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Effects of folic acid fortified foods on blood folate status in genetic polymorphism and eating habits

Research Project

Project/Area Number 16K00865
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionShukutoku University

Principal Investigator

Fukushima Mami  淑徳大学, 看護栄養学部, 准教授 (30286885)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords葉酸 / テーラーメイド栄養 / ホモシステイン / 葉酸強化食品 / 遺伝子多型 / 赤血球葉酸 / テーラーメイド栄養指導 / folate / folic aid / folic acid / 栄養学
Outline of Final Research Achievements

The folate intake from fortified foods was about 195 μg/day DFE (dietary folate equivalents) in the health promotion program designated the “Sakado Folate Project”, which aimed to achieve personalized nutritional intervention based on the MTHFR C677T genotype for the prevention of various diseases, and which was shown to be sufficient to keep the reference value of serum total homocysteine. Vitamin B2 was also suggested to be a factor that decreases homocysteine, meanwhile saturated fatty acid might be a factor to increase the homocysteine level. There were no significant increases in red blood cell folate levels at 6 months after the onset of this intervention in all MTHFR C677T genotypes. The fortified rice was used more frequency for fortified food. A tendency that meal is neglected was not observed.

Academic Significance and Societal Importance of the Research Achievements

穀類への葉酸強化政策は、すでに世界80か国以上で実施されており、胎児の神経管閉鎖障害(NTDs)発症率の低下や、脳卒中による死亡率の低下、ある種のがんや認知症予防に対して効果をあげている。しかし我が国では葉酸強化は実施されておらず、葉酸推奨量は240μg/日と欧米諸国の400μgより低い。本研究では、葉酸栄養状態を良好に保つための葉酸摂取を400μgとした栄養介入において、葉酸強化食品から葉酸約200μg補充できることを示した。食事からの摂取量とあわせて目標に達する量であり、耐容上限量を超えることもない。今後の葉酸強化食品の普及に役立つものと思われる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2019 2018 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Book (1 results)

  • [Journal Article] 葉酸2019

    • Author(s)
      平岡真実
    • Journal Title

      日本食品安全協会会誌

      Volume: 14 Pages: 192-197

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Medical cost savings in Sakado City and worldwide achieved by preventing disease by folic acid fortification2017

    • Author(s)
      Kagawa Yasuo、Hiraoka Mami、Kageyama Mitsuyo、Kontai Yoshiko、Yurimoto Mayumi、Nishijima Chiharu、Sakamoto Kaori
    • Journal Title

      Congenital Anomalies

      Volume: 57 Issue: 5 Pages: 157-165

    • DOI

      10.1111/cga.12215

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic polymorphisms and folate status2017

    • Author(s)
      Hiraoka Mami、Kagawa Yasuo
    • Journal Title

      Congenital Anomalies

      Volume: 57 Issue: 5 Pages: 142-149

    • DOI

      10.1111/cga.12232

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 葉酸不足は母子健康だけの問題ではない2019

    • Author(s)
      平岡真実
    • Organizer
      第66回 日本栄養改善学会学術総会 共催シンポジウム4「ビタミン不足・欠乏の再考」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 遺伝子多型別テーラーメイド栄養指導による血中葉酸およびホモシステイン濃度改善に及ぼす食品摂取状況の検討2018

    • Author(s)
      平岡真実,坂本香織,金胎芳子,影山光代,百合本真弓,西島千陽,香川靖雄
    • Organizer
      第72回日本栄養・食糧学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] さかど葉酸プロジェクトにおけるMTHFR遺伝子 C677T 多型別テーラーメイド栄養指導と葉酸強化食品の使用2017

    • Author(s)
      西島千陽、坂本香織、平岡真実、影山光代、金胎芳子、百合本真弓、堀江修一、香川靖雄
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Reduction of homocysteine in persons with genetic polymorphism using folic acid fortified rice2017

    • Author(s)
      Chiharu Nishijima,Mami Hiraoka, Kaori Sakamoto, Mitsuyo Kageyama, Yoshiko Kontai, Mayumi Yurimoto and Yasuo Kagawa
    • Organizer
      49th Conference of the Asia-Pacific Academic Consortium for Public Health
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 遺伝子多型に基づく栄養指導とその実践2017

    • Author(s)
      平岡真実
    • Organizer
      第39回日本臨床栄養学会総会・第38回日本臨床栄養協会総会 第15回大連合大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] The effects of personalized nutrition intervention in folate status with MTHFR C677T genotype notification2016

    • Author(s)
      Mami Hiraoka, Kaori Sakamoto, Mitsuyo Kageyama, Yoshiko Kontai, Mayumi Yurimoto, Chiharu Nishijima and Yasuo Kagawa
    • Organizer
      The 48th Asia-Pacific Academic Consortium for Public Health Conference
    • Place of Presentation
      東京(帝京大学)
    • Year and Date
      2016-09-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 遺伝子多型と葉酸の栄養2016

    • Author(s)
      平岡真実
    • Organizer
      第56回日本先天異常学会学術集会
    • Place of Presentation
      姫路(姫路商工会議所)
    • Year and Date
      2016-07-30
    • Related Report
      2016 Research-status Report
    • Invited
  • [Book] Nutritional Guidance in Sakado Folate Project, B Group Vitamins - Current Uses and Perspectives2018

    • Author(s)
      Mayumi Yurimoto, Mami Hiraoka, Mitsuyo Kageyama, Yoshiko Kontai, Chiharu Nishijima, Kaori Sakamoto and Yasuo Kagawa
    • Publisher
      IntechOpen
    • ISBN
      9781789239904
    • Related Report
      2018 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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