Preventive effect of polyphenols in rugosa rose petals on arteriosclerosis

• Project/Area Number: 16K00843
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Kitami Institute of Technology
• Principal Investigator: Hirofumi Arai 北見工業大学, 工学部, 教授 (70295848)
• Co-Investigator(Kenkyū-buntansha): 福永 健治 関西大学, 化学生命工学部, 教授 (30278634)
• Research Collaborator: YAMAGISHI takashi
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: ハマナス / ポリフェノール / テリマグランジン / 活性酸素 / 酸化ストレス / 低密度リポタンパク質 / アテローム性動脈硬化症 / 動物実験 / 食品 / 抗酸化

Outline of Final Research Achievements

It has been suggested that low-density lipoprotein (LDL) oxidation by reactive oxygen species (ROS) and reactive nitrogen species (RNS), followed by scavenging by monocyte-derived macrophages under the arterial endothelium, leads to atherosclerosis. Objectives of this study are to investigate anti-atherogenic effects of polyphenols of rugosa rose petals, as a physiological function of them. Tellimagrandin I, a major polyphenol of rugosa rose petals, strongly suppressed lipid peroxidation and oxidative modification of protein in LDL oxidized by ROS and RNS. These results suggest that polyphenols of rugosa rose petals may prevent arteriosclerosis by reducing oxidative stress.

Academic Significance and Societal Importance of the Research Achievements

ハマナス花弁の主要ポリフェノールであるテリマグランジンⅠは、食品や生薬中に存在することが知られているが、その生理機能に関しては報告が少なかった。本研究では、ハマナス花弁ポリフェノールの新たな生理機能の一つとして抗酸化作用を介したアテローム性動脈硬化症の予防効果の解明を目指した。その成果として、ハマナス花弁ポリフェノールがアテローム性動脈硬化症の発症原因となる低密度リポタンパク質の酸化を強く抑制することが明らかになったことにより、その抗酸化作用を活かした機能性食品の開発に貢献できると考えられる。

Research Products

• [Presentation] Suppression of low-density lipoprotein oxidation by tellimagrandin I (2018)
  • Author(s): Arai, H., Sekimoto, S., Sukhbold, E., Hosomi, R., Fukunaga, K., Yamagishi, T., and Takasugi, M.
  • Organizer: The 21st International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants
  • Int'l Joint Research
• [Presentation] Effects of tellimagrandin I on oxidation of low-density lipoprotein (2017)
  • Author(s): Arai, H., Sekimoto, S., Mizuma, T., Saitoh, H., Sukhbold, E., Takasugi, M.
  • Organizer: International Conference on Polyphenols and Health
  • Int'l Joint Research