| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
This study aimed to identify noninvasive biomarkers for the early detection of nonalcoholic steatohepatitis (NASH). Initially, heterogeneous nuclear ribonucleoprotein M (HNRNPM) was identified as a glycated protein from cultured cells treated with fructose for glycation. Subsequently, changes in gene expression in cells subjected to the attenuation of HNRNPM function were analyzed. The expression levels of multiple genes, including RAS guanyl-releasing protein 2, had either increased or decreased.
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