Development of analyzer based refraction-contrast tomosynthesis device using x-ray tube

• Project/Area Number: 16K01369
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Hokkaido University of Science
• Principal Investigator: Shimao Daisuke 北海道科学大学, 保健医療学部, 教授 (20404907)
• Co-Investigator(Kenkyū-buntansha): 佐藤 斉 茨城県立医療大学, 保健医療学部, 教授 (90285057) ; 砂口 尚輝 名古屋大学, 医学系研究科(保健), 准教授 (60536481)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 医用画像 / X線管 / 屈折コントラスト / トモシンセシス

Outline of Final Research Achievements

Currently, the tomosynthesis based on refraction-contrast is feasible by a large-scale apparatus such as a synchrotron. We tried to put the tomosynthesis mentioned above into practice by X-ray tube, which is much inferior in X-ray output relative to synchrotron toward its spread. It was, however, proven that focus size of industrial X-ray tube available in this study was too large to utilize for a fine X-ray imaging.
Then we rearranged the study and assessed the prospect of this theme by investigating reflection intensity of characteristic X-rays from molybdenum and tungsten target. As a result, it has been clarified that the reflection intensity of characteristic X-rays from tungsten target by symmetric-cut monochrometer was 270 times stronger than that form molybdenum target, which led to the solution of the issue on X-ray intensity.

Academic Significance and Societal Importance of the Research Achievements

屈折コントラストによるトモシンセシスがX線管で実現可能となれば、日常診療の中で軟部組織の断層像が高コントラストで得られるようになり、特に乳がんの画像診断にこれまでにない知見を与え得る。
本研究期間内では焦点サイズの問題のため画像化までは至らずX線管から得られる単色の反射X線の強度特性を明らかにすることにとどまった。しかし、小焦点サイズのもと大出力が可能なX線管が開発されれば、X線管で屈折コントラストによるトモシンセシスの実現が示唆されるものとなった。

Research Products

• [Journal Article] Three-dimensional reconstruction of human nipple using refraction-contrast x-ray computed Tomography (2019)
  • Author(s): Sunaguchi Naoki、Shimao Daisuke、Ichihara Shu、Mori Kensaku、Yuasa Tetsuya、Ando Masami
  • Journal Title: AIP Conference Proceedings Volume: 2054(1) Pages: 050010-050010
  • DOI: 10.1063/1.5084628
  • Peer Reviewed
• [Journal Article] Scanning, registration, and fiber estimation of rabbit hearts using micro-focus and refraction-contrast x-ray CT (2019)
  • Author(s): Hirohisa Oda, Holger R. Roth, Takaaki Sugino, Naoki Sunaguchi, Noriko Usami, Masahiro Oda, Daisuke Shimao, Shu Ichihara, Tetsuya Yuasa, Masami Ando, Toshiaki Akita, Yuji Narita, Kensaku Mori
  • Journal Title: Proc. SPIE Volume: 10953 Pages: 52-52
  • DOI: 10.1117/12.2512145
  • Peer Reviewed
• [Journal Article] Micro-focus X-ray CT of the heart: A comparison with X-ray refraction-contrast CT (2018)
  • Author(s): Hirohisa Oda, Holger R. Roth, Naoki Sunaguchi, Daisuke Shimao, Takaaki Sugino, Masahiro Oda, Toshiaki Akita, Yuji Narita, Shu Ichihara, Tetsuya Yuasa, Masami Ando, Kensaku Mori
  • Journal Title: International Journal of Computer Assisted Radiology and Surgery Volume: 13, Sup.1
  • Peer Reviewed
• [Journal Article] 屈折コントラストX線CT撮像法と病理サンプルの三次元構造解析 (2018)
  • Author(s): 砂口尚輝, 島雄大介, 市原周, 川崎朋範, 森健策, 湯浅哲也, 安藤正海
  • Journal Title: Medical Imaging Technology Volume: 36 Pages: 107-113
  • NAID: 130007384469
• [Journal Article] X 線暗視野法利用医用画像の開発 (2018)
  • Author(s): 安藤正海, 島雄大介, 砂口尚輝, 湯浅哲也, 森健策, マクシメンコ アントン, 市原周, グプタ ラジーフ
  • Journal Title: 放射光 Volume: 31 Pages: 10-21
  • NAID: 40021470336
  • Peer Reviewed
• [Journal Article] Imaging with ultra-small-angle X-ray scattering using a Laue-case analyzer and its application to human breast tumors (2017)
  • Author(s): Daisuke Shimao, Naoki Sunaguchi, Tenta Sasaya, Tetsuya Yuasa, Shu Ichihara,Tomonori Kawasaki, Masami Ando
  • Journal Title: Physica Medica Volume: 44 Pages: 236-242
  • DOI: 10.1016/j.ejmp.2017.10.018
  • Peer Reviewed
• [Journal Article] Dark-Field Imaging: Recent developments and potential clinical (2016)
  • Author(s): M. Ando, N. Sunaguchi , D. Shimao, A. Pan, T. Yuasa , K. Mori, Y. Suzuki, G. Jin, J. K. Kim, J. H. Lim, S. J. Seo, S. Ichihara, N. Ohura, R. Gupta
  • Journal Title: Physica Medica Volume: 32 Issue: 12 Pages: 1801-1812
  • DOI: 10.1016/j.ejmp.2016.11.103
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 屈折コントラストCTを用いたヒト乳頭組織内における乳管構造の解析 (2019)
  • Author(s): 砂口尚輝, 島雄大介, 市原周, 西村理恵子, 湯 哲也, 森健策, 安藤正海
  • Organizer: 第32回日本放射光学会年会・放射光科学合同シンポジウム
• [Presentation] BL8S2を利用した生体組織の屈折コントラストCT撮像実験 (2019)
  • Author(s): 砂口尚輝, 島雄大介, 桜井郁也, 花田賢志, 池野成裕, 東博純, 市原周
  • Organizer: 第8回名古屋大学シンクロトロン光研究センターシンポジウム
• [Presentation] 屈折コントラストCT を用いた非浸潤性乳管癌篩状構造の観察 (2019)
  • Author(s): 砂口尚輝, 黄 卓然, 島雄大介, 市原周, 西村理恵子, 湯浅哲也, 安藤正海
  • Organizer: 量子ビームサイエンスフェスタ2018
• [Presentation] Development of a laboratory based refraction-contrast imaging system using industrial x-ray tube (2018)
  • Author(s): Daisuke Shimao, Erika Nakajima, Hitoshi Sato
  • Organizer: World Congress on Medical Physics and Biomedical Engineering (WC2018)
  • Int'l Joint Research
• [Presentation] 3D High-Resolution Microstructure Imaging of the Heart (2018)
  • Author(s): Hirohisa Oda, Holger R. Roth, Naoki Sunaguchi, Tetsuya Yuasa, Toshiaki Akita, Kensaku Mori, Daisuke Shimao, Shu Ichihara, Masami Ando, Noriko Usami, Masahiro Oda, Yuji Narita
  • Organizer: Radiological Society of North America（RSNA）2018
  • Int'l Joint Research
• [Presentation] ウサギ心臓の屈折CT像における線維配向の可視化ならびに評価 (2018)
  • Author(s): 小田紘久, Holger R. Roth, 砂口尚輝, 宇佐美紀子, 小田昌宏 , 島雄大介, 市原周, 湯浅哲也, 安藤正海, 秋田利明, 成田裕司, 森健策
  • Organizer: 第37回日本医用画像工学会大会（JAMIT2018)
• [Presentation] Sparse annotationによる深層学習ベースの解剖構造抽出：屈折X線CT像からの精密な眼球セグメンテーション (2018)
  • Author(s): 杉野貴明, Holger R. Roth, 小田昌宏, 砂口尚輝, 島雄大介, 市原周, 湯浅哲也, 安藤正海, 森健策
  • Organizer: 第21回 画像の認識・理解シンポジウム（MIRU2018）
• [Presentation] 屈折コントラストCTによるヒト乳頭組織の3次元解析 (2018)
  • Author(s): 砂口尚輝, 島雄大介, 市原周, 西村理恵子, 湯浅哲也, 森健策, 安藤正海
  • Organizer: 第35回センシングフォーラム 計測部門大会
• [Presentation] 層学習を用いた屈折 X 線 CT 画像からの眼球構造抽出 ―Sparse annnotation データの学習法に関する検討― (2018)
  • Author(s): 杉野貴明, Holger R. Roth, 小田昌宏, 砂口尚輝, 島雄大介, 森健策
  • Organizer: 第27回日本コンピュータ外科学会大会
• [Presentation] Technical Aspect of X-ray Dark-Field Imaging (2017)
  • Author(s): M. Ando, A. Badrutdinov, K. Deasy, R. Gupta, Y. Higashi, K. Hyodo, S. Ichihara, Ge Jin, J.-K. Kim, G. Li K. Mori S.-J. Seo, D. Shimao, Y. Sun, N. Sunaguchi, Y. Suzuki, T. Yuasa
  • Organizer: The 12th Asian Meeting on Synchrotron Biomedical Imaging
  • Int'l Joint Research
• [Presentation] Ultra-small angle x-ray scattering imaging of breast specimens using Laue case analyzer (2017)
  • Author(s): D. Shimao, N. Subaguchi, T. Sasaya, T. Yuasa, S. Ichihara, T. Kawasaki, M. Ando
  • Organizer: The 12th Asian Meeting on Synchrotron Biomedical Imaging
  • Int'l Joint Research
• [Presentation] Impact of crystal analyser-based phase contrast X-ray computed tomography on histopathology (2017)
  • Author(s): S. Ichihara, T. Kawasaki, N. Sunaguchi, D. Shimao, T. Yuasa, K. Mori, M. Ando, R. Gupta
  • Organizer: 29th European Congress of Pathology
  • Int'l Joint Research
• [Presentation] DEVELOPMENT OF IN-LINE HOLOGRAPHIC PHASE-CONTRAST IMAGING SYSTEM USING INDUSTRIAL X-RAY SYSTEM (2017)
  • Author(s): D. Shimao, E. Nakajima, H. Sato
  • Organizer: 17th Asia Oceania Congress of Medical Physics
  • Int'l Joint Research
• [Presentation] 3D Microstructure Visualization of Lactiferous Duct Structure Based On Refraction X-Ray CT Imaging (2017)
  • Author(s): K. Mori, N. Sunaguchi, M. Ando, T. Yuasa, D. Shimao, S. Ichihara, R. Gupta
  • Organizer: Radiological Society of North America（RSNA）
  • Int'l Joint Research
• [Presentation] Development of an ultra-samll angle x-ray scattering imaging using Laue case analyzer (2016)
  • Author(s): D. Shimao, N. Sunaguchi, T. Yuasa, S. Ichihara
  • Organizer: The 22nd International Conference on Medical Physics
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2016-12-09
  • Int'l Joint Research
• [Presentation] Refraction-contrast tomosynthesis and ultra-small angle X-ray scattering imaging of a breast specimen using Laue case analyzer (2016)
  • Author(s): D. Shimao, N. Sunaguchi, T. Yuasa, S. Ichihara, M. Ando
  • Organizer: The 11th Asian Meeting on Synchrotron Radiation Biomedical Imaging
  • Place of Presentation: PyeongChang, Korea
  • Year and Date: 2016-10-07
  • Int'l Joint Research
• [Presentation] Recent Attempt at Achieving Higher Spatial Resolution in X-ray Dark-Field Imaging for Histo-Pathological Applications (2016)
  • Author(s): M. Ando, N. Sunaguchi, D. Shimao, T. Yuasa, K. Mori, Y. Suzuki, G. Jin, J. K. Kim, S. J. Seo, S. Ichihara, N. Ohura, R. Gupta, J. H. Lim
  • Organizer: The 11th Asian Meeting on Synchrotron Radiation Biomedical Imaging
  • Place of Presentation: PyeongChang, Korea
  • Year and Date: 2016-10-07
  • Int'l Joint Research
• [Book] Synchrotron Radiation Applications (Crystal-based X-ray Medical Imaging Using Synchrotron Radiation and Its Future Prospect) (2018)
  • Author(s): Masami Ando, Naoki Sunaguchi, Yongjin Sung, Daisuke Shimao, Jong-Ki Kim, Gang Li, Yoshifumi Suzuki, Tetsuya Yuasa, Kensaku Mori, Shu Ichihara and Rajiv Gupta
  • Total Pages: 668
  • Publisher: World Scientific
  • ISBN: 9789813227668