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Basic studies of the conditioned aversion learning elicited by mixed stimuli of foods as CS

Research Project

Project/Area Number 16K00924
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionAsahi University

Principal Investigator

Sako Noritaka  朝日大学, 歯学部, 教授 (90243154)

Co-Investigator(Kenkyū-buntansha) 諏訪部 武  朝日大学, 歯学部, 准教授 (00610312)
安尾 敏明  朝日大学, 歯学部, 助教 (30608469)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords食物嫌悪学習 / 味覚 / 口腔感覚 / 味覚神経 / 混合味 / 味覚嫌悪学習 / 味質識別 / 食行動
Outline of Final Research Achievements

Our behavioral study by using of the conditioned taste aversion (CTA) learning method found that rats could recognize the component of mixed taste solutions, but that partner component obstructed the recognition of the other one in concentration - dependent. Our electrophysiological study found that this obstruction occurred in lower level than taste nerve. The rats denervated glossopharyngeal (GL) as well as chorda tympani (CT) nerves could recognize the component of mixed taste solutions. But the rats denervated CT nerve took longer time to acquire the CTA than GL denrevated group. The time presented mixed taste solution as conditioned stimulus (CS) was lower than 1 min to recognize the component of CS for rats.

Academic Significance and Societal Importance of the Research Achievements

我々ヒトは通常、単一化学物質ではなく複数の化学物質の混在した複合混合物を摂取している。従来の味覚研究は、あくまでも単一味物質を対象としたものがほとんどであり、この観点で研究を続ける限り、ヒトの食行動の本質を解明するには程遠いと考える。本研究では、行動学的および神経科学的実験法を駆使し、本来ヒトが摂取している食物の、混合化学物質の味がどのように認知され、混合物間でどのような相互作用をもち、また、その神経基盤がどうなっているかを調べた基礎的研究であり、今後の〝本来あるべき〟ヒトの食行動の解明に大きな一歩を踏み出したものであることを自負するものである。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (12 results)

All 2019 2018 2017 2016

All Journal Article (1 results) Presentation (11 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] 2種類の味物質混合により生じたラット鼓索神経応答の抑制2018

    • Author(s)
      山村知暉、安尾敏明、諏訪部武、硲哲崇
    • Journal Title

      日本味と匂学会第52回大会Proceeding集

      Volume: -

    • Related Report
      2018 Annual Research Report
  • [Presentation] Behavioral and neural characteristics of recognition of the binary taste mixture in rats2019

    • Author(s)
      Tomoki Yamamura, Yoshihisa Katagawa, Toshiaki Yasuo, Takeshi Suwabe and Noritaka Sako
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 嗜好性の異なる混合味溶液の識別とそれに関わる神経の検索2018

    • Author(s)
      山村知暉、安尾敏明、諏訪部武、硲哲崇
    • Organizer
      第3回食欲・食嗜好の分子・神経基盤研究会(食欲・食嗜好研究会)
    • Related Report
      2018 Annual Research Report
  • [Presentation] ショ糖にキニーネ、または塩酸を混合した混合味溶液刺激時のラット鼓索神経応答2018

    • Author(s)
      山村知暉、安尾敏明、諏訪部武、硲哲崇
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 2種混合味溶液を呈示されたラットの鼓索神経応答の特徴2018

    • Author(s)
      山村知暉、安尾敏明、諏訪部武、硲哲崇
    • Organizer
      日本味と匂学会第52回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Recognition of the component of the binary taste mixtures in the rats denervated taste nerves2018

    • Author(s)
      Yamamura, T., Yasuo, T., Suwabe, T. and Sako, N.
    • Organizer
      The 95th Annual Meetings of the Physiological Society of Japan
    • Related Report
      2017 Research-status Report
  • [Presentation] Suppression of the taste intensity of paired component in the binary taste mixture of sweet and bitter may occur reciprocally2017

    • Author(s)
      Yamamura, T., Yasuo, T., Suwabe, T. and Sako, N.
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松市
    • Year and Date
      2017-03-29
    • Related Report
      2016 Research-status Report
  • [Presentation] 嗜好性の異なる味溶液を混合した場合にその識別性はどのように変化するか?2017

    • Author(s)
      片川吉尚、山村知暉、山田茂貴、安尾敏明、諏訪部武、玄景華、硲哲崇
    • Organizer
      第2回食欲・食嗜好の分子神経基盤研究会(食欲・食嗜好研究会)
    • Related Report
      2017 Research-status Report
  • [Presentation] ラットにおける混合味溶液中の含有味溶液認識に及ぼす溶液濃度の影響2017

    • Author(s)
      山村知暉、安尾敏明、諏訪部武、硲哲崇
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 混合味溶液含有成分に味覚嫌悪を条件づけられたラットの甘味+苦味または甘味+酸味2種混合溶液への般化2017

    • Author(s)
      山村知暉、安尾敏明、諏訪部武、硲哲崇
    • Organizer
      日本味と匂学会第51回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] How do the rats recognize individual components of mixed taste solutions?2017

    • Author(s)
      Yamamura, T,, Katagawa, Y., Yamada, S., Yasuo, T., Suwabe, T., Gen, K. and Sako, N.
    • Organizer
      The 16th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Intensity, recognition and hedonic ratengs for the binary taste stimuli in human and rats2016

    • Author(s)
      Katagawa, Y., Yamada, S., Yasuo, T., Suwabe, T., Gen, K. and Sako, N.
    • Organizer
      17th International Symposium on Olfaction and Taste (ISOT2016)
    • Place of Presentation
      横浜市
    • Year and Date
      2016-06-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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