| Project/Area Number |
16K00903
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Osaka City General Hospital |
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Principal Investigator |
Shirano Michinori 地方独立行政法人大阪市民病院機構大阪市立総合医療センター(臨床研究センター), 臨床研究センター, 医長 (00727638)
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| Co-Investigator(Kenkyū-buntansha) |
羽生 大記 大阪市立大学, 大学院生活科学研究科, 教授 (40301428)
庄司 久美子 (加藤久美子 / 加藤 久美子) 女子栄養大学, 栄養学部, 助教 (50721825)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | HIV / AIDS / 低栄養 / CD4陽性リンパ球数 / CD4カウント / レプチン / CONUT / メタボリックシンドローム / エイズ / 栄養障害 |
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| Outline of Final Research Achievements |
To clarify the improvement effect of the immune response by the improvement of nutritional status, we conducted nutrition intervention for the low CD4 counts HIV-positive patients (CD4<500/μL) who are diagnosed as the mild malnutrition by CONUT. 1) Whether ingesting Ensure Liquid (250kcal) for three months will improve the CD4 counts (whether the CD4 count increase by 30% or more), 2) Whether the body fat mass and serum leptin concentration increase. We conducted a randomized controlled trial with crossover to investigate the effects of nutrition. Although nutritional addition showed a significant increase in body weight and a tendency to increase serum leptin levels, no change was observed in CD4 counts.
This is the first study to use the CONUT for nutrition evaluation of HIV-positive patients.It is necessary to examine the association of CONUT malnutrition with the change in immune response and other HIV related outcomes by a cohort study. This study will be the basic data for that.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で栄養評価に用いたCONUTは、入院患者のスクリーニングや軽度の栄養障害を抽出するのに適しているとされるが、HIV陽性者の栄養評価に用いたのは本研究が初めてであり、今後、コホート研究により、CONUT栄養不良者の免疫能の変化やその他HIVに関連したアウトカムとの関連を検討することが必要であり、本研究はそのための基礎データとなると考える。
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