Tomato allergy: Mechanism from antigen sensitization to onset and cure
| Project/Area Number |
16K00831
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Kanagawa Children's Medical Center (Clinical Research Institute) (2018-2019)
St. Marianna University School of Medicine (2017)
Fujita Health University (2016) |
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Principal Investigator |
Inuo Chisato 地方独立行政法人神奈川県立病院機構神奈川県立こども医療センター(臨床研究所), 臨床研究所, 部長 (30586780)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 食物アレルギー / 果物アレルギー / トマトアレルギー / 末梢血好塩基球活性化 |
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| Outline of Final Research Achievements |
The usefulness of basophil activation was suggested in tomato allergen sensitization induced by the exposure to JCP and tomato allergy diagnosis, but no significant difference was obtained. JCP-specific IgE was significantly decreased 17 months after JCP-based subcutaneous allergen immunotherapy(SCIT). JCP-specific IgG4 increased significantly after 5 months SCIT. Peripheral blood basophil activation by JCP stimulation was significantly decreased in a dose-dependent manner, and Area under the Curve (AUC) of the activation was significantly decreased after 5 months SCIT. It was suggested that the previously considered immunological mechanism of allergen immunotherapy, which leads to remission after the induction of desensitization in the early stage, also applies to JCP-based SCIT.
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| Academic Significance and Societal Importance of the Research Achievements |
末梢血好塩基球活性化は発症早期から体内の免疫機構の変化を反映するため、早期診断、発症予防、治療効果の評価に利用できることが期待される。また、長期的にスギ花粉皮下注射免疫療法がスギ抗原に対する末梢血好塩基球活性化を低下させることから、治療により抗原交差性を有するトマト抗原に対する反応も低下させることが期待できる。
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Report
(5 results)
Research Products
(15 results)
