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Utilization of hydroperoxy lipid-reducing foodstuff in Food processing and cooking

Research Project

Project/Area Number 16K00815
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionKonan Women's University

Principal Investigator

Terao Junji  甲南女子大学, 医療栄養学部, 教授 (60093275)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords過酸化脂質 / 還元作用 / 食品機能 / 酸化ストレス / 抗酸化活性 / ネギ属 / 抗酸化作用
Outline of Final Research Achievements

The content of peroxidized lipids in the cooked foods should be hold at the lowest level to prevent the oxidative injury in the postprandial process including digestion Therefore, this study aimed to develop a new method for minimizing the peroxidized lipid by the use of lipid hydroperoxide-reducing activity of onion-family vegetables. It was found that green onion possesses higher hydroperoxy-linoleic acid-reducing activity than welsh onion, onion and garlic. Artificial pancreatic juice-dependent hydrolysis of hydroperoxy-triacylglycerol (TG-OOH) generated hydroperoxy-free fatty acids (FFA-OOH). However, simultaneous addition of gree onion sample did not reduce neither TG-OOH nor FFA-OOH. In the digestive tract, it is likely that active components of green onion is digested to lose their hydroperoxide-reducing activity. Further study is required to overcome this problem for the practical uses of green onion-derived onion active component for new antioxidant ingredient.

Academic Significance and Societal Importance of the Research Achievements

生体内で発生する過酸化脂質に関しては多くの研究業績があり、その本体であるヒドロペルオキシド(LOOH)を還元消去する酵素群も明らかになっている。しかし、毒性が問題となる食品由来過酸化脂質の低減化方法にLOOH還元消去能は利用されていない。本研究は安全なLOOH還元消去物質を食材からスクリーニングし、ネギ属野菜が新規の抗酸化作用としてグルタチオンペルオキシダーゼ様のLOOH還元能をもつことを明らかにした。食材が有するLOOH還元能は、調理加工過程で脂質含有食材に混合させることや、食事における組み合わせに応用することにより、健全な「低過酸化脂質食」を作出することができる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2019 2018 2017

All Journal Article (5 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (1 results) Funded Workshop (1 results)

  • [Journal Article] Role of intestinal microbiota in the bioavailability and physiological functions of dietary polyphenols2019

    • Author(s)
      Kawabata K., Yoshioka Y., Terao J.
    • Journal Title

      Molecules

      Volume: 24 Pages: 00-00

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibitory effect of catecholic colonic metabolites of rutin on fatty acid hydroperoxide and hemoglobin dependent lipid peroxidation in Caco-2 cells2018

    • Author(s)
      Morales AM, Mukai R., Murota K.、Terao J.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 63 Issue: 3 Pages: 175-180

    • DOI

      10.3164/jcbn.18-38

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 抗酸化ポリフェノールの体内動態と機能性発現機構2018

    • Author(s)
      寺尾純二
    • Journal Title

      アグリバイオ

      Volume: 2 Pages: 748-752

    • Related Report
      2018 Annual Research Report
  • [Journal Article] ポリフェノール研究の現状と未来2017

    • Author(s)
      寺尾純二
    • Journal Title

      日本ポリフェノール学会雑誌

      Volume: 6 Pages: 7-10

    • NAID

      40021253409

    • Related Report
      2017 Research-status Report
  • [Journal Article] Factors modulating bioavailability of quercetin-related flavonoids and2017

    • Author(s)
      Junji Terao
    • Journal Title

      Biochemical Pharmacology

      Volume: in press Pages: 15-23

    • DOI

      10.1016/j.bcp.2017.03.021

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 動物実験による食品機能成分の有効性評価とその問題点ーカロテノイドとフラボノイドについてー2017

    • Author(s)
      寺尾純二
    • Organizer
      日本栄養食糧学会2017年度大会
    • Related Report
      2017 Research-status Report
  • [Funded Workshop] 8th International conference on Polyphenols and Health2017

    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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