| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The usefulness of basophil activation was suggested in tomato allergen sensitization induced by the exposure to JCP and tomato allergy diagnosis, but no significant difference was obtained. JCP-specific IgE was significantly decreased 17 months after JCP-based subcutaneous allergen immunotherapy(SCIT). JCP-specific IgG4 increased significantly after 5 months SCIT. Peripheral blood basophil activation by JCP stimulation was significantly decreased in a dose-dependent manner, and Area under the Curve (AUC) of the activation was significantly decreased after 5 months SCIT. It was suggested that the previously considered immunological mechanism of allergen immunotherapy, which leads to remission after the induction of desensitization in the early stage, also applies to JCP-based SCIT.
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