Advanced radiation research using comprehensive multi-high-throughput technologies
| Project/Area Number |
16K00547
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Hiroshima University |
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Principal Investigator |
Kawai Hidehiko 広島大学, 大学院医歯薬保健学研究科(薬), 准教授 (30379846)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 持続放射線照射 / ハイスループットスクリーニング / 細胞応答 / 細胞運命 |
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| Outline of Final Research Achievements |
Low dose and low dose-rate radiation-induced biological effects and their underlying mechanisms are not fully understood yet. In this research project, to better understand the biological effects of low dose and low dose-rate radiation exposures, we have obtained and analyzed comprehensive biological data using two different types of high-throughput techniques by subjecting various cultured cell lines to chronic gamma-irradiation in a facility to allow for exposure at a wide range of dose-rates. By using this complementary comprehensive multi-high-throughput approach, and different types of cell cultures, including primary cell lines, we have been able to identify several factors and cellular radiation responses involved in cell fate decisions and biological effects triggered by chronic gamma-irradiation.
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| Academic Significance and Societal Importance of the Research Achievements |
未だ不明な点が多い低線量（率）の放射線被曝の人体影響について、低線量率の持続放射線照射によって現れる細胞への影響と細胞の応答機構及びそれらに関与する、或いは、直接制御する複数の因子を明らかとすることができた。これらの因子と人体への影響やがんなどを含む疾病との関わりを新たな視点から研究することによって、今後、放射線影響の分子機構を解明することが可能となることが期待される。また、本研究によって、細胞老化を制御する因子を同定したことから、老化メカニズムの研究への貢献も期待される。
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Replication stress induces accumulation of FANCD2 at central region of large fragile genes.2018
Author(s)
Okamoto Y, Iwasaki WM, Kugou K, Takahashi KK, Oda A, Sato K, Kobayashi W, Kawai H, Sakasai R, Takaori-Kondo A, Yamamoto T, Kanemaki MT, Taoka M, Isobe T, Kurumizaka H, Innan H, Ohta K, Ishiai M, Takata M.
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Journal Title
Nucleic Acids Res.
Volume: 46(6)
Issue: 6
Pages: 2932-2944
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level.2017
Author(s)
Sasatani M, Xi Y, Kajimura J, Kawamura T, Piao J, Masuda Y, Honda H, Kubo K, Mikamoto T, Watanabe H, Xu Y, Kawai H, Shimura T, Noda A, Hamasaki K, Kusunoki Y, Zaharieva EK, Kamiya K.
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Journal Title
Carcinogenesis.
Volume: 38(5)
Issue: 5
Pages: 570-578
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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