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Suppressive mechanism of rice protein on kidney disease progression in obese diabetes by metabolome analysis

Research Project

Project/Area Number 16K00855
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionUniversity of Niigata Prefecture

Principal Investigator

Watanabe Reiko  新潟県立大学, その他, 名誉教授 (70141348)

Research Collaborator KADOWAKI motoni  
KUBOTA masatoshi  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords米胚乳タンパク質 / 肥満2型糖尿病 / 糖尿病性腎症 / 尿中代謝物質 / メタボローム解析 / ZDFラット / 米糠タンパク質 / 脂肪肝 / ZDFラット
Outline of Final Research Achievements

In Zucker Diabetic Fatty rats, which are an animal model of obese type 2 diabetes mellitus, we have found that rice endosperm protein (REP) has preventive effects on obese diabetes, fatty liver and diabetic nephropathy. To clarify the functional mechanism of REP, the changes of urinary metabolite profiles were determined using CE-TOFMS. Eighty six metabolites in REP group were significantly changed compared with casein. Specifically, major alterations were found in metabolites from carnitine pathway, urea cycle, and tryptophan catabolism and large change was also found in hippuric acid.

Academic Significance and Societal Importance of the Research Achievements

2型糖尿病は生活習慣病の最たる疾病で、かつ腎疾患や高血圧症との関連が密接である。また、肥満も多くの疾患の要因になっている。特に糖尿病性腎症の重症化は医療費高騰を招き、社会的重点課題である。腎疾患の食事療法では、病態ステージによりタンパク質制限が推奨されているが、タンパク質の「質の相違」は考慮されず、低タンパク米が利用されているのが現状である。それゆえ、本研究成果は新知見を提供することになる。また、米を中心とした伝統的食生活を栄養学的に再評価することになり、医療費軽減とともに米の消費拡大につながる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (16 results)

All 2019 2018 2017 2016

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (12 results) (of which Int'l Joint Research: 7 results)

  • [Journal Article] Mini-Review; Physiological multifunctions of rice proteins of endosperm and bran2019

    • Author(s)
      Motoni Kadowaki, Masatoshi Kubota, Reiko Watanabe
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 印刷中

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Randomized, Double-Blind, Crossover Pilot Trial of Rice Endosperm Protein Supplementation in Maintenance Hemodialysis Patients2017

    • Author(s)
      Hosojima Michihiro、Shimada Hisaki、Obi Yoshitsugu、Kuwahara Shoji、Kaseda Ryohei、Kabasawa Hideyuki、Kondo Hazuki、Fujii Mikio、Watanabe Reiko、Suzuki Yoshiki、Kadowaki Motoni、Miyazaki Shigeru、Saito Akihiko
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 1-10

    • DOI

      10.1038/s41598-017-18340-8

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Beneficial effects of rice endosperm protein intake in Japanese men with risk factors for metabolic syndrome: a randomized, crossover clinical trial.2016

    • Author(s)
      Hosojima M, Kaseda R, Kondo H, Fujii M, Kubota M, Watanabe R, Tanabe N, Kadowaki M, Suzuki Y, Saito A
    • Journal Title

      BMC Nutrition

      Volume: 2 Issue: 1 Pages: 25-33

    • DOI

      10.1186/s40795-016-0065-7

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rice endosperm protein slows progression of fatty liver and diabetic nephropathy in Zucker diabetic fatty rats.2016

    • Author(s)
      Kubota M, Watanabe R, Yamaguchi M, Hosojima M, Saito A, Fujii M, Fujimura S, Kadowaki M
    • Journal Title

      Br J Nutr

      Volume: 116 Issue: 8 Pages: 1326-1335

    • DOI

      10.1017/s0007114516003512

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 米胚乳タンパク質摂取が2型糖尿病モデルラットの尿中代謝物プロファイルに与える影響2018

    • Author(s)
      久保田真敏,菅木省吾,渡邊令子,樋口裕樹,細島康宏,斎藤亮彦,藤村 忍,門脇基二
    • Organizer
      日本栄養・食糧学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Rice bran protein affects metabolome profile in obese type 2 diabetic rats2018

    • Author(s)
      Reiko Watanabe, Miki Yamaguchi, Masatoshi Kubota, Hiroyuki Hashimoto, Yukikazu Harada, Michihiro Hosojima, Akihiro Sato, Shinobu Fujimura, Motoni Kadowaki
    • Organizer
      The 3rd International Symposium on Rice Science in Global Health
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rice bran protein suppresses deteriolation of bone microstructure and strength in in obese type 2 diabetic rats2018

    • Author(s)
      Masatoshi Kubota, Syogo Sugaki, Erika Komori, Reiko Watanabe, Hiroyuki Hashimoto, Yukikazu Harada, Michihiro Hosojima, Akihiro Sato, Shuichi Aoyagi, Shinobu Fujimura, Motoni Kadowaki
    • Organizer
      The 3rd International Symposium on Rice Science in Global Health
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] New physiological functions of rice proteins of endosperm and bran2018

    • Author(s)
      Motoni Kadowaki
    • Organizer
      The 3rd International Symposium on Rice Science in Global Health
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 2型糖尿病モデルZDFラットの骨・ミネラル代謝異常に対する米糠タンパク質の有効性2017

    • Author(s)
      菅木省吾,久保田真敏,渡邊令子,橋本博之,原田幸和,細島康宏,斎藤亮彦,笹川一郎,藤村忍,門脇基二
    • Organizer
      日本農芸化学会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 米胚乳タンパク質が2型糖尿病モデルZDFラットのCKD-MBDに与える影響2017

    • Author(s)
      久保田真敏,菅木省吾,渡邊令子,細島康宏,斎藤亮彦,樋口裕樹,藤井幹夫,笹川一郎,藤村 忍,門脇基二
    • Organizer
      日本栄養・食糧学会
    • Related Report
      2017 Research-status Report
  • [Presentation] ステージ別による慢性腎臓病(CKD)患者のたんぱく質およびリン摂取量とその食品群の関連2017

    • Author(s)
      村松芳多子,渡邊令子,林 祐美,細島康宏,門脇基二,斎藤亮彦
    • Organizer
      日本栄養・食糧学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Beneficial effects of rice endosperm protein on chronic kidney disease-mineral and bone disorder (CKD-MBD) in Zucker diabetic fatty rats2017

    • Author(s)
      Watanabe R, Kubota M, Sugaki S, Hosojima M, Saito A, Fujii M, Sasagawa I, Fujimura S, Kadowaki M
    • Organizer
      21st International Congress of Nutrition
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Beneficial effect of rice endosperm protein on IgE production2017

    • Author(s)
      Kubota M, KamadaT, Hara T, Higuchi Y, Fujii M, Sato S, Fujimura S, Kadowaki M
    • Organizer
      21st International Congress of Nutrition
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Rice bran protein has beneficial effects on diabetes, fatty liver and diabetic nephropathy2016

    • Author(s)
      Masatoshi Kubota, Miki Yamaguchi, Reiko Watanabe, Hiroyuki Hashimoto, Yukikazu Harada, Michihiro Hosojima, Akihiko Saito, Shinobu Fujimura, Motoni Kadowaki
    • Organizer
      The 3rd International Conference on Rice Bran Oil
    • Place of Presentation
      東京大学伊藤国際学術研究センター(東京都文京区)
    • Year and Date
      2016-10-25
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Rice bran protein has beneficial effects on chronic kidney disease-mineral and bone disorder (CKD-MBD) in type 2 diabetic ZDF rats2016

    • Author(s)
      Syogo Sugaki, Erika Komori, Masatoshi Kubota, Reiko Watanabe, Hiroyuki Hashimoto, Yukikazu Harada, Michitoshi Hosojima, Akihiko Saito, Shinobu Fujimura, Motoni Kadowaki
    • Organizer
      The 3rd International Conference on Rice Bran Oil
    • Place of Presentation
      東京大学伊藤国際学術研究センター(東京都文京区)
    • Year and Date
      2016-10-25
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 米胚乳タンパク質の特性と糖尿病合併症に対する有効性2016

    • Author(s)
      久保田真敏,渡邊令子,熊谷武久,斎藤亮彦,門脇基二
    • Organizer
      日本栄養・食糧学会
    • Place of Presentation
      武庫川女子大学(兵庫県西宮市)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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