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Residues of Organic Fluorinated Water Repellants and Evaluation of Human Exposure

Research Project

Project/Area Number 16K00565
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Risk sciences of radiation and chemicals
Research InstitutionDaiichi University, College of Pharmaceutical Sciences

Principal Investigator

Fujii Yukiko  第一薬科大学, 薬学部, 講師 (80733542)

Research Collaborator HARAGUCHI Koichi  
KIMURA Osamu  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords環境保健 / 体内動態 / 衛生学 / 有機フッ素化カルボン酸 / フッ素化カルボン酸 / 海洋汚染 / 環境動態 / 公衆衛生学
Outline of Final Research Achievements

The aim of this study is to investigate of human exposure and environmental pollution of PFCAs and their potential precursors (e.g. PAPs) in Japan. The main conducted studies are as follows: 1) Long term trend of PFCAs in human serum and diet were monitored (1979-2011). 2) In order to reveal the relationship between human oral PFCAs intake and its blood concentration, we evaluated the intracellular uptake mechanism in Caco-2 cells. 3) PFCAs in tissues (in liver, fat and blood) of marine mammals was measured to obtain basic information of their tissue distribution. 4) The current concentration of PFCAs and PAPs in edible fish samples were monitored.

Academic Significance and Societal Importance of the Research Achievements

本研究では長期に環境中・生体中に残留する有機フッ素化合物について、ヒト血清中濃度の経年変化、ヒト小腸上皮細胞モデルの細胞内への取り込み機構、大型海洋哺乳類(鯨類)の組織別蓄積傾向、食用魚類の地域別蓄積傾向を明らかにした。環境中の微量化学物質を、ヒト体内負荷量・環境動態の双方から評価することは、環境中の存在量の変動とヒトへの影響の関連性を評価する上で重要である。結果として有機フッ素化合物は日本近海の魚類に多くの蓄積が見られた。日本は海産物の消費量が多いことから、環境保全のみならず、食の安全の観点からも継続的なモニタリングが求められる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (46 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (4 results) Journal Article (12 results) (of which Peer Reviewed: 12 results,  Acknowledgement Compliant: 3 results) Presentation (30 results) (of which Int'l Joint Research: 10 results)

  • [Int'l Joint Research] 国立台湾海洋大学(中国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] アントワープ大学(ベルギー)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] 台湾国立海洋大学(中華民国(台湾))

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] アントワープ大学(ベルギー)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Levels and profiles of long-chain perfluoroalkyl carboxylic acids in Pacific cod from 14 sites in the North Pacific Ocean2019

    • Author(s)
      Fujii Yukiko、Tuda Hayato、Kato Yoshihisa、Kimura Osamu、Endo Tetsuya、Harada Kouji H.、Koizumi Akio、Haraguchi Koichi
    • Journal Title

      Environmental Pollution

      Volume: 247 Pages: 312-318

    • DOI

      10.1016/j.envpol.2019.01.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different profiles of naturally produced and anthropogenic organohalogens in the livers of cetaceans from the Sea of Japan and the North Pacific Ocean2018

    • Author(s)
      Fujii Yukiko、Kato Yoshihisa、Kozai Mai、Matsuishi Takashi、Harada Kouji H.、Koizumi Akio、Kimura Osamu、Endo Tetsuya、Haraguchi Koichi
    • Journal Title

      Marine Pollution Bulletin

      Volume: 136 Pages: 230-242

    • DOI

      10.1016/j.marpolbul.2018.08.051

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contamination trends and factors affecting the transfer of hexabromocyclododecane diastereomers, tetrabromobisphenol A, and 2,4,6-tribromophenol to breast milk in Japan.2018

    • Author(s)
      Fujii Y, Kato Y, Masuda N, Harada KH, Koizumi A, Haraguchi K.
    • Journal Title

      Environmental Pollution

      Volume: 237 Pages: 936-943

    • DOI

      10.1016/j.envpol.2018.03.015

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of radiocesium and stable isotope ratios of carbon and nitrogen among three stocks of Pacific cod (Gadus macrocephalus) around Hokkaido, Japan2018

    • Author(s)
      Nakamura Tsugiya、Tanaka Toshiyasu、Kimura Osamu、Fujii Yukiko、Haraguchi Koichi、Endo Tetsuya
    • Journal Title

      Marine Pollution Bulletin

      Volume: 127 Pages: 39-44

    • DOI

      10.1016/j.marpolbul.2017.11.029

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tissue-specific bioaccumulation of long-chain perfluorinated carboxylic acids and halogenated methylbipyrroles in Dall's porpoises ( Phocoenoides dalli ) and harbor porpoises ( Phocoena phocoena ) stranded in northern Japan2018

    • Author(s)
      Fujii Yukiko、Kato Yoshihisa、Sakamoto Kentarou、Matsuishi Takashi、Kouji Harada、Koizumi Akio、Kimura Osamu、Endo Tetsuya、Haraguchi Koichi
    • Journal Title

      Science of The Total Environment

      Volume: 616-617 Pages: 554-563

    • DOI

      10.1016/j.scitotenv.2017.10.033

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Growth-related changes in non-essential and essential metals in the liver of star-spotted smooth-hounds (dogfish) Mustelus manazo from the northern region of Japan2017

    • Author(s)
      Endo Tetsuya、Kimura Osamu、Terasaki Masaru、Fujii Yukiko、Haraguchi Koichi、Ohta Chiho、Koga Nobuyuki、Kato Yoshihisa
    • Journal Title

      Marine Environmental Research

      Volume: 131 Pages: 156-161

    • DOI

      10.1016/j.marenvres.2017.09.009

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Possible mechanism for the polychlorinated bipheny-linduced liver-selective accumulation of thyroxine in rats2017

    • Author(s)
      Kato, Y.; Fujii, A.; Haraguchi, K.; Fujii, Y.; Atobe, K.; Endo, T.; Kimura, O.; Koga, N.; Ohta, C.; Yamada, S.; Degawa, M
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 42 Issue: 6 Pages: 663-669

    • DOI

      10.2131/jts.42.663

    • NAID

      130006206264

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 2,2',3,4,4',5,6'-七塩素化ビフェニル(CB182)のラット,モルモットおよびヒト肝ミクロゾームによる代謝2017

    • Author(s)
      太田 千穂 藤井 由希子 原口 浩一 加藤 善久 木村 治 遠藤 哲也 古賀 信幸
    • Journal Title

      Fukuoka Acta Medica

      Volume: 106 Pages: 176-183

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term trends in dietary intake of perfluoroalkyl carboxylic acids in relation to their serum concentration in two regions in Japan from 1979 to 20112017

    • Author(s)
      Fujii, Y.; Harada, K. H.; Haraguchi, K.; Koizumi, A.
    • Journal Title

      Chemosphere

      Volume: 176 Pages: 165-174

    • DOI

      10.1016/j.chemosphere.2017.02.073

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Uptake of perfluorooctanoic acid by Caco-2 cells: Involvement of organic anion transporting polypeptides2017

    • Author(s)
      Kimura O,Fujii Y, Haraguchi K,Kato Y, Ohta C, Koga N, Endo, T
    • Journal Title

      Toxicology Letters

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Levels, profiles and dietary sources of hydroxylated PCBs and hydroxylated and methoxylated PBDEs in Japanese women serum samples.2016

    • Author(s)
      Haraguchi, K., Ito, Y., Takagi, M., Fujii, Y., Harada, K.H., Koizumi, A.
    • Journal Title

      Environment International

      Volume: 97 Pages: 155-162

    • DOI

      10.1016/j.envint.2016.08.022

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between mercury, organochlorine compounds and stable isotope ratios of carbon and nitrogen in yellowfin tuna (Thunnus albacares) taken from different regions of the Pacific and Indian Oceans.2016

    • Author(s)
      Endo, T., Kimura, O., Fujii, Y., Haraguchi, K.
    • Journal Title

      Ecological Indicators.

      Volume: 69 Pages: 340-347

    • DOI

      10.1016/j.ecolind.2016.04.021

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 北太平洋海域諸国における有機フッ素化合物の食用魚類を通じた摂取量評価2019

    • Author(s)
      安藤 順平, 永田 滋, 津田 侑人, 藤井 由希子, 加藤 善久, 木村 治, 遠藤 哲也, 太田 千穂, 古賀 信幸, 原口 浩一
    • Organizer
      第139回 日本薬学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Caco-2 細胞におけるロスバスタチンの膜透過に及ぼす 5,7- ジメトキシフラボンの影響2019

    • Author(s)
      木村 治, 太田 千穂, 古賀 信幸, 加藤 善久, 藤井 由希子, 原口 浩一, 遠藤 哲也
    • Organizer
      第139回 日本薬学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ラット肝酵素による PCB188 の水酸化反応2019

    • Author(s)
      太田 千穂, 山本 健太, 加藤 善久, 藤井 由希子, 原口 浩一, 木村 治, 遠藤 哲也, 古賀 信幸
    • Organizer
      第139回 日本薬学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 食用魚類に含まれる残留性長鎖有機フッ素カルボン酸の分析2018

    • Author(s)
      津田侑人、中村翼、碇元貴士、府髙昌才輝、藤井由希子、加藤善久、木村治、遠藤哲也、太田千穂、古賀信幸、原口浩一
    • Organizer
      第138回 日本薬学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Caco-2細胞におけるBSPの取り込みに及ぼすペルフルオロカルボン酸化合物の影響2018

    • Author(s)
      木村 治、藤井由希子、原口浩一、加藤善久、太田千穂、古賀信幸、遠藤哲也
    • Organizer
      第138回 日本薬学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アブラツノザメ、ホシザメ、イタチザメおよびツマジロザメの成長に伴う酸素安定同位体比の変化と性差について2018

    • Author(s)
      遠藤哲也、木村治、寺崎将、藤井由希子、原口浩一
    • Organizer
      第138回日本薬学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Edible fish is a source of human dietary exposure: perfluorinated alkyl acids in Pacific cods from North Pacific Ocean.2018

    • Author(s)
      Fujii Y, Haraguchi K, Kato Y, Ohta C, Koga N, Kimura O, Endo T, Harada KH, Koizumi A
    • Organizer
      Dioxin2018, Krakow, Poland
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vitro metabolism of 2,2',3,4',5,6,6'-heptachlorobiphenyl (CB188) by rat liver microsomes.2018

    • Author(s)
      Ohta C, Yamamoto K, Fujii Y, Haraguchi K, Kimura O, Endo T, Kato Y, Koga N
    • Organizer
      Dioxin2018, Krakow, Poland
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Involvement of transthyretin to Kanechlor-500-mediated changes in serum and hepatic thyroxine levels in mice2018

    • Author(s)
      Kato Y, Tamaki S, Haraguchi K, Fujii Y, Kimura O, Ohta C, Endo T, Koga N, Degawa M
    • Organizer
      Dioxin2018, Krakow, Poland
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Human exposure to brominated phenoxy phenols: seaweeds as source of hydroxylated and methoxylated PBDEs in Asia-Pacific.2018

    • Author(s)
      Haraguchi K, Fujii Y, Ohta C, Koga N, Kimura O, Endo T, Kato Y:
    • Organizer
      Dioxin2018, Krakow, Poland
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 北海道に棲息する海洋哺乳類におけるハロゲン化ビピロール類および長鎖ペルフルオロカルボン酸の濃度とその組織別蓄積傾向2018

    • Author(s)
      藤井 由希子、加藤 善久、木村 治、遠藤 哲也、原口 浩一.
    • Organizer
      分析化学会第67年会 仙台
    • Related Report
      2018 Annual Research Report
  • [Presentation] 食用魚類に含まれる残留性長鎖有機フッ素カルボン酸の分析2018

    • Author(s)
      津田侑人、中村翼、碇元貴士、府髙昌才輝、藤井由希子、加藤善久、木村治、遠藤哲也、太田千穂、古賀信幸、原口浩一
    • Organizer
      日本薬学会第138回年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Caco-2細胞におけるBSPの取り込みに及ぼすペルフルオロカルボン酸化合物の影響2018

    • Author(s)
      木村 治、藤井由希子、原口浩一、加藤善久、太田千穂、古賀信幸、遠藤哲也
    • Organizer
      日本薬学会第138回年会
    • Related Report
      2017 Research-status Report
  • [Presentation] アブラツノザメ、ホシザメ、イタチザメおよびツマジロザメの成長に伴う酸素安定同位体比の変化と性差について2018

    • Author(s)
      遠藤哲也、木村治、寺崎将、藤井由希子、原口浩一
    • Organizer
      平成30年度日本水産学会春季大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ホシザメの成長に伴う肝臓中のCdと必須金属濃度の変化2017

    • Author(s)
      遠藤哲也・木村 治・寺崎 将・加藤善久・藤井由希子・原口浩一・太田千穂・古賀信幸
    • Organizer
      平成29年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学
    • Year and Date
      2017-03-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 抗菌剤トリクロサンの腸内細菌叢への影響評価2017

    • Author(s)
      藤井由希子、久我歩佳、木下真璃伽、加藤善久、太田千穂、古賀信幸、木村 治、遠藤哲也、原口浩一
    • Organizer
      日本薬学会第137回年会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 亜熱帯植物モリンガ葉に由来するフラボノイド配糖体の抗酸化機能の評価2017

    • Author(s)
      大坪 雅英, 藤井 由希子, 都築 稔, 原口 浩一, 岩部 耕一郎, 溝田 尚大
    • Organizer
      日本薬学会第137回年会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 2,2',3,4,4',5,6'-七塩素化ビフェニル(PCB182)の動物およびヒト肝ミクロゾームによる代謝2017

    • Author(s)
      太田 千穂, 藤井 由希子, 原口 浩一, 加藤 善久, 木村 治, 遠藤 哲也, 古賀 信幸
    • Organizer
      日本薬学会第137回年会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 海洋生物由来のフェノール性臭素化合物によるエストロゲンシグナルかく乱作用の解析2017

    • Author(s)
      岡﨑裕之、池田(高露)恵理子、水之江来夢、松尾紗樹、古田恵梨果、竹田修三、藤井由希子、原口浩一、渡辺和人、荒牧弘範
    • Organizer
      日本薬学会第137回年会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] Caco-2細胞におけるペルフルオロオクタン酸の取り込み2017

    • Author(s)
      木村治、藤井由希子、原口浩一、加藤喜久、太田千穂、古賀信幸、遠藤哲也
    • Organizer
      日本薬学会第137回年会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 海藻 (Sargassum fusiforme) に含有される臭素化ビフェノール(6-OH-BDE47)の抗菌作用2017

    • Author(s)
      藤井 由希子,小川 和加野,松原 大,原口 浩一
    • Organizer
      第51回ビブリオシンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] Brominated catechols and guaiacols as possible sources of dihydroxylated  PBDEs and hydroxylated dioxins in bivalves from Asia-Pacific.2017

    • Author(s)
      Koichi Haraguchi, Yukiko Fujii, Osamu Kimura, Tetsuya Endo, Yoshihisa Kato, Chiho Ohta, Nobuyuki Koga
    • Organizer
      Dioxin 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Tissue-specific bioaccumulation of halogenated methylbipyrroles and long-chain perfluorinated carboxylic acids in marine mammals stranded in northern Japan2017

    • Author(s)
      Yukiko Fujii, Yoshihisa Kato, Osamu Kimura, Tetsuya Endo, Chiho Ohta, Nobuyuki Koga, Kouji H Harada, Akio Koizumi, Koichi Haraguchi.
    • Organizer
      Dioxin 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Uptake of perfluorooctanoic acid into human intestinal Caco-2 cells by organic anion transporting polypeptide2017

    • Author(s)
      Kimura O, Fujii Y, Haraguchi K, Kato Y, Ohta C, Koga N, Endo T
    • Organizer
      Dioxin 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 環境化学物質による女性ホルモン機能の修飾メカニズム2017

    • Author(s)
      岡﨑 裕之、竹田 修三、藤井 由希子、原口 浩一、 渡辺 和人、荒牧 弘範
    • Organizer
      第44回日本毒性学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 泌乳期マウスにおける消毒薬トリクロサンの体内動態2016

    • Author(s)
      久我歩佳、木下真璃伽、藤井由希子、原口浩一
    • Organizer
      第33回日本薬学会九州支部大会
    • Place of Presentation
      鹿児島大学
    • Year and Date
      2016-12-03
    • Related Report
      2016 Research-status Report
  • [Presentation] The levels and trends of POPs and perfluorinated carboxylic acids in fish and marine mammals from Japanese coastal waters2016

    • Author(s)
      Fujii Y, Haraguchi K, Kato Y, Kimura O, Endo T, Ohta C, Koga N, Harada K, Koizumi A
    • Organizer
      Dioxin2016
    • Place of Presentation
      Congress and Exhibition Center, Florence, Italy
    • Year and Date
      2016-08-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Metabolism of 2,2‘,3,4,4’,5,6‘-heptachlorobiphenyl(CB182)by rat, guinea pig and human liver microsomes2016

    • Author(s)
      Ohta C, Fujii Y, Haraguchi K, Kato Y, Kimura O, Endo T, Koga N, Metabolism of 2,2‘,3,4,4’,5,6‘-heptachlorobiphenyl(CB182)by rat, guinea pig and human liver microsomes
    • Organizer
      Dioxin2016
    • Place of Presentation
      Congress and Exhibition Center, Florence, Italy
    • Year and Date
      2016-08-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Induction of hepatic T4 transporters by polychlorinated biphenyl in rats2016

    • Author(s)
      Kato Y, Haraguchi K, Fujii A, Fujii Y, Kimura O, Ohta C, Endo T, Koga N, Yamada S, and Degawa M
    • Organizer
      Dioxin2016
    • Place of Presentation
      Congress and Exhibition Center, Florence, Italy
    • Year and Date
      2016-08-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Gossypetin hexamethyletherの動物肝ミクロゾームによる代謝2016

    • Author(s)
      太田千穂、山本健太、藤井由希子、原口浩一、木村 治、遠藤哲也、加藤善久、古賀信幸
    • Organizer
      第70回日本栄養・食糧学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2022-02-22  

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