• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Evlutionary compuation method to determine essential brain function regions and metabolites

Research Project

Project/Area Number 16K00312
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Intelligent informatics
Research InstitutionDoshisha University

Principal Investigator

Hiroyasu Tomoyuki  同志社大学, 生命医科学部, 教授 (20298144)

Co-Investigator(Kenkyū-buntansha) 渡邉 真也  室蘭工業大学, 大学院工学研究科, 准教授 (30388136)
杉本 昌弘  慶應義塾大学, 政策・メディア研究科(藤沢), 特任教授 (30458963)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords脳機能イメージング / fMRI / fNIRS / ヒトの状態推定 / 進化計算 / メタボローム / 脳機能 / スパースモデリング / コミュニケーション / マインドフルネス / 脳機能ネットワーク解析 / 協調作業 / 進化的計算
Outline of Final Research Achievements

There are two primary goals of this study, and they are to be accomplished in the following phases. The goal of the first phase is to identify the region of brain functions which determines the cluster of the subject's characteristics, and this goal is to be achieved using the brain functional data obtained by non-invasive human brain functional imaging systems, such as fMRI and fNIRS. The next goal is to identify metabolites highly relevant to cluster identification by measuring metabolic changes through analyses of Salivary metabolism. As we carried out the first phase, we made a dynamic network analysis to estimate individual state and developed a multi-objective genetic algorithm-based evolutionary method to identify functional brain regions to be focused on. In the second phase, we performed metabolome analysis and examination of saliva, but could not reach a point having enough evidence to propose a method of identifying the target substance.

Academic Significance and Societal Importance of the Research Achievements

深い知識を有しない場合や既存の研究例が存在しない場合、非侵襲な脳機能イメージング装置で脳機能データが取得できたとしても、注目すべき脳部位はどこであるかを決定することは難しい。今後、ますます種々のタスクに対して、様々な環境で脳機能情報が取得されることが予想されるが、データドリブンな方式で注目すべき脳部位が決定できることは大いに意義がある。また、fMRIやfNIRSなどの装置は大規模であるため実際の利用においては汎用性が低い。唾液などのメタボローム情報から脳機能状態が決定できれば、汎用性が高まり活用の範囲が拡がる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (33 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (3 results) Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (24 results) (of which Int'l Joint Research: 22 results)

  • [Int'l Joint Research] Otto von Guericke University Magdeburg(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Otto von Guericke University Magdeburg(Germany)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Otto von Guericke University Magdeburg(Germany)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Automated Extraction of Human Functional Brain Network Properties Associated with Working Memory Load through a Machine Learning-Based Feature Selection Algorithm2018

    • Author(s)
      Hiwa Satoru、Obuchi Shogo、Hiroyasu Tomoyuki
    • Journal Title

      Computational Intelligence and Neuroscience

      Volume: 2018 Pages: 1-12

    • DOI

      10.1155/2018/4835676

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional near-infrared spectroscopy study of the neural correlates between auditory environments and intellectual work performance2018

    • Author(s)
      Hiwa Satoru、Katayama Tomoka、Hiroyasu Tomoyuki
    • Journal Title

      Brain and Behavior

      Volume: 8 Issue: 10

    • DOI

      10.1002/brb3.1104

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Important Brain Function Networks Extraction using Adaptive Weight Vector Assignment Method for MOEA/D2018

    • Author(s)
      原田 圭、廣安 知之、日和 悟
    • Journal Title

      Transaction of the Japanese Society for Evolutionary Computation

      Volume: 9 Issue: 2 Pages: 75-85

    • DOI

      10.11394/tjpnsec.9.75

    • NAID

      130007496944

    • ISSN
      2185-7385
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluating working memory capacity with functional near-infrared spectroscopy measurement of brain activity2018

    • Author(s)
      Utako Yamamoto, Nozomi Mashima, Tomoyuki Hiroyasu
    • Journal Title

      Journal of Cognitive Enhancement

      Volume: 印刷中 Issue: 3 Pages: 217-224

    • DOI

      10.1007/s41465-017-0063-y

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Validity of decision mode analysis on an ROI determination problem in multichannel fNIRS data2017

    • Author(s)
      Satoru HIWA, Mitsunori MIKI and Tomoyuki HIROYASU
    • Journal Title

      Springer Artificial Life and Robotics

      Volume: 22-3 Issue: 3 Pages: 336-345

    • DOI

      10.1007/s10015-017-0362-5

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analyzing Brain Functions by Subject Classification of Functional Near-Infrared Spectroscopy Data Using Convolutional Neural Networks Analysis2016

    • Author(s)
      Satoru HIWA, Kenya HANAWA, Ryota TAMURA, Keisuke HACHISUKA and Tomoyuki HIROYASU
    • Journal Title

      Hindawi Publishing Corporation Computational Intelligence and Neuroscience

      Volume: 2016 Pages: 1-9

    • DOI

      10.1155/2016/1841945

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Construction of a meditation practice support system leads to a good meditation state: an fNIRS study2019

    • Author(s)
      Seika FUJII, Satoru HIWA, Hiroshi FURUTANI and Tomoyuki HIROYASU
    • Organizer
      International Symposium on Artificial Life and Robotics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mapping the brain state behavior during meditation in low dimensional feature space2018

    • Author(s)
      Takuma MIYOSHI, Satoru HIWA and Tomoyuki HIROYASU
    • Organizer
      Organization for Human Brain Mapping (OHBM)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Solution Exploration using Multi-Objective Genetic Algorithm for Determining Experiment Candidate2018

    • Author(s)
      Lorenzo Perino, Akihiro FUJII, Tsuyoshi WAKU, Akira KOBAYASHI, Satoru HIWA and Tomoyuki HIROYASU
    • Organizer
      Genetic and Evolutionary Computation Conference (GECCO 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A fNIRS study of attentional state induced by breath-counting meditation2018

    • Author(s)
      Shoko YAMAMOTO, Satoru HIWA and Tomoyuki HIROYASU
    • Organizer
      Society for fNIRS
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional connectivity analysis during breath-counting meditation using multichannel fNIRS2017

    • Author(s)
      Tomoka KATAYAMA
    • Organizer
      Organization for Human Brain Mapping (OHBM)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Adaptive Weight Vector Assignment Method for MOEA/D2017

    • Author(s)
      Kei HARADA
    • Organizer
      The Institute of Electrical and Electronics Engineers(IEEE)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sparse Feature Selection Method by Pareto-front Exploration -Extraction of functional brain network and ROI for fMRI data2017

    • Author(s)
      Yuuki KOHRI
    • Organizer
      The Institute of Electrical and Electronics Engineers(IEEE)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Brain region segmentation method using SLIC and Normalized Cut2017

    • Author(s)
      Keisuke NAKAMURA
    • Organizer
      Organization for Human Brain Mapping (OHBM)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Frontal lobe activity during breath-counting meditation: fNIRS study2017

    • Author(s)
      Seika FUJII
    • Organizer
      Organization for Human Brain Mapping (OHBM)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Characterizing the meditative state based on functional connectivity and low-frequency fluctuation2017

    • Author(s)
      Satoru HIWA
    • Organizer
      Organization for Human Brain Mapping (OHBM)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Intra-individual variations in functional connectivity during resting and meditative states2017

    • Author(s)
      Takeru AIMOTO
    • Organizer
      Organization for Human Brain Mapping (OHBM)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of breath-counting meditation on functional brain connectivity and salivary hormones2017

    • Author(s)
      Takuma MIYOSHI
    • Organizer
      Organization for Human Brain Mapping (OHBM)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of a GLM analysis with adaptive hemodynamic response function on a visual stimulus task2017

    • Author(s)
      Saki IKEDA
    • Organizer
      Organization for Human Brain Mapping (OHBM)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Classification of brain states using functional data obtained during a mental arithmetic task2017

    • Author(s)
      Rina HAGIWARA
    • Organizer
      Organization for Human Brain Mapping (OHBM)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Adaptive HRF analysis of fNIRS data2017

    • Author(s)
      Saki YOSHITAKE
    • Organizer
      Organization for Human Brain Mapping (OHBM)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Detecting meditative states through meta-state matching with time-varying functional connectivity matrices2017

    • Author(s)
      Satoru HIWA
    • Organizer
      Society for Neuroscience(SFN)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Network analysis of brain activity during breath-counting meditation by fNIRS, Society for Neuroscience Proceedings2017

    • Author(s)
      Shoko YAMAMOTO
    • Organizer
      Society for Neuroscience(SFN)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Brain activity and functional connectivity in attention and careless states by fNIRS2017

    • Author(s)
      Miyu NISHIZAWA
    • Organizer
      Society for Neuroscience(SFN)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clusterwise low-rank correlation analysis based on majorization2017

    • Author(s)
      Kensuke TANIOKA
    • Organizer
      IASC-ARS/NZSA
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] fNIRS のチャンネル選択問題におけるNSGA-II とMOEA/Dの探索性能比較2016

    • Author(s)
      原田 圭, 日和 悟, 廣安 知之
    • Organizer
      進化計算学会、シンポジウム
    • Place of Presentation
      一宮シーサイドオーツカ (千葉県九十九里)
    • Year and Date
      2016-12-10
    • Related Report
      2016 Research-status Report
  • [Presentation] Region of interest Extraction of fMRI data using Genetic Algorithms2016

    • Author(s)
      Satoru HIWA, Yuuki KOHRI, Keisuke HACHISUKA and Tomoyuki HIROYASU
    • Organizer
      IEEE Proceedings of 2016 Symposium Series on Computational Intelligenc
    • Place of Presentation
      the Royal Olympic Hotel (Athens, Greece)
    • Year and Date
      2016-12-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] キックアウト手法を用いた遺伝的アルゴリズムによる脳機能ネットワーク抽出2016

    • Author(s)
      原田 圭, 日和 悟, Heiner ZILLE, Sanaz MOSTAGHIM, 廣安 知之
    • Organizer
      計測自動制御学会 システム・情報部門学術講演会(SSI2016)
    • Place of Presentation
      ウカルちゃんアリーナ(滋賀県立体育館)(滋賀県大津市)
    • Year and Date
      2016-12-06
    • Related Report
      2016 Research-status Report
  • [Presentation] An fNIRS study of cooperativeness during synchronized tapping task2016

    • Author(s)
      Akiho MURAKAMI, Hisatake YOKOUCHI, Satoru HIWA and Tomoyuki HIROYASU
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      the San Diego Convention Center (San Diego, USA)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Functional brain network extraction using a genetic algorithm with a kick-out method2016

    • Author(s)
      Kei HARADA, Misato TANAKA, Satoru HIWA, Heiner ZILLE, Sanaz MOSTAGHIM and Tomoyuki HIROYASU
    • Organizer
      IEEE, Conference on Evolutionary Computation
    • Place of Presentation
      Vancouver Convention Centre (Vancouver, Canada)
    • Year and Date
      2016-07-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2016-04-21   Modified: 2023-03-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi