Residues of Organic Fluorinated Water Repellants and Evaluation of Human Exposure
Project/Area Number |
16K00565
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Risk sciences of radiation and chemicals
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Research Institution | Daiichi University, College of Pharmaceutical Sciences |
Principal Investigator |
Fujii Yukiko 第一薬科大学, 薬学部, 講師 (80733542)
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Research Collaborator |
HARAGUCHI Koichi
KIMURA Osamu
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | 環境保健 / 体内動態 / 衛生学 / 有機フッ素化カルボン酸 / フッ素化カルボン酸 / 海洋汚染 / 環境動態 / 公衆衛生学 |
Outline of Final Research Achievements |
The aim of this study is to investigate of human exposure and environmental pollution of PFCAs and their potential precursors (e.g. PAPs) in Japan. The main conducted studies are as follows: 1) Long term trend of PFCAs in human serum and diet were monitored (1979-2011). 2) In order to reveal the relationship between human oral PFCAs intake and its blood concentration, we evaluated the intracellular uptake mechanism in Caco-2 cells. 3) PFCAs in tissues (in liver, fat and blood) of marine mammals was measured to obtain basic information of their tissue distribution. 4) The current concentration of PFCAs and PAPs in edible fish samples were monitored.
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Academic Significance and Societal Importance of the Research Achievements |
本研究では長期に環境中・生体中に残留する有機フッ素化合物について、ヒト血清中濃度の経年変化、ヒト小腸上皮細胞モデルの細胞内への取り込み機構、大型海洋哺乳類(鯨類)の組織別蓄積傾向、食用魚類の地域別蓄積傾向を明らかにした。環境中の微量化学物質を、ヒト体内負荷量・環境動態の双方から評価することは、環境中の存在量の変動とヒトへの影響の関連性を評価する上で重要である。結果として有機フッ素化合物は日本近海の魚類に多くの蓄積が見られた。日本は海産物の消費量が多いことから、環境保全のみならず、食の安全の観点からも継続的なモニタリングが求められる。
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Possible mechanism for the polychlorinated bipheny-linduced liver-selective accumulation of thyroxine in rats2017
Author(s)
Kato, Y.; Fujii, A.; Haraguchi, K.; Fujii, Y.; Atobe, K.; Endo, T.; Kimura, O.; Koga, N.; Ohta, C.; Yamada, S.; Degawa, M
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Journal Title
The Journal of Toxicological Sciences
Volume: 42
Issue: 6
Pages: 663-669
DOI
NAID
ISSN
0388-1350, 1880-3989
Related Report
Peer Reviewed
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[Journal Article] Levels, profiles and dietary sources of hydroxylated PCBs and hydroxylated and methoxylated PBDEs in Japanese women serum samples.2016
Author(s)
Haraguchi, K., Ito, Y., Takagi, M., Fujii, Y., Harada, K.H., Koizumi, A.
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Journal Title
Environment International
Volume: 97
Pages: 155-162
DOI
Related Report
Peer Reviewed
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[Presentation] Edible fish is a source of human dietary exposure: perfluorinated alkyl acids in Pacific cods from North Pacific Ocean.2018
Author(s)
Fujii Y, Haraguchi K, Kato Y, Ohta C, Koga N, Kimura O, Endo T, Harada KH, Koizumi A
Organizer
Dioxin2018, Krakow, Poland
Related Report
Int'l Joint Research
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[Presentation] In vitro metabolism of 2,2',3,4',5,6,6'-heptachlorobiphenyl (CB188) by rat liver microsomes.2018
Author(s)
Ohta C, Yamamoto K, Fujii Y, Haraguchi K, Kimura O, Endo T, Kato Y, Koga N
Organizer
Dioxin2018, Krakow, Poland
Related Report
Int'l Joint Research
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[Presentation] Involvement of transthyretin to Kanechlor-500-mediated changes in serum and hepatic thyroxine levels in mice2018
Author(s)
Kato Y, Tamaki S, Haraguchi K, Fujii Y, Kimura O, Ohta C, Endo T, Koga N, Degawa M
Organizer
Dioxin2018, Krakow, Poland
Related Report
Int'l Joint Research
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[Presentation] 2,2',3,4,4',5,6'-七塩素化ビフェニル(PCB182)の動物およびヒト肝ミクロゾームによる代謝2017
Author(s)
太田 千穂, 藤井 由希子, 原口 浩一, 加藤 善久, 木村 治, 遠藤 哲也, 古賀 信幸
Organizer
日本薬学会第137回年会
Place of Presentation
仙台国際センター
Year and Date
2017-03-24
Related Report
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[Presentation] The levels and trends of POPs and perfluorinated carboxylic acids in fish and marine mammals from Japanese coastal waters2016
Author(s)
Fujii Y, Haraguchi K, Kato Y, Kimura O, Endo T, Ohta C, Koga N, Harada K, Koizumi A
Organizer
Dioxin2016
Place of Presentation
Congress and Exhibition Center, Florence, Italy
Year and Date
2016-08-28
Related Report
Int'l Joint Research
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[Presentation] Metabolism of 2,2‘,3,4,4’,5,6‘-heptachlorobiphenyl(CB182)by rat, guinea pig and human liver microsomes2016
Author(s)
Ohta C, Fujii Y, Haraguchi K, Kato Y, Kimura O, Endo T, Koga N, Metabolism of 2,2‘,3,4,4’,5,6‘-heptachlorobiphenyl(CB182)by rat, guinea pig and human liver microsomes
Organizer
Dioxin2016
Place of Presentation
Congress and Exhibition Center, Florence, Italy
Year and Date
2016-08-28
Related Report
Int'l Joint Research
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[Presentation] Induction of hepatic T4 transporters by polychlorinated biphenyl in rats2016
Author(s)
Kato Y, Haraguchi K, Fujii A, Fujii Y, Kimura O, Ohta C, Endo T, Koga N, Yamada S, and Degawa M
Organizer
Dioxin2016
Place of Presentation
Congress and Exhibition Center, Florence, Italy
Year and Date
2016-08-28
Related Report
Int'l Joint Research
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