| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Low dose and low dose-rate radiation-induced biological effects and their underlying mechanisms are not fully understood yet. In this research project, to better understand the biological effects of low dose and low dose-rate radiation exposures, we have obtained and analyzed comprehensive biological data using two different types of high-throughput techniques by subjecting various cultured cell lines to chronic gamma-irradiation in a facility to allow for exposure at a wide range of dose-rates. By using this complementary comprehensive multi-high-throughput approach, and different types of cell cultures, including primary cell lines, we have been able to identify several factors and cellular radiation responses involved in cell fate decisions and biological effects triggered by chronic gamma-irradiation.
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