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Tomato allergy: Mechanism from antigen sensitization to onset and cure

Research Project

Project/Area Number 16K00831
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionKanagawa Children's Medical Center (Clinical Research Institute) (2018-2019)
St. Marianna University School of Medicine (2017)
Fujita Health University (2016)

Principal Investigator

Inuo Chisato  地方独立行政法人神奈川県立病院機構神奈川県立こども医療センター(臨床研究所), 臨床研究所, 部長 (30586780)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords食物アレルギー / 果物アレルギー / トマトアレルギー / 末梢血好塩基球活性化
Outline of Final Research Achievements

The usefulness of basophil activation was suggested in tomato allergen sensitization induced by the exposure to JCP and tomato allergy diagnosis, but no significant difference was obtained. JCP-specific IgE was significantly decreased 17 months after JCP-based subcutaneous allergen immunotherapy(SCIT). JCP-specific IgG4 increased significantly after 5 months SCIT. Peripheral blood basophil activation by JCP stimulation was significantly decreased in a dose-dependent manner, and Area under the Curve (AUC) of the activation was significantly decreased after 5 months SCIT. It was suggested that the previously considered immunological mechanism of allergen immunotherapy, which leads to remission after the induction of desensitization in the early stage, also applies to JCP-based SCIT.

Academic Significance and Societal Importance of the Research Achievements

末梢血好塩基球活性化は発症早期から体内の免疫機構の変化を反映するため、早期診断、発症予防、治療効果の評価に利用できることが期待される。また、長期的にスギ花粉皮下注射免疫療法がスギ抗原に対する末梢血好塩基球活性化を低下させることから、治療により抗原交差性を有するトマト抗原に対する反応も低下させることが期待できる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (15 results)

All 2019 2018 2017

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (8 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Hyponatremia secondary to severe atopic dermatitis in early infancy2019

    • Author(s)
      Adachi M.,Takamasu T.,Inuo C.
    • Journal Title

      Pediatr Int

      Volume: 61 Issue: 6 Pages: 544-550

    • DOI

      10.1111/ped.13865

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 沐浴指導内容の変更による1ヵ月健診での皮膚症状有症率への影響2019

    • Author(s)
      吉岡 奈月,井上 瑶子,小島 隆浩,犬尾 千聡
    • Journal Title

      助産雑誌

      Volume: 73 Pages: 392-397

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【アレルギーを治そう!?免疫療法のいま?】<免疫療法をはじめる前に>食物アレルギー2019

    • Author(s)
      犬尾 千聡
    • Journal Title

      チャイルド ヘルス

      Volume: 22 Pages: 499-502

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Tolerability of partially and extensively hydrolysed milk formulas in children with cow's milk allergy.2019

    • Author(s)
      Inuo Chisato、Tanaka Kenichi、Nakajima Yoichi、Yamawaki Kazuo、 Matsubara T, Iwamoto H, Tsuge Ikuya、Urisu Atsuo、Kondo Yasuto
    • Journal Title

      Asia Pacific journal of clinical nutrition

      Volume: 28 Pages: 49-56

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term immunological effects of Japanese cedar pollen-based subcutaneous immunotherapy2018

    • Author(s)
      Inuo C, Ando H, Tanaka K, Nakajima Y, Tsuge I, Urisu A, Kondo Y.
    • Journal Title

      Allergology International

      Volume: 67 Issue: 3 Pages: 408-410

    • DOI

      10.1016/j.alit.2017.11.002

    • NAID

      130007420604

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral Immunotherapy Using Partially Hydrolyzed Formula for Cow’s Milk Protein Allergy: A Randomized, Controlled Trial2018

    • Author(s)
      Inuo Chisato、Tanaka Kenichi、Suzuki Satoko、Nakajima Yoichi、Yamawaki Kazuo、Tsuge Ikuya、Urisu Atsuo、Kondo Yasuto
    • Journal Title

      International Archives of Allergy and Immunology

      Volume: 177 Issue: 3 Pages: 259-268

    • DOI

      10.1159/000490804

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of serum IgE in peach-allergic patients with systemic reaction by using recombinant Pru p 7 (gibberellin-regulated protein)2018

    • Author(s)
      Mori Y.、Okazaki F.、Inuo C.、Yamaguchi Y.、Masuda S.、Sugiura S.、Fukuie T.、Nagao M.、Tsuge I.、Yosikawa T.、Yagami A.、Matsunaga K.、Fujisawa T.、Ito K.、Narita H.、Kondo Y.
    • Journal Title

      Allergologia et Immunopathologia

      Volume: 46 Issue: 5 Pages: 482-490

    • DOI

      10.1016/j.aller.2018.02.007

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] スギ花粉皮下注射免疫療法後にダニ特異的末梢血好塩基球活性化は低下する2019

    • Author(s)
      犬尾 千聡,安藤 仁志,田中 健一,中島 陽一,柘植 郁哉,宇理須 厚雄,近藤 康人
    • Organizer
      第68回日本アレルギー学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 鶏卵アレルギー児に対する極少量経口負荷試験の安全性の検討2019

    • Author(s)
      上原 健史,津曲 俊太郎,藤田 真弓,高増 哲也,犬尾 千聡
    • Organizer
      第56回日本小児アレルギー学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 花粉-食物アレルギー症候群に対するシラカバ花粉皮下免疫療法におけるアレルゲン投与量の検討2019

    • Author(s)
      津曲 俊太郎,藤田 真弓,高増 哲也,犬尾 千聡
    • Organizer
      第68回日本アレルギー学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ピーナッツ急速経口免疫療法後の維持期の摂取量と摂取間隔における特異的IgE値の変化2019

    • Author(s)
      藤田 真弓,津曲 俊太郎,高増 哲也,犬尾 千聡
    • Organizer
      第56回日本小児アレルギー学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 当科で施行したスギ皮下免疫療法におけるスギ特異的IgE値の変化の検討2019

    • Author(s)
      藤田 真弓,津曲 俊太郎,高増 哲也,犬尾 千聡
    • Organizer
      第68回日本アレルギー学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 全身麻酔手術を受ける気管支喘息患者の管理状況2019

    • Author(s)
      福田 淳奈,藤田 真弓,津曲 俊太郎,高増 哲也,犬尾 千聡
    • Organizer
      第357回日本小児科学会神奈川県地方会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Evaluation of the dose effect of birch pollen-based subcutaneous immunotherapy for apple allergy2019

    • Author(s)
      Tsumagari Shuntaro,Fujita Mayumi ,Takamasu Tetsuya,Inuo Chisato
    • Organizer
      KAAACI-KAPARD-WPAS-INTERASMA Joint Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] スギ皮下注射免疫療法5年治療後のスギアレルゲンの免疫学的変化2017

    • Author(s)
      犬尾千聡
    • Organizer
      第 36 回日本耳鼻咽喉科免疫アレルギー学会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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