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A novel approach for evaluation of environmental pollutant-induced developmental neurotoxicity using non-invasive MRI technique

Research Project

Project/Area Number 16K00577
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental impact assessment
Research InstitutionNational Institute for Environmental Studies

Principal Investigator

Win-Shwe Tin-Tin  国立研究開発法人国立環境研究所, 環境リスク・健康研究センター, 主任研究員 (00391128)

Co-Investigator(Kenkyū-buntansha) 渡邉 英宏  国立研究開発法人国立環境研究所, 環境計測研究センター, 主任研究員 (60370269)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords環境汚染物質 / 発達神経毒性 / ラット / MRI / 神経毒性 / 発達期 / 二次生成有機エアロゾル / 自閉症モデル / 発達期曝露 / 脳神経
Outline of Final Research Achievements

In recent years, the prevalence of developmental disorders such as autism spectrum disorder (ASD) and Alzheimer's disease are increasing, but the cause is still unknown. Both genetic and environmental factors are considered for the etiology of ASD. The gaseous components contained in the atmosphere are oxidized to form a secondary organic aerosol (SOA). In this study, we investigated the social behavior and related gene expression of valproic acid-induced autism model rats and rats exposed to the SOA derived from diesel exhaust during developmental period. We also used technologically advanced non-invasiveness imaging MRI method to evaluate changes in the brain.

Academic Significance and Societal Importance of the Research Achievements

医学および生物学における動物の使用は不可欠ですが、研究者は使用される数を減らし、それらの使用方法を改善するために積極的に取り組んでいる。 このMRI法は実験のために動物を減らし、再利用しそしてリサイクルするのに適している。動物との実験方法を改善すると、結果の信頼性が高まり、また実験がより人道的で効率的になる。イメージングを使用することにより、個々の動物の寿命を通して病気の進行を見ることができ、したがって使用される数を劇的に減らすことができる。イメージングはまた、一度にいくつかのバイオマーカーを見ることにより、単一の実験でより多くの質問に答える可能性を提供する。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2019 2018 2017

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (14 results) (of which Int'l Joint Research: 9 results,  Invited: 3 results)

  • [Journal Article] Effects of diesel exhaust derived secondary organic aerosol (DE-SOA) exposure during developmental period on anxiety and depression in mice2019

    • Author(s)
      Tin-Tin Win-Shwe, Yuji Fujitani, Seishiro Hirano
    • Journal Title

      Indoor Environment

      Volume: 22 Pages: 23-32

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Social behavior, neuroimmune markers and glutamic acid decarboxylase levels in a rat model of valproic acid-induced autism2018

    • Author(s)
      Tin-Tin Win-Shwe, Nay Chi Nway, Motoki Imai, Thet Thet Lwin, Ohn Mar、 Hidehiro Watanabe
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 43 Issue: 11 Pages: 631-643

    • DOI

      10.2131/jts.43.631

    • NAID

      130007506544

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of TLR4 in olfactory-based spatial learning activity of neonatal mice after developmental exposure to diesel exhaust origin secondary organic aerosol.2017

    • Author(s)
      4)Nay Chi Nway, Yuji Fujitani, Seishiro Hirano, Ohn Mar, Tin-Tin Win-Shwe
    • Journal Title

      Neurotoxicology

      Volume: 63 Pages: 155-165

    • DOI

      10.1016/j.neuro.2017.10.001

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neurotoxicity Assessment of Secondary Organic Aerosols by Intranasal and Inhalation Exposure in Mice2017

    • Author(s)
      2)Tin-Tin Win-Shwe, Fujitani Y, Hirano S
    • Journal Title

      Earozoru Kenkyu

      Volume: 32 Issue: 3 Pages: 169-175

    • DOI

      10.11203/jar.32.169

    • NAID

      130006138838

    • ISSN
      0912-2834, 1881-543X
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Social dominace behaviorand brain biomarkers after gestational and lactational exposure to secondary organic aerosol in male rats2019

    • Author(s)
      Tin-Tin Win-Shwe, Yuji Fujitani, Seishiro Hirano
    • Organizer
      47th Myanmar Health Research Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Environment and Health: Clean Environment, Better Health. “Air pollution and health risk: Running collaborative research between NIES and UM1 (1)”2019

    • Author(s)
      Tin-Tin Win-Shwe, Yuji Fujitani, Seishiro Hirano
    • Organizer
      47th Myanmar Health Research Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Monitoring of PM2.5 concentration in Yangon City, Myanmar2019

    • Author(s)
      14)Tin-Tin Win-Shwe, Ei Ei Pan Nu Yi, Win Yu Aung, Nay Chi Nway, Thet Hnin Wai, Zarli Thant, Cherry Maung, Kyu Kyu Hlaing, Mayuko Yagishita, Yang Ishigaki, Daisuke Nakajima, Ohn Mar
    • Organizer
      4th NIES International Forum
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Developmental exposure to secondary organic aerosol alters social dominace behavior and expression of neuroimmune biomarkers in rats2018

    • Author(s)
      Tin-Tin Win-Shwe, Nay Chi Nway, Ohn Mar, Hidehiro Watanabe, Yuji Fujitani, Seishiro Hirano
    • Organizer
      27th Symposium on Japan Environmental Chemistry
    • Related Report
      2018 Annual Research Report
  • [Presentation] Prenatal exposure to secondary organic aerosol influences neurbehavioral development and inflammatory markers in rats2018

    • Author(s)
      Tin-Tin Win-Shwe, Yuji Fujitani, Seishiro Hirano
    • Organizer
      54th Congress of European Society of Toxicology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Social behavior and neuroimmune responses in valproic acid exposed autistic rat models2018

    • Author(s)
      Tin-Tin Win-Shwe
    • Organizer
      41st Annual Meeting of the olecular Biology Society of Japan
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Phase contrast X-ray tomography brain imaging of rat model autism.2018

    • Author(s)
      Thet Thet Lwin, Tin-Tin Win-Shwe, Motoki Imai Hidehiro Watanabe, Hiroko Maruyama, Tohoru Takeda
    • Organizer
      46th Myanmar Health Research Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Expression of inflammatory markers and glutamic acid decarboxylase level in a rat model of valproic acid induced autism.2018

    • Author(s)
      Tin-Tin Win-Shwe, Motoki Imai, Nay Chi Nway, Thet-Thet-Lwin, Ohn Mar, Hidehiro Watanabe
    • Organizer
      46th Myanmar Health Research Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] ミクロ~マクロ(グローバル)な視点でPM2.5の健康影響を評価する: 動物モデルを用いた大気汚染物質曝露の脳神経系に及ぼす影響。2018

    • Author(s)
      Tin-Tin Win-Shwe
    • Organizer
      第88回日本衛生学会学術総会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Social behavior and related gene expressions in fragile X mental retardation 1 (Fmr1) gene knockout and valproic acid (VPA)-induced autism rat models2017

    • Author(s)
      Tin-Tin-Win-Shwe
    • Organizer
      45th Myanmar Health Research Congress
    • Place of Presentation
      Yangon, Myanmar
    • Year and Date
      2017-01-09
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ディーゼル排気ガス由来二次生成有機エアロゾル(DE-SOA) の発達期曝露がラットの脳神経系に及ぼす影響2017

    • Author(s)
      Tin-Tin Win-Shwe, 藤谷雄二, 平野靖史郎
    • Organizer
      第58回大気環境学会年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Using phase contrast X-ray computed tomography imaging for valproic acid rat model of autistic brain.2017

    • Author(s)
      Thet Thet Lwin, Yoneyama A, Tin-Tin Win-Shwe, Watanabe H, Imai M, Maruyama H, Huodo K, Takeda T
    • Organizer
      10th World Congress on Developmental Origins of Health and Disease
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Alteration of social behavior and glutamic acid decarboxylase level in the valproic acid-induced autism rat model.2017

    • Author(s)
      Tin-Tin Win-Shwe, Imai M, Nway NC, Lwin TT, Mar O, Maruyama H, Kawakami F, Watanabe H
    • Organizer
      10th World Congress on Developmental Origins of Health and Disease
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 「大気汚染物質に関する健康影響評価研究の最新動向:越境大気汚染から国内起源まで」2017

    • Author(s)
      Tin-Tin-Win-Shwe
    • Organizer
      44th Annual Meeting of Japanese Society of Toxicology
    • Related Report
      2017 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2020-03-30  

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