Mechanisms of memory decline caused by aging and/or mild cognitive impairment: magnetoencephalographic study
| Project/Area Number |
16K01345
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大槻 美佳 北海道大学, 保健科学研究院, 准教授 (10372880)
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| Research Collaborator |
ONO Yumie
KURIKI Shinya
Riitta Hari
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 短期記憶 / 加齢 / 軽度認知障害 / 脳磁場 / 脳律動 / 記憶 / 高齢化 / 脳磁計 / α波律動 / 脳機能計測 |
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| Outline of Final Research Achievements |
Mechanisms of memory decline caused by aging and/or mild cognitive impairments (MCI) have been investigated by using our proposed sequential memory task in which seven arrow images were presented sequentially. Magnetoencephalogram of young and elder participants were recorded during performing the sequential memory task. The results suggested that some brain regions (e.g., precuneous, vicinity of visual area, working memory area) are less activated by aging and/or MCI. Additionally, it is alo suggested that aging prolongs the process for visual inputs and transfer. The memory decline probably relies on these less-activity and prolonged process.
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| Academic Significance and Societal Importance of the Research Achievements |
日本の高齢者（65歳以上）の人口に占める割合は、2020年には30％、2060年には40％に達する。高齢者の認知機能の低下、特に記憶能力の低下は本人のみならず、社会全体にとっても重要な問題である。日常生活に大きな支障のない軽度認知障害（MCI: Mild Cognitive Impairment）は認知症の前段階であり、初期から記憶能力の低下を伴うが、症状の軽減や回復が可能である。加齢やMCIによる記憶能力低下のプロセスの一端が本研究成果により明らかになったことで、MCI段階で記憶能力の低下を抑止する方法が考案できるようになる。
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Report
(4 results)
Research Products
(167 results)
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[Journal Article] Sub-classification of apraxia of speech in patients with cerebrovascular and neurodegenerative diseases2019
Author(s)
Yuki Takakura, Mika Otsuki, Shinya Sakai, Yasutaka Tajima, Yasunori Mito, Akihiko Ogata, Shuichi Koshimizu, Masami Yoshino, Genki Uemori, Satoko Takakura, Yoshitsugu Nakagawa.
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Journal Title
Brain and Cognition
Volume: 130
Pages: 1-10
DOI
Related Report
Peer Reviewed
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[Journal Article] A cross-culture comparison of tonality perception in Japanese, Chinese, Vietnamese, Indonesian, and American listeners2018
Author(s)
Matsunaga, R., Yasuda, T., Johnson-Motoyama, M., Hartono, P., Yokosawa, K., & Abe, J.
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Journal Title
Psychomusicology: Music, Mind, and Brain
Volume: 28
Pages: 178-188
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Changes in Pupils Diameter are Correlated with the Occurremce of Pareidolias in Patients with Dementia with Lewy Bodies2017
Author(s)
Yumi Suzuki, Hirayama Kazumi, Tasuo Shimomura, Makoto Uchiyama, Hiromi Fujii, Etsuro Mori, Yoshiyuki Nishio, Osamu Iizuka, Tyousuke Inoue, Mika Otsuki, Shinya Sakai
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Journal Title
Neuroreport
Volume: 28
Pages: 187-192
DOI
Related Report
Peer Reviewed
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[Presentation] Longitudinal investigation of the symptoms and the imaging findings of NFVPPA: subclassification for nosology2017
Author(s)
M Otsuki, Y. Nakagawa, K. Kondo, H. Houzen, S. Hamada, Y. Tajima, Y. Mito, S. Koshimizu, A. Ogata, S. Ura, Y. Kuroshima, K. Yoshida, I. Yabe, H. Sasaki
Organizer
23rd World Congress of Neurology
Related Report
Int'l Joint Research
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[Presentation] Spatiotemporal human brain activities on recalling fruit names2016
Author(s)
Koji Sugimoto, Takahiro Yamanoi, Hisashi Toyoshima, Mika Otsuki, Shin-ichi Ohnishi, and Toshimasa Yamazaki
Organizer
Joint 8th International Conference on Soft Computing and Intelligent Systems and 17th International Symposium on Advanced Intelligent Systems
Place of Presentation
Sapporo, Japan
Year and Date
2016-08-25
Related Report
Int'l Joint Research / Invited
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