Suppressive mechanism of rice protein on kidney disease progression in obese diabetes by metabolome analysis
| Project/Area Number |
16K00855
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | University of Niigata Prefecture |
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Principal Investigator |
Watanabe Reiko 新潟県立大学, その他, 名誉教授 (70141348)
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| Research Collaborator |
KADOWAKI motoni
KUBOTA masatoshi
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 米胚乳タンパク質 / 肥満2型糖尿病 / 糖尿病性腎症 / 尿中代謝物質 / メタボローム解析 / ZDFラット / 米糠タンパク質 / 脂肪肝 / ＺＤＦラット |
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| Outline of Final Research Achievements |
In Zucker Diabetic Fatty rats, which are an animal model of obese type 2 diabetes mellitus, we have found that rice endosperm protein (REP) has preventive effects on obese diabetes, fatty liver and diabetic nephropathy. To clarify the functional mechanism of REP, the changes of urinary metabolite profiles were determined using CE-TOFMS. Eighty six metabolites in REP group were significantly changed compared with casein. Specifically, major alterations were found in metabolites from carnitine pathway, urea cycle, and tryptophan catabolism and large change was also found in hippuric acid.
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| Academic Significance and Societal Importance of the Research Achievements |
2型糖尿病は生活習慣病の最たる疾病で、かつ腎疾患や高血圧症との関連が密接である。また、肥満も多くの疾患の要因になっている。特に糖尿病性腎症の重症化は医療費高騰を招き、社会的重点課題である。腎疾患の食事療法では、病態ステージによりタンパク質制限が推奨されているが、タンパク質の「質の相違」は考慮されず、低タンパク米が利用されているのが現状である。それゆえ、本研究成果は新知見を提供することになる。また、米を中心とした伝統的食生活を栄養学的に再評価することになり、医療費軽減とともに米の消費拡大につながる。
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Beneficial effects of rice endosperm protein intake in Japanese men with risk factors for metabolic syndrome: a randomized, crossover clinical trial.2016
Author(s)
Hosojima M, Kaseda R, Kondo H, Fujii M, Kubota M, Watanabe R, Tanabe N, Kadowaki M, Suzuki Y, Saito A
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Journal Title
BMC Nutrition
Volume: 2
Issue: 1
Pages: 25-33
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Rice bran protein suppresses deteriolation of bone microstructure and strength in in obese type 2 diabetic rats2018
Author(s)
Masatoshi Kubota, Syogo Sugaki, Erika Komori, Reiko Watanabe, Hiroyuki Hashimoto, Yukikazu Harada, Michihiro Hosojima, Akihiro Sato, Shuichi Aoyagi, Shinobu Fujimura, Motoni Kadowaki
Organizer
The 3rd International Symposium on Rice Science in Global Health
Related Report
Int'l Joint Research
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