi H, Shiroto T, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: The 82nd Annual Scientific Meeting of the Japanese Circulation Society
  • Int'l Joint Research / Invited
• [Presentation] Prognostic Impact of and Risk Score for the Onset of Atrial Fibrillation in Patients at High Risk for Heart Failure -A Report From the CHART-2 Study- (2016)
  • Author(s): Yamauchi T, Sakata Y, Miura M, Onose T, Tsuji K, Abe R, Oikawa T, Kasahara S, Nochioka N, Takahashi J, Shiroto T, Miyata S, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: New Orleans , USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Unique Clinical Features of Patients With Heart Failure With Preserved Ejection Fraction -Insights From the CHART-2 Study- (2016)
  • Author(s): Tsuji K, Sakata Y, Miura M, Yamauchi T, Onose T, Abe R, Oikawa T, Kasahara S, Sato M, Shiroto T, Nochioka K, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: New Orleans , USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Comparable Prognostic Impacts of B-type Natriuretic Peptide Levels bBetween Heart Failure With Reduced and Preserved Ejection Fraction -a Report From the CHART-2 Study- (2016)
  • Author(s): Kasahara S, Sakata Y, Yamauchi T, Onose T, Tsuji K, Abe R, Oikawa T, Sato M, Nochioka K, Shiroto T, Takahashi J, Miyata S, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: New Orleans , USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Differences in clinical characteristics and prognosis between heart failure with preserved ejection fraction and that with reduced ejection fraction -Insights from the CHART-2 Study- (2016)
  • Author(s): Tsuji K, Sakata Y, Miura M, Miyata S, Nochioka K, Tadaki S, Yamauchi T, Onose T, Abe R, Oikawa T, Kasahara S, Takahashi J, Shimokawa H.
  • Organizer: The 20th Annual Scientific Meeting of the Heart Failure Society of America
  • Place of Presentation: Orlando, FL, USA
  • Year and Date: 2016-09-17
  • Int'l Joint Research
• [Presentation] Factors influencing daily exercise in patients with chronic heart failure A report from the multicenter prospective cohort study in Japan (2016)
  • Author(s): Tadaki S, Sakata Y, Miura Y, Fukumoto Y, Yano M, Kadokami T, Yasuda S, Daida H, Shimokawa H.
  • Organizer: The 20th Annual Scientific Meeting of the Heart Failure Society of America
  • Place of Presentation: Orlando, FL, USA
  • Year and Date: 2016-09-17
  • Int'l Joint Research
• [Presentation] Prognostic risk stratification with plasma B-type natriuretic peptide levels in patients with chronic heart failure - a report from the CHART-2 Study (2016)
  • Author(s): Kasahara S, Sakata Y, Miura M, Tadaki S, Tsuji K, Yamauchi T, Abe R, Oikawa T, Takahashi J, Miyata S, Shimokawa H
  • Organizer: ESC Congress 2016
  • Place of Presentation: Roma, Italy
  • Year and Date: 2016-08-27
  • Int'l Joint Research
• [Presentation] Evidence for a distinct entity of heart failure with preserved ejection frcation -A report from the CHART-2 Study- (2016)
  • Author(s): Tsuji K, Sakata Y, Miura M, Miyata S, Nochioka K, Tadaki S, Yamauchi T, Onose T, Abe R, Oikawa T, Kasahara S, Takahashi J, Shimokawa H.
  • Organizer: The 8th Asian Pacific Congress of Heart Failure
  • Place of Presentation: Gyengju, Korea
  • Year and Date: 2016-04-15
  • Int'l Joint Research
• [Presentation] Plasma B-type natriuretic peptide levels predict long-term prognosis of patients with chronic herat failure -A report from the CHART-2 Study- (2016)
  • Author(s): Kasahara S, Sakata Y, Miura M, Tadaki S, Onose T, Tsuji K, Yamauti T, Abe R, Oikawa T, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: The 8th Asian Pacific Congress of Heart Failure
  • Place of Presentation: Gyengju, Korea
  • Year and Date: 2016-04-15
  • Int'l Joint Research