| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Bisphenol A (BPA) is included in plastics as a plasticizer widely. BPA is an endocrine disrupting chemical (EDC) that promotes a female-inducing phenotype in genital organs via estrogen receptors. BPA is a typical EDC that can cross the blood-brain barrier (BBB) due to its hydrophobic character, and neurons or glial cells can be affected in a BPA-specific manner. In cell-based assays, we also discovered that BPA is an inducer of neurite outgrowth in PC12 cells when we add lower dose. A molecular analysis showed that acetylation of in histones was led to epigenetic regulation of gene expression.
Based on these results, we suggest that intracellular signaling caused by BPA is mediated via the histone modification to extend the neurites.
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