Estimation of patient-specific muscle fiber arrangement using clinical CT and statistical modeling of the fiber arrangement
| Project/Area Number |
16K01411
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
OTAKE Yoshito 奈良先端科学技術大学院大学, 先端科学技術研究科, 准教授 (80349563)
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| Co-Investigator(Kenkyū-buntansha) |
高尾 正樹 大阪大学, 医学系研究科, 講師 (30528253)
横田 太 奈良先端科学技術大学院大学, 先端科学技術研究科, 助教 (60759900)
SOUFI MAZEN 奈良先端科学技術大学院大学, 先端科学技術研究科, 助教 (80823525)
菅野 伸彦 大阪大学, 医学系研究科, 寄附講座教授 (70273620)
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| Research Collaborator |
SATO Yoshinobu
TAKAGI Shu
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 生体シミュレーション / 筋骨格力学解析 / 筋線維走行モデリング / バイオメカニクス解析 / 筋線維モデリング / 医用画像解析 / CT画像 / 筋骨格セグメンテーション / 線維走行統計モデル / 医用システム / コンピュータ外科 |
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| Outline of Final Research Achievements |
We aimed at in-vivo measurement of muscle fiber arrangement in skeletal muscles from patient-specific CT. Conventionally, the in-vivo muscle fiber analysis is limited to diffusion tensor MRI and ultrasound images. This study explored a third method using CT in order to allow much larger field-of-view and apply to broader clinical applications. We created a high-fidelity 3D muscle fiber template from cryo-section images derived from cadavers. Then, we developed a robust registration algorithm that non-rigidly register the template to CT images to estimate the patient-specific muscle fiber arrangement. The estimated results were quantitatively evaluated by CT image of the cadaver. The developed algorithm was applied to a large-scale database of clinical CT and variation in the muscle fiber arrangements was analyzed. The muscle fiber arrangements can be applied in biomechanical simulation in orthopedic surgery, rehabilitation medicine, as well as ergonomic design in industry, and so on.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は臨床用CTから、従来の解析対象より一段階微細な構造である「筋線維束」の抽出に挑戦した。遺体から作製した信頼性の高い三次元線維走行モデルを事前知識として用いる事で、ノイズの多いCT画像から安定な線維走行解析を可能とした。ここで得られた被験者個別の筋線維走行を反映した次世代骨格筋モデルによる力学シミュレーションは、整形外科や歯科、スポーツ医学におけるバイオメカニクス解析へ応用可能である。また、人間工学を考慮したデザインや自動車の衝突による人体へのダメージの解析など、様々な産業分野でも、生体シミュレーションは中核をなす基礎科学でありこれらの分野への波及効果も期待できる。
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Estimation of attachment regions of hip muscles in CT image using muscle attachment probabilistic atlas constructed from measurements in eight cadavers2017
Author(s)
Fukuda N, Otake Y, Takao M, Yokota F, Ogawa T, Uemura K, Nakaya R, Tamura K, Grupp RB, Farvardin A, Armand M
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Journal Title
International Journal of Computer Assisted Radiology and Surgery
Volume: -
Issue: 5
Pages: 1-10
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Cross-Modality Image Synthesis from Unpaired Data Using CycleGAN2018
Author(s)
Yuta Hiasa, Yoshito Otake, Masaki Takao, Takumi Matsuoka, Kazuma Takashima, Aaron Carass, Jerry L Prince, Nobuhiko Sugano, Yoshinobu Sato
Organizer
21th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI) International Workshop on Simulation and Synthesis in Medical Imaging
Related Report
Int'l Joint Research
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[Presentation] Reconstruction of 3D muscle fiber structure using high resolution cryosectioned volume2017
Author(s)
Yoshito Otake, Kohei Miyamoto, Axel Olliver, Futoshi Yokota, Norio Fukuda, Lauren J. O’Donnell, Carl-Fredric Westin, Masaki Takao, Nobuhiko Sugano, Beom Sun Chung, Jin Seo Park, Yoshinobu Sato
Organizer
20th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI)
Related Report
Int'l Joint Research
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[Presentation] Reconstruction of patient-specific fiber arrangement of skeletal muscles from clinical CT2017
Author(s)
Yoshito Otake, Futoshi Yokota, Norio Fukuda, Masaki Takao, Shu Takagi, Naoto Yamamura, Lauren J. O’Donnell, Carl-Fredrik Westin, Min Suk Chung, Nobuhiko Sugano, Yoshinobu Sato
Organizer
Computer Assisted Radiology and Surgery
Related Report
Int'l Joint Research
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[Presentation] 8体のCadaverによる実計測を用いた股関節筋付着部位の統計的予測2016
Author(s)
福田紀生, 大竹義人, 高尾正樹, 横田太, 小川剛, 上村圭亮, 中矢亮太, 田村和則, Robert Grupp, Amirhossein Farvardin, Mehran Armand, 菅野伸彦, 佐藤嘉伸
Organizer
第35回日本医用画像工学会大会
Place of Presentation
千葉大学（千葉県千葉市）
Year and Date
2016-07-21
Related Report
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[Presentation] Statistical Estimation of Attachment of Hip Muscles Based on Measurement in Cadavers2016
Author(s)
Norio Fukuda, Yoshito Otake, Masaki Takao, Futoshi Yokota, Takeshi Ogawa, Keisuke Uemura, Ryota Nakaya, Kazunori Tamura,Robert Grupp, Amirhossein Farvardin, Mehran Armand, Nobuhiko Sugano,Yoshinobu Sato
Organizer
The 16th Annual Meeting of the International Society for Computer Assisted Orthopedic Surgery
Place of Presentation
Congress Convention Center (Osakashi, Osaka)
Year and Date
2016-06-08
Related Report
Int'l Joint Research
