Basic studies of the conditioned aversion learning elicited by mixed stimuli of foods as CS
| Project/Area Number |
16K00924
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Asahi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
諏訪部 武 朝日大学, 歯学部, 准教授 (00610312)
安尾 敏明 朝日大学, 歯学部, 助教 (30608469)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 食物嫌悪学習 / 味覚 / 口腔感覚 / 味覚神経 / 混合味 / 味覚嫌悪学習 / 味質識別 / 食行動 |
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| Outline of Final Research Achievements |
Our behavioral study by using of the conditioned taste aversion (CTA) learning method found that rats could recognize the component of mixed taste solutions, but that partner component obstructed the recognition of the other one in concentration - dependent. Our electrophysiological study found that this obstruction occurred in lower level than taste nerve. The rats denervated glossopharyngeal (GL) as well as chorda tympani (CT) nerves could recognize the component of mixed taste solutions. But the rats denervated CT nerve took longer time to acquire the CTA than GL denrevated group. The time presented mixed taste solution as conditioned stimulus (CS) was lower than 1 min to recognize the component of CS for rats.
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| Academic Significance and Societal Importance of the Research Achievements |
我々ヒトは通常、単一化学物質ではなく複数の化学物質の混在した複合混合物を摂取している。従来の味覚研究は、あくまでも単一味物質を対象としたものがほとんどであり、この観点で研究を続ける限り、ヒトの食行動の本質を解明するには程遠いと考える。本研究では、行動学的および神経科学的実験法を駆使し、本来ヒトが摂取している食物の、混合化学物質の味がどのように認知され、混合物間でどのような相互作用をもち、また、その神経基盤がどうなっているかを調べた基礎的研究であり、今後の〝本来あるべき〟ヒトの食行動の解明に大きな一歩を踏み出したものであることを自負するものである。
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Report
(4 results)
Research Products
(12 results)
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[Presentation] How do the rats recognize individual components of mixed taste solutions?2017
Author(s)
Yamamura, T,, Katagawa, Y., Yamada, S., Yasuo, T., Suwabe, T., Gen, K. and Sako, N.
Organizer
The 16th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
Related Report
Int'l Joint Research
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[Presentation] Intensity, recognition and hedonic ratengs for the binary taste stimuli in human and rats2016
Author(s)
Katagawa, Y., Yamada, S., Yasuo, T., Suwabe, T., Gen, K. and Sako, N.
Organizer
17th International Symposium on Olfaction and Taste (ISOT2016)
Place of Presentation
横浜市
Year and Date
2016-06-06
Related Report
Int'l Joint Research
