Bioinformatics analysis of disease attractors and gene regulatory networks of Alzheimer's disease
| Project/Area Number |
16K00385
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Life / Health / Medical informatics
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| Research Institution | Tohoku University |
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Principal Investigator |
Ogishima Soichi 東北大学, 東北メディカル・メガバンク機構, 教授 (40447496)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 生命情報 / 疾患アトラクター / アルツハイマー病 / 遺伝子調節ネットワーク / アルツハイマー |
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| Outline of Final Research Achievements |
We inferred attractors of disease state of Alzheimer’s disease (AD), conducted trajectory analysis of those attractors, and analyzed gene regulatory network forming those attractors. We then developed the algorithm to detect complex gene-environment (GxE) interactions causing AD. Using gene expression data of AD samples, we inferred probabilistic potentials of AD samples in the state space of AD gene expression data. We also inferred the corresponding gene regulatory network to AD attractors on probabilistic potentials.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は遺伝要因、環境要因が複雑に相互作用して発症する多因子疾患の機序の解明に向けて、アルツハイマー病において遺伝要因、生活習慣や環境暴露等の環境要因の複雑な相互作用(G×E)の推定手法の開発を行い、遺伝子発現の状態空間における細胞集団の遺伝子発現ポテンシャルの推定、疾患アトラクターの推定、疾患アトラクターを形成する遺伝子調節ネットワークの解析を行った。遺伝要因、環境要因が複雑に相互作用して発症する多因子疾患の機序を解明することに寄与する、新たな情報学的な手法を開発した。
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy2019
Author(s)
Sugawara J, Ochi D, Yamashita R, Yamauchi T, Saigusa D, Wagata M, Obara T, Ishikuro M, Tsunemoto Y, 18名略, Hiyama S, Nagasaki M
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Journal Title
BMJ Open
Volume: 9(2)
Issue: 2
Pages: e025939-e025939
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2,049 individuals2018
Author(s)
Y Yamaguchi-Kabata, J Yasuda, O Tanabe, Y Suzuki, H Kawame, N Fuse, M Nagasaki, Y Kawai, K Kojima, F Katsuoka, S Saito, I Danjoh, I Motoike, R Yamashita, S Koshiba, D Saigusa, G Tamiya, S Kure, N Yaegashi, Y Kawaguchi, F Nagami, S Kuriyama, J Sugawara, N Minegishi, A Hozawa, T Takai-Igarashi, K Kinoshita, M Yamamoto.
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Journal Title
Journal of Human Genetics.
Volume: 63
Issue: 2
Pages: 213-230
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Identification of six novel genetic loci associated with atrial fibrillation in Japanese population.2017
Author(s)
Low SK, Takahashi A, Ebana Y, Ozaki K, Christophersen IE, Ellinor PT, AFGen Consortium, Ogishima S, Yamamoto M, Satoh M, Sasaki M, Yamaji T, Iwasaki M, Tsugane S, Tanaka K, Naito M, Wakai K, Tanaka H, Furukawa T, Kubo M, Ito K, Kamatani Y, Tanaka T.
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Journal Title
Nature Genetics
Volume: -
Issue: 6
Pages: 953-958
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Security controls in an integrated Biobank to protect privacy in data sharing: rationale and study design2017
Author(s)
Takai-Igarashi T, Kinoshita K, Nagasaki M, Ogishima S, Nakamura N, Nagase S, Nagaie S, Saito T, Nagami F, Minegishi N, Suzuki Y, Suzuki K, Hashizume H, Kuriyama S, Hozawa A, Yaegashi N, Kure S, Tamiya G, Kawaguchi Y, Tanaka H, Yamamoto M
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Journal Title
BMC Med Inform Decis Mak
Volume: 17
Issue: 1
Pages: 100-100
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The Human Phenotype Ontology in 2017.2017
Author(s)
Kohler S, Vasilevsky NA, Engelstad M, Foster E, McMurry J, Ayme S, Baynam G, Bello SM, ... Ogishima S, ...Haendel M.
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Journal Title
Nucleic Acids Res
Volume: 45(D1)
Issue: D1
Pages: D865-D876
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The structural origin of metabolic quantitative diversity.2016
Author(s)
Koshiba S, Motoike I, Kojima K, Hasegawa T, Shirota M, Saito T, Saigusa D, Danjoh I, Katsuoka F, Ogishima S, ... Yamamoto M.
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Journal Title
Sci Rep
Volume: 6
Issue: 1
Pages: 31463-31463
DOI
Related Report
Peer Reviewed / Open Access
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