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Simulation and assessment of phosphene image induced with the visual cortical prosthesis predicted from the neuronal activities in the visual cortex.

Research Project

Project/Area Number 16K01354
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionOsaka University

Principal Investigator

Yagi Tetsuya  大阪大学, 工学研究科, 教授 (50183976)

Co-Investigator(Kenkyū-buntansha) 林田 祐樹  大阪大学, 工学研究科, 准教授 (10381005)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords人工視覚 / 光覚 / 視覚野 / 電気刺激 / 生理実験 / シミュレーション / 電極配置 / 心理物理実験 / 視覚野電気刺激 / 視覚野応答 / 光覚パターン / 刺激パターン / イメージング / 電位感受性色素 / 仮想視覚野 / シリコン網膜 / ウェアラブルシミュレータ / バーチャルリアリティ / 視覚野刺激
Outline of Final Research Achievements

In recent years, there is a growing interest in a visual cortical prosthetics that delivers muliple electrical stimulations to visual cortex to partially restore visual function in blinds. In order to develop a useful cortical prosthetsis, it is important to assess the effects of electrode distribution implanted in the visual cortex and current intensity delivered from the electrode. In the present study, we studied the effect of current intensity on the cortical activities by imaging resposenes of cortical circuits induced by the current stimulation using rodents. Based on the experiments, we have developed a real time simulation platform, phosphene pattern simulator, to reconstract feasible phosphene patterns induced by the cortical prosthetics. Using the simulator, a subject with normal vision can evaluate the usefulness of phosphene pattern in reading letters, visual navigation and so on by psychophysiacal exeriments.

Academic Significance and Societal Importance of the Research Achievements

本研究は、失明者の視覚機能を部分的にも回復する脳刺激型人工視覚システム開発に関わる重要な意義を持つ。特に人工視覚システムデザインには、視覚野へ埋植する電極の密度や電流強度がどのように光覚イメージを生じさせるかを予測する必要があるが、脳刺激型については研究が進んでいない。本研究では、今回の生理学実験によって得られた結果および過去の脳生理学・解剖学の知見に基づいて、人工視覚によって生じる光覚パターンを予測できる装着可能シミュレータを開発した。このように実験結果を本格的に取り入れたシミュレータは他にない。今後、シミュレータを用いた心理物理実験により、脳刺激型人工視覚システム開発が加速する。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (14 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (10 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results)

  • [Int'l Joint Research] ユーリッヒ研究センター(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] 台湾中央研究院(その他の国・地域)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Focal activation of neuronal circuits induced by microstimulation in the visual cortex2019

    • Author(s)
      Yuta Tanaka, Tomohiro Nomoto, Takuya Shiki, Yuya Sakata, Yoshinori Shimada, Yuki Hayashida, and Tetsuya Yagi
    • Journal Title

      Journal of Neural Engineering, Volume 16, Number 3

      Volume: 16 Issue: 3 Pages: 036007-036007

    • DOI

      10.1088/1741-2552/ab0b80

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age-related changes in the spatiotemporal responses to electrical stimulation in the visual cortex of rats with progressive vision loss2017

    • Author(s)
      S. Miyamoto, N. Suematsu, Y. Umehira , Y. Hayashida, T. Yagi
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 14165-14165

    • DOI

      10.1038/s41598-017-14303-1

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Spatiotemporal Analysis of Simultaneous Repetitive Electrical Stimulation with Voltage Sensitive Dye2018

    • Author(s)
      L. de Levy Oliveira, N. Suematsu, T. Yagi
    • Organizer
      IEEE Biomedical Circuits and Systems 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A neuromorphic retina model that reproduces neuronal images of the retinal circuit in real time2018

    • Author(s)
      Tetsuya Yagi
    • Organizer
      Switch Board European Training Network, Retina Symposium
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Imaging of population spikes induced by repetitive stimulus pulses in mouse cerebral slices in vitro2017

    • Author(s)
      T. Nomoto, Y. Tanaka, Y. Hayashida, T. Yagi
    • Organizer
      Engineering in Medicine and Biology Society
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Wireless Device System for Multi-Channel Intra-Cortical Microstimulations ~Evaluation with Animal Studies in Vivo2017

    • Author(s)
      Y. Hayashida
    • Organizer
      Engineering in Medicine and Biology Society
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] VRハードウェア実装に向けた脳刺激型人工視覚の定式化シミュレーションモデルの検討2017

    • Author(s)
      岸上展章, 崔軫煥, 戸田敦士, 林田祐樹, 八木哲也
    • Organizer
      SICEライフエンジニアリング部門シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] in-vivoマウス視覚野における微小電流刺激に誘発されるシナプス性興奮伝播のメカニズムに関する考察2017

    • Author(s)
      森定慶祐, 柿市峻佑, 末松尚史, 林田祐樹, 八木哲也
    • Organizer
      MEとバイオサイバネティックス研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] 眼球追跡を用いた皮質刺激型人工視覚シミュレータの開発2017

    • Author(s)
      崔 軫煥, 岸上 展章, 戸田 敦士, 林田 祐樹, 八木 哲也
    • Organizer
      MEとバイオサイバネティックス研究会
    • Place of Presentation
      福岡
    • Related Report
      2016 Research-status Report
  • [Presentation] Spatiotemporal excitation of the primary visual cortex induced by intracortical microstimulation in the Royal College of Surgeons rats2016

    • Author(s)
      S. Miyamoto, N. Suematsu, Y. Umehira, Y. Hayashida, T. Yagi
    • Organizer
      Society for Neuroscience 46th Annual Meeting Neuroscience 2016
    • Place of Presentation
      San Diego
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Response profiles of a neuronal population excited by intracorticalmicrostimulations in the mouse visual cortex2016

    • Author(s)
      Naofumi SUEMATSU, Kouki TAKATANI, Yuki HAYASHIDA, Yuka OKAZAKI, andTetsuya YAGI
    • Organizer
      Society for Neuroscience 46th Annual Meeting Neuroscience 2016
    • Place of Presentation
      San Diego
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 膜電位応答イメージングによる皮質内微小電流刺激のパラメータの検討2016

    • Author(s)
      野本 知宏, 田中 雄太, 林田 祐樹, 八木 哲也
    • Organizer
      MEとバイオサイバネティックス研究会
    • Place of Presentation
      大阪
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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