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The risk of Alzheimer's disease in the developing countries: Relationship between diet and environment

Research Project

Project/Area Number 16K00909
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionSuzuka University (2019-2022)
Mie University (2016-2018)

Principal Investigator

Midorikawa Kaoru  鈴鹿大学, こども教育学部, 教授 (20393366)

Co-Investigator(Kenkyū-buntansha) 村田 真理子  三重大学, 医学系研究科, 教授 (10171141)
中村 哲  広島文化学園大学, 看護学部, 教授 (40207874)
翠川 裕  三重大学, 医学系研究科, リサーチアソシエイト (10209819)
Project Period (FY) 2016-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsアルツハイマー / ラオス / 生活環境 / 国際保健 / 生活習慣病 / 国際研究者交流 / 東南アジア / 高齢者 / 認知症 / APOE / アルツハイマー病
Outline of Final Research Achievements

Since 2005, we have been conducting health surveys in Laos, a developing country. In recent years, lifestyle-related diseases such as diabetes and hypertension have increased along with economic development. Between 2017 and 2019, we conducted for health examinations of aged over 60, and compared with the results between 2007 and 2008. We found that weight, blood sugar, and HbA1c values increased significantly. The number of people with BMI of 25 or higher has doubled, high blood pressure increased about 1.6 times, and suspected diabetes increased 2-3 times. In addition, the number of people suspected of having dementia with a dementia scale of 20 or less has increased by about 1.5 times over the last 10 years. Among the causes of death of the subjects, diabetes-related deaths occupy for 50%. There is concern about an increase in dementia such as Alzheimer's disease along with an increase in lifestyle-related diseases in the future.

Academic Significance and Societal Importance of the Research Achievements

AD根治への治療法はいまだ確立されておらず、早期発見と予防が重要と考えられている。 AD は、有病率の人種差が大きく、APOE 遺伝子型に関しても、その発症率とは必ずしも相関しておらず、運動と禁煙等の生活習慣における予防効果が特に高いと言われている。ラオスでの遺伝子調査は我々の先行研究のみであり、AD 発症がきわめて低い現状から環境因子や生活習慣を調査しておくことは大変意義があると考える。ラオスでは、依然感染症対策が重要課題であるが、認知症対策の重要性は認識されており国際貢献としての責務は重要である。本研究は、医療費問題、社会問題の解決につながる成果が期待されることから大変意義があると考える。

Report

(8 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (44 results)

All 2023 2022 2021 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (7 results) Journal Article (9 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 9 results,  Open Access: 7 results,  Acknowledgement Compliant: 2 results) Presentation (25 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Book (1 results) Patent(Industrial Property Rights) (2 results)

  • [Int'l Joint Research] 国立マホソート病院(ラオス)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] 国立マホソート病院(ラオス)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] 国立マホソート病院(ラオス)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] 国立マホソート病院(ラオス)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] Mahosoto Hospital(ラオス)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] ラオス国立マホソート病院(ラオス)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] ラオス国立マホソート病院(ラオス)

    • Related Report
      2016 Research-status Report
  • [Journal Article] ラオス人民民主共和国の肺吸虫種と中間宿主および肺吸虫症2023

    • Author(s)
      波部重久、八尋眞一郎、中村哲
    • Journal Title

      看護学統合研究

      Volume: 24巻2号 Pages: 1-13

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GDF10 inhibits cell proliferation and epithelial-mesenchymal transition in nasopharyngeal carcinoma by the transforming growth factor-β/Smad and NF-κB pathways2022

    • Author(s)
      He Feng、Feng Guofei、Ma Ning、Midorikawa Kaoru、Oikawa Shinji、Kobayashi Hatasu、Zhang Zhe、Huang Guangwu、Takeuchi Kazuhiko、Murata Mariko
    • Journal Title

      Carcinogenesis

      Volume: 43 Issue: 2 Pages: 94-103

    • DOI

      10.1093/carcin/bgab122

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prevalence of anemia and its associated factors among children aged 6?59 months in the Lao People’s Democratic Republic: A multilevel analysis2021

    • Author(s)
      Keokenchanh Sengtavanh、Kounnavong Sengchanh、Midorikawa Kaoru、Ikeda Wakaha、Morita Akemi、Kitajima Takumi、Sokejima Shigeru
    • Journal Title

      PLOS ONE

      Volume: 16(3) Issue: 3 Pages: 8969-8969

    • DOI

      10.1371/journal.pone.0248969

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prevalence of Anemia and Its Associate Factors among Women of Reproductive Age in Lao PDR: Evidence from a Nationally Representative Survey2021

    • Author(s)
      Sengtavanh Keokenchanh, Sengchanh Kounnavong, Akiko Tokinobu, Kaoru Midorikawa, Wakaha Ikeda, Akemi Morita, Takumi Kitajima, and Shigeru Sokejima
    • Journal Title

      Hindawi, Anemia

      Volume: 2021 Pages: 1-9

    • DOI

      10.1155/2021/8823030

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Symbiosis of Salmonella and Escherichia coli by MY Phenomenon2020

    • Author(s)
      Yutaka Midorikawa, Satoshi Nakamura, Yusuke Wakasugi, Kaoru Midorikawa
    • Journal Title

      Open Journal of Medical Microbiology

      Volume: 10 Pages: 17-25

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] サルモネラ硫化水素産生による銀および銅の抗菌性比較評価2018

    • Author(s)
      翠川裕、中井正明、新家光雄
    • Journal Title

      銅と銅合金(Journal of Japan institute of copper)

      Volume: 57 Pages: 318-322

    • NAID

      40021651193

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Detection of <i>Salmonella</i> in That Luang Marsh, Vientiane, Lao PDR: Improvement of the Accuracy of <i>Salmonella</i> Detection Using Visualization of Hydrogen Sulfate Production by <i>Salmonella</i>2017

    • Author(s)
      翠川裕
    • Journal Title

      Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)

      Volume: 72 Issue: 2 Pages: 95-100

    • DOI

      10.1265/jjh.72.95

    • NAID

      130005680593

    • ISSN
      0021-5082, 1882-6482
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] APOE Genotype in the Ethnic Majority and Minority Groups of Laos and the Implications for Non-Communicable Diseases.2016

    • Author(s)
      Midorikawa K, Soukaloun D, Akkhavong K, Southivong B, Rattanavong O, Sengkhygnavong V, Pyaluanglath A, Sayasithsena S, Nakamura S, Midorikawa Y, Murata M.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 5 Pages: 1-15

    • DOI

      10.1371/journal.pone.0155072

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Risk of salmonella in a suburban region of Vientiane, Lao People's Democratic Republic2016

    • Author(s)
      Yutaka Midorikawa, Satoshi Nakamura, Rattanaphone Phetsouvanh, Manivanh Vongsouvaht, Kaoru Midorikawa
    • Journal Title

      Southeast Asian J Trop Med Public Health

      Volume: 47(5) Pages: 970-975

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] ラオスにおける生活習慣病関連遺伝子の多型解析2023

    • Author(s)
      翠川薫、ウーダボン・ラタナボン、中村哲、翠川裕、村田真理子
    • Organizer
      第93回日本衛生学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] サルモネラの増殖可視化を用いたMTA合金の抗菌性証明2023

    • Author(s)
      翠川裕、柴田徹郎、翠川薫
    • Organizer
      第93回日本衛生学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Knockdown of transferrin receptor inhibits the development of nasopharyngeal carcinoma via PI3K-Akt pathway2023

    • Author(s)
      馮国飛、馬寧、翠川薫、及川伸二、小林果、竹内万彦、ジャオ・ウェイリン、ジャ・ジョ、村田真理子
    • Organizer
      第93回日本衛生学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Knockdown of transferrin receptor suppresses cell proliferation and invasion of nasopharyngeal carcinoma2022

    • Author(s)
      馮国飛、馬寧、翠川薫、及川伸二、小林果、竹内万彦、Weilin Zhao 、Zhe Zhang、村田真理子
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ラオスにおける高齢者の生活習慣病の現状について2022

    • Author(s)
      翠川薫、ウーダボン・ラタナボン、中村哲、翠川裕、村田真理子
    • Organizer
      第92回日本衛生学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] COVID-19流行開始下のフィリピン・レイテ島の飲料水の衛生状況2022

    • Author(s)
      中村哲、ルエタス-ラバトゥス ローリー、翠川裕、翠川薫、大竹英博
    • Organizer
      第92回日本衛生学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] GDF10 suppresses the progression of nasopharyngeal carcinoma by regulating TGF-β/Smad/NF-κB axis2022

    • Author(s)
      Guofei Feng、Feng He、有馬寧、翠川薫、及川伸二、小林果、竹内万彦、 村田真理子
    • Organizer
      第92回日本衛生学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Association of Epstein-Barr virus, human papillomavirus and MIF with macrophage polarization in nasopharyngeal carcinoma2021

    • Author(s)
      Guofei Feng, Yifei Xu, Ning Ma, Kaoru Midorikawa, Shinji Oikawa, Kazuhiko Takeuchi, Mariko Murata.
    • Organizer
      第80回日本癌学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] ラオスにおける6-59か月児の貧血は深刻な公衆衛生上の問題である2021

    • Author(s)
      キョウケンチャン・センタバン、クンナボン・センチャン、翠川薫、池田若葉、森田明美、北島巧海、そうけ島茂
    • Organizer
      第91回日本衛生学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 「果糖輸送体GLUT5の発現抑制は胆管癌細胞の増殖と遊走を阻害する」2021

    • Author(s)
      スワナクル・ナタワン、翠川薫、小林果、及川伸二、有馬寧、川西正祐、村田真理子
    • Organizer
      第91回日本衛生学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] トランスフェリン受容体タンパク質1のノックダウンは上咽頭癌の細胞増殖を抑制する2021

    • Author(s)
      馮国飛、有馬寧、翠川薫、小林果、及川伸二、竹内万彦、村田真理子
    • Organizer
      第91回日本衛生学会学術集会 2021年3月6~8日 オンライン開催(富山県)
    • Related Report
      2020 Research-status Report
  • [Presentation] 血漿DNAを用いた上咽頭癌の新規スクリーニングバイオマーカー2020

    • Author(s)
      徐軼菲、趙蔚林、莫穎禧、馬寧、翠川薫、小林果、平工雄介、及川伸二、張哲、黄光武、竹内万彦、村田真理子
    • Organizer
      第79回日本癌学会学術集会 2020年10月1~3日 リーガロイヤルホテル広島(広島県)
    • Related Report
      2020 Research-status Report
  • [Presentation] Fructose promotes cholangiocarcinoma cell proliferation via GLUT5 overexpression2020

    • Author(s)
      Nattawan Suwannakul, Kaoru Midorikawa, Shinji Oikawa, Hatasu Kobayashi, Ning Ma, Shosuke Kawanishi, Mariko Murata
    • Organizer
      第79回日本癌学会学術集会 2020年10月1~3日 リーガロイヤルホテル広島(広島県)
    • Related Report
      2020 Research-status Report
  • [Presentation] 上咽頭癌におけるEpstein-Barr ウィルスとヒトパピローマウイルスの in situ hybridizationによる検討2020

    • Author(s)
      馮国飛、馬寧、翠川薫、小林果、及川伸二、竹内万彦、村田真理子
    • Organizer
      第79回日本癌学会学術集会 2020年10月1~3日 リーガロイヤルホテル広島(広島県)
    • Related Report
      2020 Research-status Report
  • [Presentation] ラオス首都ビエンチヤン近郊お農村における寄生虫卵保有及びサルモネラの保菌2020

    • Author(s)
      翠川裕
    • Organizer
      第90回日本衛生学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 頭頚部扁平上皮癌におけるTFRCとSLC40A1の発現異常と臨床的意義2020

    • Author(s)
      Guofei Foeng, 有馬寧、翠川薫、小林果、及川伸二、竹内万彦、村田真理子
    • Organizer
      第90回日本衛生学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 上咽頭癌におけるがん幹細胞マーカーCD44v9と炎症関連DNA損傷との関係2020

    • Author(s)
      何峰、馬寧、川西正祐、翠川薫、小林果、及川伸二、竹内万彦、村田真理子
    • Organizer
      第90回日本衛生学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 上咽頭癌のメチル化DNAバイオマーカーの検討2020

    • Author(s)
      除軼菲、有馬寧、翠川薫、小林果、及川伸二、竹内万彦、村田真理子
    • Organizer
      第90回日本衛生学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 胆管癌進展におけるCD44variant9の役割2020

    • Author(s)
      Nattawan Suwannakul、翠川薫、小林果、及川伸二、有馬寧、川西正祐、村田真理子
    • Organizer
      第90回日本衛生学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] フィリピン巨大台風災害5年後の被災地の水質について2019

    • Author(s)
      中村 哲、翠川 裕、翠川 薫、Lory L. Ruetas, Lyn L. Verona
    • Organizer
      第60回 日本熱帯医学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] ラオスコクサー村における住民のサルモネラ保菌の現状2019

    • Author(s)
      翠川裕
    • Organizer
      第89回 日本衛生学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Changes in the quality of drinking water sources in the affected areas of Leyte Island and Samar Island four years after the Yolanda disaster in the Philippines2018

    • Author(s)
      Satoshi Nakamura, Lory Labatos-Ruetas, Amelita Adenido, Yutaka Midorikawa, Kaoru Midorikawa, John Edward M. Coloma
    • Organizer
      The 14th Asia Pacific Conference on Disaster Medicine in Kobe, Japan
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 「地球温暖化と感染症」2018

    • Author(s)
      翠川裕
    • Organizer
      第88回日本衛生学会学術総会 自由集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] ラオスビエンチャンタートルアン湿原からのサルモネラ検出2017

    • Author(s)
      翠川裕、中村哲、翠川薫
    • Organizer
      第87回日本衛生学会学術総会
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎県・宮崎市)
    • Year and Date
      2017-03-26
    • Related Report
      2016 Research-status Report
  • [Presentation] ラオスにおけるAPOE遺伝子型と生活習慣病2017

    • Author(s)
      翠川薫、中村哲、翠川裕、村田真理子
    • Organizer
      第16回分子予防環境医学研究会大会
    • Place of Presentation
      熊本市国際交流会館(熊本県・熊本市)
    • Year and Date
      2017-02-03
    • Related Report
      2016 Research-status Report
  • [Book] Molecular Aspects of Alcohol and Nutrition: A Volume in the Molecular Nutrition Series2016

    • Author(s)
      Murata M, Midorikawa K, Kawanishi S.
    • Total Pages
      369
    • Publisher
      Elsevier Science & Technology
    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] 線維筋痛症の診断薬2019

    • Inventor(s)
      翠川裕
    • Industrial Property Rights Holder
      翠川裕
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Acquisition Date
      2019
    • Related Report
      2019 Research-status Report
  • [Patent(Industrial Property Rights)] 菌の検査方法2019

    • Inventor(s)
      翠川裕
    • Industrial Property Rights Holder
      翠川裕
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Acquisition Date
      2019
    • Related Report
      2019 Research-status Report

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Published: 2016-04-21   Modified: 2024-01-30  

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