Effect of dietary fatty acids on the change of myocardial fatty acids metabolism by ischemic heart disease and establishment of approproate diet program for the prevention of cardiac remodeling

• Project/Area Number: 16K00869
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Juntendo University
• Principal Investigator: Hiki Makoto 順天堂大学, 医学部, 准教授 (70643691)
• Co-Investigator(Kenkyū-buntansha): 宮崎 哲朗 順天堂大学, 医学部, 准教授 (30600473)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 1H-MRS法 / 心筋内中性脂肪 / 脂肪酸 / ミトコンドリア代謝 / 虚血性心疾患 / 心血管疾患 / 心筋脂肪酸代謝 / MRS法 / 心筋リモデリング / 食事運動療法 / 臨床栄養学 / 循環器学

Outline of Final Research Achievements

Although the main aim of this study was to evaluate myocardial triglyceride levels using MRS methods in patients with ischemic heart disease (IHD), myocardial triglyceride levels did not differ before and after the treatment for IHD. One of the possible reasons is the difficulty of measurement by thinning of infarcted myocardium.
On the other hand, we reported that significant lower myocardial triglyceride levels in patients with hypertrophic cardiomyopathy compared to those with hypertensive heart disease, suggesting different fatty acids metabolism between these two diseases. We also reported that several fatty acids, carnitine, and coenzyme Q10 (mitochondrial metabolism related substances) were associated with the prognosis of patients with various cardiovascular diseases.
Furthermore, important interactions between oxidative stress, mitochondrial dysfunction, and muscle wasting were demonstrated using aging, myocardial infarction model and Nox4-KO mice, respectively.

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的特色は脂肪酸バランスと心筋脂肪酸代謝という視点からの検証であること、心筋内中性脂肪量という新たな手法により効果的な心筋脂肪酸代謝への介入を開発する事の二点である。
心血管疾患は脂肪酸代謝と関連するが、血中の脂肪酸代謝指標と心筋内脂肪酸代謝の関連に着目した研究は極めて少なく、国内外でも我々のグループが先行している。また虚血性心疾患を含む種々の心血管疾患に対し、MRS法を用いて心筋内中性脂肪量を測定することにより得られた知見は、心疾患予防に有効な新たな食事プログラムや脂肪酸の摂取方法の開発に繋がり、国民の健康維持増進、国民医療に貢献できる研究であると考えられる。

Research Products

• [Journal Article] Usefulness of Cardiac Magnetic Resonance in the Diagnosis of Löffler Endocarditis Secondary to Eosinophilic Granulomatosis with Polyangiitis (2019)
  • Author(s): Kurokawa Kana、Sai Eiryu、Hayashi Eri、Minowa Kentaro、Sugano Koji、Yoshihara Takuma、Miyazaki Tadashi、Hiki Makoto、Yokoyama Takayuki、Suzuki Masaru、Miyauchi Katsumi
  • Journal Title: Internal Medicine Volume: 58 Issue: 2 Pages: 239-242
  • DOI: 10.2169/internalmedicine.1303-18
  • NAID: 130007579724
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2019-01-15
  • Peer Reviewed / Open Access
• [Journal Article] Adjustment of CT-fractional flow reserve based on fluid-structure interaction underestimation to minimize 1-year cardiac events (2019)
  • Author(s): Etsuro Kato, Shinichiro Fujimoto, Kanako K. Kumamaru, Yuko O. Kawaguchi, Tomotaka Dohi, Chihiro Aoshima, Yuki Kamo, Kazuhisa Takamura, Yoshiteru Kato, Makoto Hiki, Iwao Okai, Shinya Okazaki, Shigeki Aoki, Hiroyuki Daida
  • Journal Title: Heart and Vessels Volume: 35 Issue: 2 Pages: 162-169
  • DOI: 10.1007/s00380-019-01480-4
  • Peer Reviewed / Open Access
• [Journal Article] The predictive factors affecting false positive in on-site operated CT-fractional flow reserve based on fluid and structural interaction (2019)
  • Author(s): Kawaguchi Yuko O.、Fujimoto Shinichiro、Kumamaru Kanako K.、Kato Etsuro、Dohi Tomotaka、Takamura Kazuhisa、Aoshima Chihiro、Kamo Yuki、Kato Yoshiteru、Hiki Makoto、Okai Iwao、Okazaki Shinya、Aoki Shigeki、Daida Hiroyuki
  • Journal Title: IJC Heart & Vasculature Volume: 23 Pages: 100372-100372
  • DOI: 10.1016/j.ijcha.2019.100372
  • Peer Reviewed / Open Access
• [Journal Article] The usefulness of low radiation dose subtraction coronary computed tomography angiography for patients with calcification using 320-row area detector CT (2019)
  • Author(s): Takamura Kazuhisa、Fujimoto Shinichiro、Kawaguchi Yuko、Kato Etsuro、Aoshima Chihiro、Hiki Makoto、Kumamaru Kanako K.、Daida Hiroyuki
  • Journal Title: Journal of Cardiology Volume: 73 Issue: 1 Pages: 58-64
  • DOI: 10.1016/j.jjcc.2018.05.015
  • Peer Reviewed / Open Access
• [Journal Article] Promotion of oxidative stress is associated with mitochondrial dysfunction and muscle atrophy in aging mice (2019)
  • Author(s): Kadoguchi Tomoyasu、Shimada Kazunori、Miyazaki Tetsuro、Kitamura Kenichi、Kunimoto Mitsuhiro、Aikawa Tatsuro、Sugita Yurina、Ouchi Shohei、Shiozawa Tomoyuki、Yokoyama‐Nishitani Miho、Fukao Kosuke、Miyosawa Katsutoshi、Isoda Kikuo、Daida Hiroyuki
  • Journal Title: Geriatrics & Gerontology International Volume: 20 Issue: 1 Pages: 78-84
  • DOI: 10.1111/ggi.13818
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between the Kihon Checklist and the clinical parameters in patients who participated in cardiac rehabilitation (2019)
  • Author(s): Kunimoto Mitsuhiro、Shimada Kazunori、Yokoyama Miho、Matsubara Tomomi、Aikawa Tatsuro、Ouchi Shohei、Shimizu Megumi、Fukao Kosuke、Miyazaki Tetsuro、Kadoguchi Tomoyasu、Fujiwara Kei、Honzawa Akio、Yamada Miki、Shimada Akie、Yamamoto Taira、Amano Atsushi、Daida Hiroyuki
  • Journal Title: Geriatrics & Gerontology International Volume: 19 Issue: 4 Pages: 287-292
  • DOI: 10.1111/ggi.13617
  • Peer Reviewed / Open Access
• [Journal Article] Clinical significance of transluminal attenuation gradient in 320-row area detector coronary CT angiography (2018)
  • Author(s): Kato Etsuro、Fujimoto Shinichiro、Takamura Kazuhisa、Kawaguchi Yuko、Aoshima Chihiro、Hiki Makoto、Kumamaru Kanako K.、Daida Hiroyuki
  • Journal Title: Heart and Vessels Volume: 33 Issue: 5 Pages: 462-469
  • DOI: 10.1007/s00380-017-1081-5
  • Peer Reviewed / Open Access
• [Journal Article] Diagnostic performance of on-site computed CT-fractional flow reserve based on fluid structure interactions: comparison with invasive fractional flow reserve and instantaneous wave-free ratio (2018)
  • Author(s): Fujimoto Shinichiro、Kawasaki Tomonori、Kumamaru Kanako K、Kawaguchi Yuko、Dohi Tomotaka、Okonogi Taichi、Ri Keiken、Yamada Sou、Takamura Kazuhisa、Kato Etsuro、Kato Yoshiteru、Hiki Makoto、Okazaki Shinya、Aoki Shigeki、Mitsouras Dimitris、Rybicki Frank J、Daida Hiroyuki
  • Journal Title: European Heart Journal - Cardiovascular Imaging Volume: 20 Issue: 3 Pages: 343-352
  • DOI: 10.1093/ehjci/jey104
  • Peer Reviewed / Open Access
• [Journal Article] Possible Role of NADPH Oxidase 4 in Angiotensin II-Induced Muscle Wasting in Mice (2018)
  • Author(s): Kadoguchi Tomoyasu、Shimada Kazunori、Koide Hiroshi、Miyazaki Tetsuro、Shiozawa Tomoyuki、Takahashi Shuhei、Aikawa Tatsuro、Ouchi Shohei、Kitamura Kenichi、Sugita Yurina、Hamad Al Shahi、Kunimoto Mitsuhiro、Sato-Okabayashi Yayoi、Akita Koji、Isoda Kikuo、Daida Hiroyuki
  • Journal Title: Frontiers in Physiology Volume: 9 Pages: 1-9
  • DOI: 10.3389/fphys.2018.00340
  • Peer Reviewed / Open Access
• [Journal Article] Correlation of Nutritional Indices on Admission to the Coronary Intensive Care Unit with the Development of Delirium (2018)
  • Author(s): Sugita Yurina、Miyazaki Tetsuro、Shimada Kazunori、Shimizu Megumi、Kunimoto Mitsuhiro、Ouchi Shohei、Aikawa Tatsuro、Kadoguchi Tomoyasu、Kawaguchi Yuko、Shiozawa Tomoyuki、Takasu Kiyoshi、Hiki Masaru、Takahashi Shuhei、Sumiyoshi Katsuhiko、Iwata Hiroshi、Daida Hiroyuki
  • Journal Title: Nutrients Volume: 10 Issue: 11 Pages: 1712-1712
  • DOI: 10.3390/nu10111712
  • Peer Reviewed / Open Access
• [Journal Article] Chest X-Ray Revealed a Slowly Progressive Giant Right Coronary Artery Aneurysm in an Asymptomatic Patient (2018)
  • Author(s): Hiki Masaru、Iwata Hiroshi、Kawaguchi Yuko、Takamura Kazuhisa、Hiki Makoto、Miyazaki Tetsuro、Fujimoto Shinichiro、Amano Atsushi、Daida Hiroyuki
  • Journal Title: Cardiology Volume: 139 Issue: 4 Pages: 231-233
  • DOI: 10.1159/000486950
  • Peer Reviewed
• [Journal Article] Thrombolytic Therapy and Aspiration of Clots were Effective in the Removal of a Transient Inferior Vena Cava (IVC) Filter that Captured a Large Thrombus (2017)
  • Author(s): Takahashi N, Isoda K, Hiki M, Fujimoto S, Daida H
  • Journal Title: Internal Medicine Volume: 56 Issue: 11 Pages: 1369-1373
  • DOI: 10.2169/internalmedicine.56.8175
  • NAID: 130006857216
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Incremental Prognostic Value of Coronary Computed Tomography Angiography: High-Risk Plaque Characteristics in Asymptomatic Patients (2017)
  • Author(s): Takamura K, Fujimoto S, Kondo T, Hiki M, Kawaguchi Y, Kato E, Daida H
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 11 Pages: 1174-1185
  • DOI: 10.5551/jat.39115
  • NAID: 130006191600
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Submillisievert imaging protocol using full reconstruction and advanced patient motion correction in 320-row area detector coronary CT angiography (2017)
  • Author(s): Kawaguchi Yuko、Fujimoto Shinichiro、Takamura Kazuhisa、Kato Etsuro、Suda Shoko、Matsumori Rie、Hiki Makoto、Kumamaru Kanako K.、Daida Hiroyuki
  • Journal Title: The International Journal of Cardiovascular Imaging Volume: 34 Issue: 3 Pages: 465-474
  • DOI: 10.1007/s10554-017-1237-5
  • Peer Reviewed
• [Journal Article] Myocardial triglyceride content in patients with left ventricular hypertrophy: Comparison between hypertensive heart disease and hypertrophic cardiomyopathy. (2017)
  • Author(s): Sai E, Shimada K, Yokoyama T, Hiki M, Sato S, Hamasaki N, Maruyama M, Morimoto R, Miyazaki T, Fujimoto S, Tamura Y, Aoki S, Watada H, Kawamori R, Daida H.
  • Journal Title: Heart Vessels Volume: 32 Issue: 2 Pages: 166-174
  • DOI: 10.1007/s00380-016-0844-8
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Incremental prognostic value of coronary computed tomographic angiography high-risk plaque characteristics in newly symptomatic patients (2016)
  • Author(s): Fujimoto S, Kondo T, Takamura K, Baber U, Shinozaki T, Nishizaki Y, Kawaguchi Y, Matsumori R, Hiki M, Miyauchi K, Daida H, Hecht H, Stone GW, Narula J
  • Journal Title: J Cardiol Volume: in press Issue: 6 Pages: 538-544
  • DOI: 10.1016/j.jjcc.2015.07.018
  • Peer Reviewed / Open Access
• [Journal Article] Incremental predictive value for obstructive coronary artery disease by combination of Duke Clinical Score and Agatston score. (2016)
  • Author(s): Takamura K, Kondo T, Fujimoto S, Hiki M, Matsumori R, Kawaguchi Y, Amanuma M, Takase S, Daida H
  • Journal Title: Eur Heart J Cardiovasc Imaging. Volume: 17 Issue: 5 Pages: 550-556
  • DOI: 10.1093/ehjci/jev233
  • Peer Reviewed / Open Access
• [Journal Article] Low and exacerbated levels of 1,5-anhydroglucitol are associated with cardiovascular events in patients after first-time elective percutaneous coronary intervention (2016)
  • Author(s): Takahashi S, Shimada K, Miyauchi K, Miyazaki T, Sai E, Ogita M, Tsuboi S, Tamura H, Okazaki S, Shiozawa T, Ouchi S, Aikawa T, Kadoguchi T, Al Shahi H, Yoshihara T, Hiki M, Isoda K, Daida H
  • Journal Title: Cardiovasc Diabetol Volume: 15 Issue: 1 Pages: 145-145
  • DOI: 10.1186/s12933-016-0459-5
  • Peer Reviewed / Open Access
• [Journal Article] Low circulating coenzyme Q10 during acute phase is associated with inflammation, malnutrition, and in-hospital mortality in patients admitted to the coronary care unit (2016)
  • Author(s): Shimizu M, Miyazaki T, Takagi A, Sugita Y, Yatsu S, Murata A, Kato T, Suda S, Ouchi S, Aikawa T, Hiki M, Takahashi S, Hiki M, Hayashi H, Kasai T, Shimada K, Miyauchi K, Daida H
  • Journal Title: Heart Vessels Volume: 印刷中 Issue: 6 Pages: 668-673
  • DOI: 10.1007/s00380-016-0923-x
  • Peer Reviewed / Open Access
• [Presentation] Myocardial triglyceride content and late gadolinium enhancement in patients with hypertrophic cardiomyopathy: Comparison between asymmetric and concentric hypertrophy (2019)
  • Author(s): Sai E, Shimada K, Yokoyama T, Hiki M, Aikawa T, Aoshima C, Kawaguchi Y, Miyazaki T, Fujimoto S, Aoki S, Daida H
  • Organizer: European Association of Cardiovascular Imaging 2019
  • Int'l Joint Research
• [Presentation] Associations between ectopic fat acc: umulations and cardio-metabolic factors in apparently healthy subjects: assessed by 1H-magnetic resonance spectroscopy in myocardium, liver, and skeletal muscles (2019)
  • Author(s): Sai E, Shimada K, Yokoyama T, Hiki M, Aikawa T, Ouchi S, Aoshima C, Kawaguchi Y, Miyazaki T, Fujimoto S, Tamura Y, Aoki S, Watada H, Kawamori R, Daida H
  • Organizer: European Association of Cardiovascular Imaging 2019
  • Int'l Joint Research
• [Presentation] Voluntary exercise associated with myokine production ameliorates cardiac remodeling and inflammation in a myocardial infarction mouse model (2019)
  • Author(s): Kadoguchi T, Shimada K, Hamad A, Aikawa, T, Ouchi S, Kitamura K, Kunimoto M, Fukao K, Yokoyama M, Sugita Y, Shiozawa T, Matsushita S, Miyazaki T, Isoda K, Daida H
  • Organizer: European Society of Cardiology 2019
  • Int'l Joint Research
• [Presentation] Prognostic Impact of Peak Oxygen Uptake and Heart Rate Reserve in Patients After Off-pump Coronary Artery Bypass Grafting (2019)
  • Author(s): Abulimiti A, Shimada K, Yokoyama M, Kunimoto M, Matsubara T, Fujiwara K, Aikawa T, Ouchi S, Shimizu M, Fukao K, Kadoguchi T, Miyazaki T, Shimada A, Yamamoto T, Takahashi T, Fujiwara T, Amano A, Daida H
  • Organizer: American Heart Association Scientific Session 2019
  • Int'l Joint Research
• [Presentation] 流体構造物相互作用に基づき局所的に算出したCT冠血流予備量比の診断能 (2018)
  • Author(s): 川口 裕子, 藤本 進一郎, 川崎 友裕, 隈丸 加奈子, 土肥 智貴, 小此木 太一, 加藤 悦郎, 青島 千紘, 高村 和久, 華藤 芳輝, 比企 誠, 代田 浩之
  • Organizer: 日本循環器学会学術集会
• [Presentation] Sai E, Shimada K, Aikawa T, Yokohama T, Hiki M, Ouchi S, Kawaguchi Y, Miyazaki T, Fujimoto S, Aoki S, Daida H (2018)
  • Author(s): Myocardial triglyceride content and cardiac function in patients with left ventricular hypertrophy
  • Organizer: CMR 2018
• [Presentation] Angiotensin II-dependent activation of NADPH oxidase 4 contributes to muscle wasting in mice via downregulation of NF-E2-related factor 2 (2018)
  • Author(s): Kadoguchi T, Shimada K, Miyazaki T, Aikawa T, Ouchi S, Kitamura K, Kunimoto M, Sugita Y, Shiozawa T, Isoda K, Daida H
  • Organizer: European Society of Cardiology 2018
• [Presentation] Low serum vitamin D levels are associated with polyunsaturated fatty acids, inflammation and long-term mortality in patients with acute cardiovascular disease (2018)
  • Author(s): Aikawa T, Miyazaki T, Shimada K, Sugita Y, Kitamura K, Kunimoto M, Shimizu M, Ouchi S, Shiozawa T, Kadoguchi T, Hiki M, Takahashi S, Daida H
  • Organizer: European Society of Cardiology 2018
• [Presentation] Malnutrition and low omega 6 PUFA levels on admission were associated with the development of delirium in patients with acute cardiovascular disease admitted to coronary care unit (2018)
  • Author(s): Sugita Y, Miyazaki T, Shimizu M, Kunimoto M, Aikawa T, Ouchi S, Kadoguchi T, Kawaguchi Y, Shiozawa T, Takahashi K, Hiki M, Yokoyama M, Iwata Y, Shimada K, Daida H
  • Organizer: European Society of Cardiology 2018
• [Presentation] Angiotensin II誘発性筋肉消耗はNF-E2 related factor 2を介したNADPH oxidase 4由来酸化ストレスにより制御される (2018)
  • Author(s): 門口智泰, 島田和典, 宮崎哲朗, 塩澤知之, 高橋秀平, 相川達郎, 大内翔平, 喜多村健一, 杉田有里那, 國本充洋, 佐藤弥生, 磯田菊生, 代田浩之
  • Organizer: 日本循環器学会学術集会
• [Presentation] Myocardial triglyceride content and cardiac function in patients with left ventricular hypertrophy: comparison between severe aortic valve stenosis, hypertensive heart disease, and hypertrophic cardiomyopathy (2018)
  • Author(s): Eiryu Sai, Kazunori Shimada, Tatsuro Aikawa, Takayuki Yokoyama, Hiki Makoto, Shohei Ouchi, Yuko Kawaguchi, Tetsuro Miyazaki, Shinichiro Fujimoto, Shigeki Aoki, Hiroyuki Daida
  • Organizer: CMR 2018
  • Int'l Joint Research
• [Presentation] Usefulness of a Novel Plaque Analysis Software Using a Labeling Method in Low-tube Voltage Protoco (2018)
  • Author(s): Takamura K, Fujimoto S, Kato E, Kawaguchi Y, Aoshima C, Hiki M, Kumamaru K, Daida H
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] The Predictive Factors Affecting False Positive in On-Site Operated CT-Fractional Flow Reserve Based on Fluid and Structural Interaction (2018)
  • Author(s): Kato E, Fujimoto S, Takamura K, Kawaguchi Y, Hiki M, Aoshima C, Kumamaru K, Daida H
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] Diagnostic Performance of Locally Computed CT-Fractional Flow Reserve Based on Fluid Structure Interactions (2018)
  • Author(s): 川口裕子、藤本進一郎、川﨑友裕、隈丸加奈子、 土肥智貴、小此木太一、加藤悦郎、青島千紘、 高村和久、華藤芳輝、比企誠、代田浩之
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] Diagnostic Accuracy of On-Site Operated Novel CT-Fractional Flow Reserve Based on Structural and Fluid Analysis. (2017)
  • Author(s): Kawaguch Y, Fujimoto S, Kumamaru K, Dohi T, Ri K, Yamada S, Takimura K, Katou E, Katoh Y, Hiki M, Tamura H, Okazaki S, Isoda K, Daida H
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂他 (金沢)
  • Year and Date: 2017-03-17
• [Presentation] Usefulness of Novel Plaque Characteristics Analysis Software Employing the Labeling Method in Autopsy Cases. (2017)
  • Author(s): Takamura K, Fujimoto S, Katou E, Kawaguchi Y, Hiki M, Kumamaru K, Daida H
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂他 (金沢)
  • Year and Date: 2017-03-17
• [Presentation] Exercise Training Ameliorates Cardiac Inflammation and Improves Left Ventricular Function after Myocardial Infarction in a Mouse Model. (2017)
  • Author(s): Al Shahi H, Shimada K, Kadoguchi T, Akita K, Shiozawa T, Takahashi S, Aikawa T, Ouchi S, Sato Y,Matsushita S, Isoda K, Miyazaki T, Daida H
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂他 (金沢)
  • Year and Date: 2017-03-17
• [Presentation] Usefulness of Measuring Infarct Size for Predicting Post-infarct Left Ventricular Remodeling Using Cardiac Magnetic Resonance (2017)
  • Author(s): Tatsuro Aikawa, Takayuki Yokoyama, Makoto Hiki, Eiryu Sai, Yuko Kawaguchi, Shohei, Ouchi, Kazuhisa Takamura, Shinichiro Fujimoto, Tetsuro Miyazaki, Kazunori Shimada, Hiroyuki Daida
  • Organizer: Euro EMR
  • Int'l Joint Research
• [Presentation] 320列冠動脈CTによる1回転撮像から解析したTransluminal attenuation gradient(TAG)の意義 (2016)
  • Author(s): 加藤 悦郎, 藤本 進一郎, 高村 和久, 川口 裕子, 青島 千紘, 比企 誠, 隈丸 加奈子, 代田 浩之
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム (東京)
  • Year and Date: 2016-09-23
• [Presentation] The usefulness of low radiation dose subtraction coronary CT angiography for patients with calcification using 320 ADCT (2016)
  • Author(s): 高村 和久, 藤本 進一郎, 比企 誠, 川口 裕子, 加藤 悦郎, 青島 千紘, 隈丸 加奈子, 代田 浩之
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム (東京)
  • Year and Date: 2016-09-23
• [Presentation] Development of Comprehensive Plaque Evaluation by Coronary CT Angiography (2016)
  • Author(s): 藤本 進一郎, 高村 和久, 川口 裕子, 加藤 悦郎, 比企 誠, 土肥 智貴, 隈丸 加奈子, 代田 浩之
  • Organizer: 第48回日本動脈硬化学会総会
  • Place of Presentation: 京王プラザホテル (東京)
  • Year and Date: 2016-07-14