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Antimicrobial resistance and their impact of microbial ecosystem in urban river and pond

Research Project

Project/Area Number 16K00604
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Modeling and technologies for environmental conservation and remediation
Research InstitutionChuo University

Principal Investigator

Nishikawa Kahoko  中央大学, 商学部, 教授 (20345416)

Co-Investigator(Kenkyū-buntansha) 鈴木 孝昌  国立医薬品食品衛生研究所, 遺伝子医薬部, 室長 (30226526)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords薬剤耐性 / 表層水 / 河川 / 薬剤耐性菌 / 抗菌剤 / 細菌叢 / メタゲノム / 抗生物質 / 環境毒性
Outline of Final Research Achievements

Antimicrobial resistant bacteria (ARB) were detected in the urban surface water of all survey points (20 sites) in Tokyo. More than half of ARB are resistant to two or more antimicrobial agents. Especially, resistance to ampicillin with sulbactam (62%) and clarithromycin (54%) was frequently detected; both are used in the clinical setting for a long time, more than 25 years in Japan. Furthermore, we detected a huge amount of antimicrobial resistance (AMR) gene from surface water. The most frequent AMR genes were related to β-lactam, which are a class of broad-spectrum antibiotics. These AMR genes are a critical problem for the treatment of infectious disease. Consequently, it is considered that human antimicrobial use has an impact on AMR in surface water.

Academic Significance and Societal Importance of the Research Achievements

抗菌剤の使用が世界的に増大したことにより、多剤薬剤耐性菌が出現しやすくなっている。現在、世界で70万人の人々が薬剤耐性による感染症で死亡したと推定されており、この状態を改善するために、わが国も2016年から2020年の5年間で「薬剤耐性(AMR)対策アクションプラン」を実施している。人、動物、環境の3分野が総合的に対策を行う「ワンヘルス・アプローチ」が重要だが、日本においては環境分野の調査が進んでいない。そこで、本研究では大都市東京における川や池における薬剤耐性の分布やその特徴を調査し、今後の薬剤耐性へどのようなアプローチが必要か検討する知見を得る。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] Survey on antimicrobial-resistant bacteria in surface water in Tokyo2018

    • Author(s)
      蜂谷真基 金子直樹 西川可穂子
    • Journal Title

      Papers on Environmental Information Science

      Volume: ceis32 Issue: 0 Pages: 313-316

    • DOI

      10.11492/ceispapers.ceis32.0_313

    • NAID

      130007528191

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Resistome analysis of surface water from two ponds and two rivers in Tokyo.2018

    • Author(s)
      Kahoko NISHIKAWA, Takayoshi SUZUKI
    • Organizer
      SETAC Europe 28th Annual meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 河川の環境DNAから読み解く薬剤耐性の現状とその考え方2018

    • Author(s)
      西川可穂子
    • Organizer
      日本水環境学会シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 抗菌薬適正使用のための効果的な方法とは2018

    • Author(s)
      小山 優花、 西川可穂子
    • Organizer
      第15回 環境情報科学ポスターセッション
    • Related Report
      2018 Annual Research Report
  • [Presentation] 東京都内医師会の抗菌剤適正使用に関する啓発活動 ~HPから見る活動状況~2018

    • Author(s)
      金子直樹、西川可穂子
    • Organizer
      第15回 環境情報科学ポスターセッション
    • Related Report
      2018 Annual Research Report
  • [Presentation] 東京都内の表層水に含まれる薬剤耐性菌に関する調査2018

    • Author(s)
      蜂谷真基 金子直樹、西川可穂子
    • Organizer
      第32回環境情報科学学術研究論文発表会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Frequency of antimicrobial resistance in bacteria at urban pond and river in Tokyo2017

    • Author(s)
      K Nishikawa, T Suzuki, T Iwai, Y Koyama, N Kaneko, M Hachiya
    • Organizer
      The 18th International Conference on Diffuse Pollution and Eutrophication
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 環境中における耐性菌の分布とメタゲノム解析から見える微生物生態系への影響2017

    • Author(s)
      西川可穂子
    • Organizer
      日本製薬工業協会 第23回環境安全セミナー
    • Related Report
      2017 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2021-01-27  

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