| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Effects of lipid quality on the manifestation of lifestyle-related diseases, fatty liver and brain function disorders were evaluated. The study demonstrated the n-3 PUFA-PLs (EPA & DHA) prevented fatty liver and EPA-phospholipids (PLs and plasmalogen) alleviated atherosclerosis in mice. n-3 PUFA-PLs alleviated exercise fatigue and extended the time and distance to running exhaustion as well as inhibiting glycogen consumption and muscle injury. n-3 PUFA-PLs improved memory and learning performance and reduced Aβ level in the brain of Alzheimer’s disease (AD) model mice (DHA > EPA). DHA-PC and EPA-PC alleviated oxidative stress and inflammation as well as apoptosis and autophagy in the brain. These improvements in cognitive function were observed even with egg-phosphatidylcholine (PC) that did not contain DHA, but the effect was limiting.
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