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Identification of nonalcoholic steatohepatitis and risk assessment of cancer development by using acoustic investigation

Research Project

Project/Area Number 16K01406
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical systems
Research InstitutionChiba University

Principal Investigator

MARUYAMA Hitoshi  千葉大学, 大学院医学研究院, 講師 (90375642)

Co-Investigator(Kenkyū-buntansha) 清野 宗一郎  千葉大学, 医学部附属病院, 医員 (00773326)
山口 匡  千葉大学, フロンティア医工学センター, 教授 (40334172)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords肝臓 / 超音波 / 脂肪酸 / 脂肪肝 / インピーダンス
Outline of Final Research Achievements

Fatty liver disease is increasing worldwide, and nonalcoholic steatohepatitis (NASH) may be one of the most important treatment-resistive liver diseases. This project demonstrated the acoustic properties of NASH by comparing those of simple steatosis and control in the animal model and human subjects. The assessment using 80/250MHz transducer identified higher acoustic impedance in simple steatosis, and lower acoustic impedance in NASH as characteristic features. Also, lower impedance in the non-tumor liver tissue may feature a risk of cancer development in NASH. These acoustic properties were based on the intrahepatic composition of fatty acid which showed characteristic property in itself. These data may enhance the quality of noninvasive diagnosis of NASH and the risk stratification of cancer development.

Academic Significance and Societal Importance of the Research Achievements

本課題の成果は、実臨床における脂肪関連肝疾患の診断と発癌リスク患者の囲い込みに極めて有用である。すなわち、単純性脂肪肝とNASHの鑑別において不要な肝組織生検検査を回避することが可能となり、発癌高危険群に対しては相応の診療を提供することができる。今後の急増が予想されるNASHに対して、脂肪酸マッピングを基盤とした超音波という非侵襲的な手法を応用することで、健診・検診の質や患者診療体制を飛躍的に向上させる研究成果である。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (26 results)

All 2019 2018 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (20 results) (of which Int'l Joint Research: 8 results,  Invited: 8 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Advances in ultrasound diagnosis in chronic liver diseases2019

    • Author(s)
      Maruyama H, Kato N
    • Journal Title

      Clin Mol Hepatol

      Volume: - Issue: 2 Pages: 160-167

    • DOI

      10.3350/cmh.2018.1013

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proposal of compound amplitude envelope statistical analysis model considering low scatterer concentration2018

    • Author(s)
      Tamura K, Yoshida K, Maruyama H, Hachiya H, Yamaguchi M
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 印刷中

    • NAID

      210000149318

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Asian-Pasific Association for the study of the liver (APASL) consensus guidelines in invasive and non-invasive assessment of hepatic fibrosis: A 2016 update2017

    • Author(s)
      Shiha G, Ibrahim A, Helmy A, Sarin SK, Omata M, Kumar A, Bernstien D, Maruyama H, et al
    • Journal Title

      Hepatology International

      Volume: 11 Issue: 1 Pages: 1-30

    • DOI

      10.1007/s12072-016-9760-3

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Acoustic impedance analysis with high-frequency ultrasound for identification of fatty acid species in the liver2017

    • Author(s)
      Kazuyo Ito, Kenji Yoshida, Hitoshi Maruyama, Jonathan Mamou, Tadashi Yamaguchi
    • Journal Title

      Ultrasound in Medicine and Biology

      Volume: 43 Issue: 3 Pages: 700-711

    • DOI

      10.1016/j.ultrasmedbio.2016.11.011

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Suppression of IGF binding protein-3 by palmitate promotes hepatic inflammatory responses2016

    • Author(s)
      Min HK, Maruyama H, Jang BK, Shimada M, Mirshahi F, Ren S, Oh Y, Puri P, Sanyal AJ
    • Journal Title

      FASEB Journal

      Volume: 30 Issue: 12 Pages: 4071-4082

    • DOI

      10.1096/fj.201600427r

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 脂肪酸の音響特性解析による肝臓内の組織構造評価2018

    • Author(s)
      伊藤一陽,本田瑶季,吉田憲司,丸山紀史,山口 匡
    • Organizer
      日本超音波医学会第91回学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 血中microRNA-200bの非アルコール性脂肪肝疾患における肝線維化指標としての有用性に関する検討2018

    • Author(s)
      中村昌人、丸山紀史、加藤直也
    • Organizer
      第54回日本肝臓学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Advances in Ultrasound Diagnosis for Chronic Liver Diseases and Beyond2018

    • Author(s)
      Hitoshi Maruyama
    • Organizer
      Liver Week (Korea)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Portal Hypertension and Ultrasound2018

    • Author(s)
      Hitoshi Maruyama
    • Organizer
      CHESS meeting
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Loss of Locomotion Is a Risk of Non-Alcoholic Fatty Liver Disease2018

    • Author(s)
      Kanayama K, Nakagawa R, Kanzaki H, Maeda T, Kojima R, Kobayashi K, Kiyono S, Nakamura M, Ogasawara S, Suzuki E, Nakamoto S, Muroyama R, Yasui S, Ooka Y, Chiba T, Maruyama H, Moriyama M, Nakagawa T, and Kato N
    • Organizer
      American Association for the Study of Liver Diseases
    • Related Report
      2018 Annual Research Report
  • [Presentation] The use of Interventional Ultrasound in Diagnosis and Treatment of Liver Disorders2017

    • Author(s)
      Hitoshi Maruyama
    • Organizer
      The 4th Liver-GI Fair
    • Place of Presentation
      Shangri-La Hotel, Jakarta, Indonesia
    • Year and Date
      2017-03-18
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Ultrasound-guided PTBD2017

    • Author(s)
      Hitoshi Maruyama
    • Organizer
      The 4th Liver-GI Fair
    • Place of Presentation
      Shangri-La Hotel, Jakarta, Indonesia
    • Year and Date
      2017-03-18
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Innovation of Advanced Diagnostic Ultrasound:Development and Technique2017

    • Author(s)
      Hitoshi Maruyama
    • Organizer
      The 4th Liver-GI Fair
    • Place of Presentation
      Shangri-La Hotel, Jakarta, Indonesia
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] HCC Diagnosis and Therapy using Advanced Ultrasound Technique2017

    • Author(s)
      Hitoshi Maruyama
    • Organizer
      The 4th Liver-GI Fair
    • Place of Presentation
      Shangri-La Hotel, Jakarta, Indonesia
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 臨床からみた門脈圧亢進症の病態分析2017

    • Author(s)
      丸山紀史
    • Organizer
      第36回日本画像医学会
    • Place of Presentation
      ステーションコンファレンス東京 (東京都、千代田区)
    • Year and Date
      2017-02-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 肝血流からみた脂肪肝とアルコール性肝疾患の病態2017

    • Author(s)
      丸山紀史
    • Organizer
      第36回アルコール医学生物学研究会学術集会
    • Place of Presentation
      新横浜プリンスホテル (神奈川県、横浜市)
    • Year and Date
      2017-01-27
    • Related Report
      2016 Research-status Report
  • [Presentation] Inhibition of microRNA-b/c improved liver inflammation and liver fibrosis in NASH model mice2017

    • Author(s)
      Nakamura M, Kanda T, Nakamoto S, Wu S, Yasui S, Maruyama H, Kato N
    • Organizer
      American Association for the Study of Liver Diseases 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Role of microbubble-based contrast-enhanced ultrasound for the assessment of portal hypertension2017

    • Author(s)
      Maruyama H
    • Organizer
      16th World Federation for Ultrasound in Medicine and Biology Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Speed of Sound Evaluation of Organelles of NASH Livers in rats with 250-MHz Ultrasound2017

    • Author(s)
      Ito K, Yoshida K, Mamou J, Maruyama H, Yamaguchi T
    • Organizer
      2017 IEEE International Ultrasonics Symposium
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 500MHz超音波を用いた軟組織の音響特性評価2017

    • Author(s)
      伊藤一陽,田村和輝,丸山紀史,吉田憲司,山口 匡
    • Organizer
      日本超音波医学会第90回学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 肝臓内の脂肪酸種特定に向けた音響物性解析2017

    • Author(s)
      徳永 栞,伊藤一陽,丸山紀史,吉田憲司,山口 匡
    • Organizer
      日本超音波医学会第90回学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Non-cirrhotic portal hypertension “Eastern Prospective”2016

    • Author(s)
      Hitoshi Maruyama
    • Organizer
      The Liver Meeting 2016, American Association for the Study of Liver Diseases
    • Place of Presentation
      John B. Hynes Veterans Memorial Convention Center, Boston, USA
    • Year and Date
      2016-11-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 摘出ラット肝臓を用いた散乱体サイズ推定法の精度検証2016

    • Author(s)
      鳥井亮汰,田村和輝,吉田憲司,丸山紀史,長谷川英之,山口 匡
    • Organizer
      日本超音波医学会第28回関東甲信越地方会学術集会
    • Place of Presentation
      東京ファッションタウン (東京都、江東区)
    • Year and Date
      2016-10-22
    • Related Report
      2016 Research-status Report
  • [Presentation] マウス肝臓内における脂肪および線維の音響インピーダンス解析2016

    • Author(s)
      伊藤一陽,吉田憲司,丸山紀史,山口 匡
    • Organizer
      日本超音波医学会第89回学術集会
    • Place of Presentation
      国立京都国際会館 (京都府、京都市)
    • Year and Date
      2016-05-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 病変モデルラット肝臓を用いた組織弾性と音響特性の関係性の検討2016

    • Author(s)
      村上顕央,吉田憲司,岸本理和,小畠隆行,丸山紀史,山口 匡
    • Organizer
      日本超音波医学会第89回学術集会
    • Place of Presentation
      国立京都国際会館 (京都府、京都市)
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] 脂肪酸種推定方法及び脂肪酸種推定プログラム2016

    • Inventor(s)
      山口匡,吉田憲司,伊藤一陽,丸山紀史
    • Industrial Property Rights Holder
      山口匡,吉田憲司,伊藤一陽,丸山紀史
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-10-28
    • Related Report
      2016 Research-status Report
    • Overseas

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Published: 2016-04-21   Modified: 2020-03-30  

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