| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Mineralized tissue formation is highly regulated by osteogenic cells in our body. In this project, we examined whether exosomes, which were secreted from cells, involved the mineralization process of osteogenic cells in vitro. We extracted exosomes from culture media of osteogenic and non-osteogenic cells. We found that exosomes had crystal nucleation ability in simulated boy fluid regardless of the type of cells. We further found that exosomes from mesenchymal stem cells contributed mineralized tissue formation. Thus, exosomes are biochemical extracellular regulators for mineralized tissue formation.
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