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Production of functional foods with high sensory properties by using flavor precursor of shiitake mushrooms

Research Project

Project/Area Number 16K00874
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionNihon University

Principal Investigator

KUMAGAI Hitomi  日本大学, 生物資源科学部, 教授 (20225220)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsシイタケフレーバー前駆体 / レンチニン酸 / 血中エタノール濃度上昇抑制 / エタノール吸収抑制 / エタノール代謝促進 / 血中アルコール濃度上昇抑制 / アルコール代謝促進 / アルコール吸収抑制 / 原木栽培 / 菌床栽培 / 加熱調理法 / デスグルタミルレンチニン酸 / γ-グルタミルトランスフェラーゼ / デスグルタミンルレンチニン酸 / レンチオニン / 肝障害抑制
Outline of Final Research Achievements

The method to evaluate the amount of lentinic acid, a flavor precursor of shiitake mushrooms, was established. Then, the amount of lentinic acid in shiitake mushrooms of different species, cultivation method, and processing mushrooms was compared. In addition, the suppressive effect of shiitake extract with high lentinic-acid content on the elevation of ethanol concentration in blood was examined. The orally-administered shiitake extract with high lentinic-acid content suppressed the elevation in blood ethanol concentration. Shiitake extract with high lentinic acid suppressed ethanol absorption from stomach and small intestine and promoted ethanol metabolism by inducing alcohol dehydrogenase and aldehyde dehydrogenase.

Academic Significance and Societal Importance of the Research Achievements

近年,食品の生体調節機能に関する研究が盛んに行われているが,その多くは,生理機能にのみ着目し,嗜好性も視野にいれた研究は少ない。本研究は,無味・無臭であるシイタケフレーバー前駆体を用いて,その機能性を明らかにした。本研究の成果は,食品科学において,新たな機能性成分の発見という点でも意義があるが,さらに,シイタケフレーバー前駆体を高含有するシイタケ抽出物が,血中エタノール濃度上昇抑制作用を有することを見出したことから,多成分を含む食品の状態でも,効果が発揮されるということを示したことでも意義がある。本研究の成果は,嗜好性と機能性が高い新たな食品の創製につながることが期待できる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (23 results)

All 2019 2018 2017 2016

All Journal Article (12 results) (of which Peer Reviewed: 10 results,  Open Access: 3 results) Presentation (9 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (2 results)

  • [Journal Article] S-Allyl-L-cysteine sulfoxide, a garlic odor precursor, suppresses elevation in blood ethanol concentration by accelerating ethanol metabolism and preventing ethanol absorption from gut2019

    • Author(s)
      Harumi Uto-Kondo, Ayumu Hase, Yusuke Yamaguchi, Ayaka Sakurai, Makoto Akao, Takeshi Saito, Hitomi Kumagai
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 82 Issue: 4 Pages: 724-731

    • DOI

      10.1080/09168451.2018.1447357

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physicochemical and Surface Properties of Rice Albumin for its Application as a Functional Food Material2019

    • Author(s)
      Shigenobu Ina, Aya Hamada, Tomohiro Kaneko, Natsuko Nakajima, Yusuke Yamaguchi, Makoto Akao, Hitoshi Kumagai, Hitomi Kumagai
    • Journal Title

      Food Science and Technology Research

      Volume: 25

    • NAID

      130007715868

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Study on Improving Sensory and Processing Propertiesas well as Health-promoting Functions of Foods2018

    • Author(s)
      熊谷(佐瀬)日登美
    • Journal Title

      Nippon Shokuhin Kagaku Kogaku Kaishi

      Volume: 65 Issue: 1 Pages: 1-6

    • DOI

      10.3136/nskkk.65.1

    • NAID

      130006320107

    • ISSN
      1341-027X, 1881-6681
    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Wheat gliadin deamidated by cation-exchange resins induces oral tolerance in a mouse model of wheat allergy2018

    • Author(s)
      Ryosuke Abe, Narumi Matsukaze, Yusuke Yamaguchi, Makoto Akao, Hitoshi Kumagai and Hitomi Kumagai
    • Journal Title

      Journal of Food Bioactives

      Volume: 1 Pages: 119-128

    • DOI

      10.31665/jfb.2018.2147

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 酵素反応により生成する含硫フレーバーおよびその前駆体の生理効果2018

    • Author(s)
      山口勇将,熊谷日登美
    • Journal Title

      香料

      Volume: 280号 Pages: 1-9

    • NAID

      40021759986

    • Related Report
      2018 Annual Research Report
  • [Journal Article] おいしさと加工性に優れた食品成分の健康増進機能2018

    • Author(s)
      熊谷日登美
    • Journal Title

      食生活研究会「食と健康」講演会記録

      Volume: 第25回 Pages: 7-28

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Suppressive Effect of the α-Amylase Inhibitor Albumin from Buckwheat (Fagpopyrum esculentum) on Postprandial Hyperglycaemia2018

    • Author(s)
      Kazumi Ninomiya, Shigenobu Ina, Aya Hamada, Yusuke Yamaguchi, Makoto Akao, Fumie Shinmachi, Hitoshi Kumagai, Hitomi Kumagai
    • Journal Title

      Nutrients

      Volume: 10 Issue: 10 Pages: 1503-1516

    • DOI

      10.3390/nu10101503

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of Water Sorption Isotherms of Amorphous Food Materials by Solution Thermodynamics with Relevance to Glass Transition: Evaluation of Plasticizing Effect of Water by the Thermodynamic Parameters2017

    • Author(s)
      Eriko Shimazaki, Akiko Tashiro, Hitomi Kumagai, Hitoshi Kumagai
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 81 Issue: 4 Pages: 743-749

    • DOI

      10.1080/09168451.2016.1277945

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 食品ハイドロコロイドのかたさ・粘度と咽頭部流速2017

    • Author(s)
      秋間彩香,山形文乃,谷米(長谷川)温子,熊谷日登美,熊谷仁
    • Journal Title

      日本食品科学工学会誌

      Volume: 64 Pages: 123-131

    • NAID

      130007331133

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acoustic Analysis of the Swallowing Sound for Food Gels Relevant as Care Foods for Dysphagic Patients2016

    • Author(s)
      秋間彩香,篠原由妃,岡田紗代子,矢野智美,二宮和美,谷米(長谷川)温子,熊谷日登美,熊谷仁
    • Journal Title

      Nippon Shokuhin Kagaku Kogaku Kaishi

      Volume: 63 Issue: 10 Pages: 439-449

    • DOI

      10.3136/nskkk.63.439

    • NAID

      130005170572

    • ISSN
      1341-027X, 1881-6681
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rice (Oryza sativa japonica) Albumin Suppresses the Elevation of Blood Glucose and Plasma Insulin Levels after Oral Glucose Loading2016

    • Author(s)
      Shigenobu Ina, Kazumi Ninomiya, Takashi Mogi, Ayumu Hase, Toshiki Ando, Narumi Matsukaze, Jun Ogihara, Makoto Akao, Hitoshi Kumagai, Hitomi Kumagai
    • Journal Title

      Journal of Agricultural and Food Chemistry

      Volume: 64 Issue: 24 Pages: 4882-4890

    • DOI

      10.1021/acs.jafc.6b00520

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 嚥下困難者用介護食の基礎としての食品ゲルの嚥下音に関する音響解析2016

    • Author(s)
      秋間彩香,篠原由妃,谷米(長谷川)温子,石原清香,礒野舞,中馬誠,中尾理美,船見孝博,熊谷日登美,熊谷仁
    • Journal Title

      日本食品科学工学会誌

      Volume: 63 Pages: 439-449

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 種々のシイタケ中のレンチニン酸含量の定量2018

    • Author(s)
      藤澤望,中条早紀,營田雄大,権守千晴,山口勇将,大槻崇,赤尾真,松藤寛,熊谷日登美
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2018 Annual Research Report 2017 Research-status Report
  • [Presentation] シイタケ臭気前駆体レンチニン酸による血中アルコール濃度上昇抑制2018

    • Author(s)
      櫻井彩夏,梅原彩花,陸陣陣,山口勇将,赤尾真,近藤春美,斉藤武, 熊谷日登美
    • Organizer
      第72回日本栄養・食糧学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] シイタケ臭気前駆体による血中アルコール濃度上昇抑制2018

    • Author(s)
      坂口智哉,櫻井彩夏,山口勇将,近藤春美,赤尾真,斉藤武,熊谷日登美
    • Organizer
      日本農芸化学会関東支部2018年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Suppressive Effect on Blood-ethanol Elevation by Shiitake Extract Containing Lentinic Acid2018

    • Author(s)
      Ayaka Sakurai, Yusuke Ueno, Yusuke Yamaguchi, Makoto Akao, Harumi Kondo, Takeshi Saito, Hitomi Kumagai
    • Organizer
      Asia-Pacific Nutrigenomics Nutrigenetics Organisation (APNNO BIENNIAL CONFERENCE)
    • Related Report
      2018 Annual Research Report
  • [Presentation] α-シクロデキストリンで包接されたレンチオニンの安定性とその血小板凝集抑制作用2017

    • Author(s)
      中条早紀,島田正一郎,櫻井彩夏,関祐作,赤尾真,熊谷日登美
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学(京都府・京都市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Suppression of Blood-ethanol Elevation by Shiitake Extract Containing Lentinic Acid2017

    • Author(s)
      Ayaka Sakurai, Ayaka Umehara, Zhenzhen Lu, Yusuke Yamaguchi, Makoto Akao, Harumi Kondo, Takeshi Saito, Hitomi Kumagai
    • Organizer
      The 10th International Conference and Exhibition on Functional Foods, Nutraceuticals and Dietary Supplements (ICoFF 20117)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Encapsulation of Shiitake (Lentinus edodes) Flavor in α-Cyclodextrin2017

    • Author(s)
      Saki Nakajo, Yuta Tsukuta, Chiharu Gonmori, Shoichiro Shimada, Yusuke Yamaguchi, Makoto Akao, Hitomi Kumagai
    • Organizer
      The 10th International Conference and Exhibition on Functional Foods, Nutraceuticals and Dietary Supplements (ICoFF 20117)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] シイタケ抽出物中のレンチニン酸の検出とその四塩化炭素誘発肝障害抑制効果2016

    • Author(s)
      渡辺彩,荒川遙,平井眞実,赤尾真,熊谷日登美
    • Organizer
      第70回日本栄養・食糧学会大会
    • Place of Presentation
      武庫川女子大学 中央キャンパス(兵庫県・西宮市)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
  • [Presentation] Suppression of Blood-Ethanol Elevation by Compounds Produced from Dipeptide and Amino Acid in Shiitake Mushrooms2016

    • Author(s)
      Hitomi Kumagai, So Hironaka, Makoto Akao
    • Organizer
      107th AOCS Annual Meeting & Expo
    • Place of Presentation
      Salt Palace Convention Center, Salt Lake City, Utah, USA
    • Year and Date
      2016-05-01
    • Related Report
      2016 Research-status Report
    • Invited
  • [Book] 血流改善成分の開発と応用 第11章 含硫フレーバー(ニンニク,シイタケ等)2018

    • Author(s)
      山口勇将,熊谷日登美 (監修:大澤俊彦)
    • Publisher
      シーエムシー出版
    • ISBN
      9784781313412
    • Related Report
      2018 Annual Research Report
  • [Book] Deamidation of gluten proteins as a tool for improving the properties of bread in "Flour and Breads and their Fortification in Health and Disease Prevention"2018

    • Author(s)
      Hitomi Kumagai, Reiko Urade (Editor: Victor R. Preedy and Ronald Ross Watson)
    • Publisher
      Academic Press, Elsevier
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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