Identificaiton of nutritional factors which suppress SASP

• Project/Area Number: 16K00878
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Sugiyama Jogakuen University
• Principal Investigator: MOTOYAMA NOBORU 椙山女学園大学, 生活科学部, 教授 (50277282)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 細胞老化 / 老化 / SASP / 炎症 / 食品 / 炎症性サイトカイン / 老年病 / 健康寿命 / シグナル伝達

Outline of Final Research Achievements

Cellular senescence, especially senescence-associated secretory phenotype (SASP), have been implicated in the development of several age-related diseases and aging. Thus, the regulation of SASP is a potent target for preventive and clinical treatment of age-related diseases. In this study, I have identified the components derived from food and natural product which suppress SASP. Carotenoid in water melon and alkaroid in Evodia rutaecarpa suppressed the expression of SASP components without inhibiting cellular senescence induction.

Academic Significance and Societal Importance of the Research Achievements

老化および老年性疾患の発症に関与する細胞老化付随分泌現象（SASP）を抑制する天然物・食品由来の成分の同定を行った。これらの研究成果から薬ではなく「食の面から健康を支える」ことのできる予防効果が期待される食品・天然物を示すことができる可能性が期待される。

Research Products

• [Journal Article] Differential roles of Rad18 and Chk2 in genome maintenance and skin carcinogenesis following UV exposure. (2018)
  • Author(s): Tanoue, Y., Toyoda, T., Sun, J, Mustofa, M.K., Tateishi, C., Endo, S., Motoyama, N., Araki, K., Wu, D., Okuno, Y., Tsukamoto, T., Takeya, M., Ihn, H., Vaziri, C., Tateishi, S.
  • Journal Title: J. Invest. Dermatol. Volume: 138 Issue: 12 Pages: 2550-2557
  • DOI: 10.1016/j.jid.2018.05.015
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] CHK2 is involved in the p53-independent radiosensitizing effects of valproic acid (2017)
  • Author(s): 65.Choo DW, Goh SH, Cho YW, Baek HJ, Park EJ, Motoyama N, Kim TH, Kim JY, Kim SS.
  • Journal Title: Oncology Letter Volume: 13 Issue: 4 Pages: 2591-2598
  • DOI: 10.3892/ol.2017.5792
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 細胞の老化を標的とした健康寿命延長ー栄養学との接点ー (2017)
  • Author(s): 本山 昇
  • Journal Title: 生活の科学 Volume: 39 Pages: 17-20
  • NAID: 120007117118
• [Presentation] SIRT1 regulates the expression of p21 during cellular senescence (2018)
  • Author(s): 33.Hayakawa T. Morimoto R, Kimura Y, Nagasaki M, Nagata M, Maruyama M, Motoyama N
  • Organizer: Aging and Metabolism, Cell Symposia
  • Int'l Joint Research
• [Presentation] p21 negatively regulates DNA damage-induced pro-inflammatory response during senescence (2018)
  • Author(s): 32.Hayakawa T, Kimura Y, Nagasaki M, Nagata M, Morimoto R, Maruyama M, Motoyama N
  • Organizer: “Aging, Inflammation and Immunity”, Keystone Symposia
  • Int'l Joint Research
• [Presentation] がん化と老化を制御する細胞老化とＳＡＳＰ (2017)
  • Author(s): 本山 昇
  • Organizer: 第40回日本基礎老化学会大会
  • Invited