Elucidation of nutrition-gene interaction in diabetic patients using prospective cohort study

• Project/Area Number: 16K00861
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Kyushu University
• Principal Investigator: Fujii Hiroki 九州大学, 医学研究院, 共同研究員 (50623063)
• Co-Investigator(Kenkyū-buntansha): 岩瀬 正典 九州大学, 医学研究院, 共同研究員 (00203381)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 糖尿病 / コホート研究 / 遺伝子-環境相互作用 / ２型糖尿病 / SNP / 疫学研究 / 栄養素 / 栄養疫学

Outline of Final Research Achievements

In this study, we examined the effects of environmental and genetic factors on the development of type 2 diabetes. We enrolled 5131 diabetic patients (Fukuoka Diabetes Registry, 5 years follow-up rate 97%) attending diabetes centers in Fukuoka Prefecture and constructed genomic cohort database. In this study period, we reported about smoking, severe hypoglycemia, chronic kidney disease, cancer, fractures, foot ulcers, and gene-environment interactions in diabetic patients.

Academic Significance and Societal Importance of the Research Achievements

環境、遺伝因子、合併症発症状況などを統合したデータベースの作成を行った。人種差のある環境因子、遺伝因子両者の情報を統合した糖尿病患者のデータベースは我が国には報告がない。従来の研究では、環境因子を主として合併症予測を行っていたが、本研究の結果により、環境、遺伝両因子を考慮した合併症の高リスク群の同定が可能となる。得られた知見を元に、効率的な合併症予防が可能となり、個々の患者に合わせた効果的な介入を行うテーラーメイド医療の実現へ役立つ。

Research Products

• [Journal Article] Incidence of severe hypoglycemia and its association with serum adiponectin in Japanese patients with type 1 and insulin-treated type 2 diabetes: The Fukuoka Diabetes Registry (2020)
  • Author(s): Iwase M, Komorita Y, Fujii H, Ohkuma T, Ide H, Yoshinari M, Oku Y, Higashi T, Nakamura U, Kitazono T
  • Journal Title: J Diabetes Investig Volume: - Issue: 5 Pages: 1258-1264
  • DOI: 10.1111/jdi.13253
  • Peer Reviewed / Open Access
• [Journal Article] Both hypo- and hyperglycaemia are associated with increased fracture risk in Japanese people with type 2 diabetes: the Fukuoka Diabetes Registry (2020)
  • Author(s): Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Yoshinari M, Oku Y, Nakamura U, Kitazono T
  • Journal Title: Diabet Med Volume: 37 Issue: 5 Pages: 838-847
  • DOI: 10.1111/dme.14142
  • Peer Reviewed
• [Journal Article] Impact of hip fracture on all-cause mortality in Japanese patients with type 2 diabetes mellitus: The Fukuoka Diabetes Registry (2020)
  • Author(s): Komorita Y, Iwase M, Idewaki Y, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Yoshinari M, Murao-Kimura A, Oku Y, Nakamura U, Kitazono T
  • Journal Title: J Diabetes Investig Volume: 11 Issue: 1 Pages: 62-69
  • DOI: 10.1111/jdi.13076
  • Peer Reviewed
• [Journal Article] Prospective study of cancer in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry (2019)
  • Author(s): Iwase M, Fujii H, Idewaki Y, Nakamura U, Ohkuma T, Ide H, Komorita Y, Jodai-Kitamura T, Yoshinari M, Kitazono T
  • Journal Title: Diabetol Int Volume: 10 Issue: 4 Pages: 260-267
  • DOI: 10.1007/s13340-019-00390-0
  • NAID: 40022039935
  • Peer Reviewed
• [Journal Article] Impact of Body Weight Loss From Maximum Weight on Fragility Bone Fractures in Japanese Patients With Type 2 Diabetes: The Fukuoka Diabetes Registry. (2018)
  • Author(s): Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Sumi A, Yoshinari M, Nakamura U, Kang D, Kitazono T.
  • Journal Title: Diabetes Care. Volume: 41 Issue: 5 Pages: 1061-1067
  • DOI: 10.2337/dc17-2004
  • Peer Reviewed
• [Journal Article] Impact of age at menarche on obesity and glycemic control in Japanese patients with type 2 diabetes: Fukuoka Diabetes Registry (2018)
  • Author(s): Sumi A, Iwase M, Nakamura U, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Komorita Y, Yoshinari M, Kitazono T
  • Journal Title: J Diabetes Investig Volume: 9 Issue: 5 Pages: 1216-1223
  • DOI: 10.1111/jdi.12839
  • Peer Reviewed
• [Journal Article] The serum creatinine to cystatin C ratio predicts bone fracture in patients with type 2 diabetes: The Fukuoka Diabetes Registry (2018)
  • Author(s): Komorita Y, Iwase M, Fujii H, Ide H, Ohkuma T, Jodai-Kitamura T, Sumi A, Yoshinari M, Nakamura U, Kitazono T
  • Journal Title: Diabetes Res Clin Pract Volume: 146 Pages: 202-210
  • DOI: 10.1016/j.diabres.2018.10.021
  • Peer Reviewed
• [Journal Article] Incidence of diabetic foot ulcer in Japanese patients with type 2 diabetes mellitus: The Fukuoka diabetes registry (2018)
  • Author(s): Iwase M, Fujii H, Nakamura U, Ohkuma T, Ide H, Jodai-Kitamura T, Sumi A, Komorita Y, Yoshinari M, Kitazono T
  • Journal Title: Diabetes Res Clin Pract Volume: 137 Pages: 183-189
  • DOI: 10.1016/j.diabres.2018.01.020
  • Peer Reviewed
• [Journal Article] Serum adiponectin predicts fracture risk in individuals with type 2 diabetes: the Fukuoka Diabetes Registry (2017)
  • Author(s): Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Sumi A, Yoshinari M, Nakamura U, Kang D, Kitazono T
  • Journal Title: Diabetologia Volume: 10 Issue: 10 Pages: 1922-1930
  • DOI: 10.1007/s00125-017-4369-1
  • Peer Reviewed
• [Journal Article] The gene-treatment interaction of paraoxonase-1 gene polymorphism and statin therapy on insulin secretion in Japanese patients with type 2 diabetes: Fukuoka diabetes registry (2017)
  • Author(s): Sumi A, Nakamura U, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Komorita Y, Yoshinari M, Hirakawa Y, Hirano A, Kubo M, Kitazono T
  • Journal Title: BMC Med Genet Volume: 12 Issue: 1 Pages: 146-146
  • DOI: 10.1186/s12881-017-0509-1
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of cystatin C- and creatinine-based estimated glomerular filtration rates for predicting all-cause mortality in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry (2016)
  • Author(s): Ide H, Iwase M, Fujii H, Ohkuma T, Kaizu S, Jodai T, Kikuchi Y, Idewaki Y, Sumi A, Nakamura U, Kitazono T
  • Journal Title: Clin Exp Nephrol Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of smoking and its cessation on creatinine- and cystatin C-based estimated glomerular filtration rates and albuminuria in male patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry (2016)
  • Author(s): Ohkuma T, Nakamura U, Iwase M, Ide H, Fujii H, Jodai T, Kaizu S, Kikuchi Y, Idewaki Y, Sumi A, Hirakawa Y, Kitazono T
  • Journal Title: Hypertens Res Volume: 39 Issue: 10 Pages: 744-751
  • DOI: 10.1038/hr.2016.51
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 2型糖尿病患者におけるBMIの変動性と死亡の関係 (2019)
  • Author(s): 藤井裕樹
  • Organizer: 第62回糖尿病学会年次学術集会
• [Presentation] 2型糖尿病患者におけるHbA1cの変動性と死亡の関係 福岡県糖尿病患者データベース研究(Fukuoka Diabetes Registry) (2018)
  • Author(s): 藤井 裕樹, 岩瀬 正典, 中村 宇大, 大隈 俊明, 井手 均, 小森田 祐二, 吉成 匡人, 角 亜希子, 井手脇 康裕, 佐々木 伸浩, 布井 清秀, 五島 大祐, 野原 栄, 篠原 規恭, 南 昌江, 和田 美也, 横溝 由史, 菊池 正統, 野見山 理久, 中村 晋, 田代 憲司, 吉成 元孝, 市川 晃治郎, 北園 孝成
  • Organizer: 第61回日本糖尿病学会年次学術集会
• [Presentation] 2型糖尿病患者におけるBMIと死亡の関連 福岡県糖尿病患者データベース研究(Fukuoka Diabetes Registry) (2017)
  • Author(s): 藤井 裕樹, 岩瀬 正典, 中村 宇大, 大隈 俊明, 井手 均, 北村 環, 小森田 祐二, 吉成 匡人, 角 亜希子, 井手脇 康裕, 筒 信隆, 布井 清秀, 五島 大祐, 野原 栄, 篠原 規恭, 南 昌江, 和田 美也, 横溝 由史, 菊池 正統, 野見山 理久, 中村 晋, 田代 憲司, 吉成 元孝, 市川 晃治郎, 平川 洋一郎, 北園 孝成
  • Organizer: 第60回日本糖尿病学会年次学術集会
• [Presentation] マグネシウム摂取が2型糖尿病患者の糖尿病合併症に与える影響: 福岡県糖尿病患者データベース研究(FDR9) (2016)
  • Author(s): 藤井裕樹
  • Organizer: 第59回日本糖尿病学会年次学術集会
  • Place of Presentation: 京都
  • Year and Date: 2016-05-19
• [Presentation] 2型糖尿病患者において睡眠時間は網膜症リスクと関連する: Fukuoka Diabetes Registry (2016)
  • Author(s): 大隈俊明
  • Organizer: 第59回日本糖尿病学会年次学術集会
  • Place of Presentation: 京都
  • Year and Date: 2016-05-19
• [Presentation] 2 型糖尿病患者における低炭水化物摂取は総死亡リスクに影響しない Fukuoka Diabetes Registry (2016)
  • Author(s): 井手均
  • Organizer: 第59回日本糖尿病学会年次学術集会
  • Place of Presentation: 京都
  • Year and Date: 2016-05-19
• [Remarks] 福岡県糖尿病患者データベース研究
  • URL: http://www.diabetes.med.kyushu-u.ac.jp/fdr/