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Prognostic value in tissue characterization of carotid plaque using iPlaque software

Research Project

Project/Area Number 16K01412
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical systems
Research InstitutionThe University of Tokushima

Principal Investigator

YAMADA Hirotsugu  徳島大学, 大学院医歯薬学研究部(医学域), 特任教授 (40380084)

Co-Investigator(Kenkyū-buntansha) 天野 里江  徳島大学, 病院, 診療放射線技師 (90749011)
鳥居 裕太  徳島大学, 病院, 臨床検査技師 (10748130)
平田 有紀奈  徳島大学, 病院, 臨床検査技師 (90747817)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords脳梗塞 / 頸動脈プラーク / 超音波組織診断 / プラーク脆弱性 / 脳卒中 / 超音波検査 / 超音波組織性状 / iPlaque / 動脈硬化 / 組織性状評価 / 頸動脈硬化症 / 頸動脈超音波検査 / 心血管イベント / 不安定プラーク / 超音波診断装置 / 組織性状 / 動脈硬化疾患 / 予後
Outline of Final Research Achievements

The characteristics of carotid plaques that can be observed by carotid ultrasonography may be associated with the onset of cerebral infarction and myocardial infarction. We developed a iPlaque software which enables tissue characterization of carotid plaques using carotid ultrasonography.
Percentage of fatty area of carotid plaque analysed by our iPlaque software was greater in patients with symptomatic stroke patients than in patients with non-symptomatic patients.
In a lifestyle-related disease patient at risk of arteriosclerosis, whether the ultrasonic properties of the carotid plaque quantified using iPlaque can predict future event onset is being analyzed and will be reported later.

Academic Significance and Societal Importance of the Research Achievements

頸動脈プラークの組織性状が,発症の予測が困難な脳梗塞や心筋梗塞と関連することが知られている.研究代表者のグループは,超音波検査を用いて非侵襲的に頸動脈プラークの組織性状を定量化することができるiPlaqueソフトウェアを開発した.本ソフトウェアを用いて,脳梗塞患者の頸動脈プラークを定量的に評価したところ有症候例で脂質成分の比率が高いことが判明した.したがって,動脈硬化のリスクを持つ患者の頸動脈プラークを本ソフトウェアで観察することで,プラークの脆弱性を判断することができ,脆弱性が高い例において治療を強化することで,将来の脳梗塞を予防できる可能性がある.

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (6 results)

All 2019 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Comparison of Ultrasonographic Indices to Reflect Renal Functional Impairment in Diabetic Nephropathy Patients2019

    • Author(s)
      松本 力三、山田 博胤、佐田 政隆、西尾 進、平田 有紀奈、湯浅 麻美、鳥居 裕太、天野 里江、山尾 雅美、荒瀬 美晴、楠瀬 賢也
    • Journal Title

      Japanese Journal of Medical Ultrasound Technology

      Volume: 44 Issue: 4 Pages: 447-455

    • DOI

      10.11272/jss.288

    • NAID

      130007690583

    • ISSN
      1881-4506, 1881-4514
    • Year and Date
      2019-08-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] 糖尿病性腎症の各病期における超音波像の比較2018

    • Author(s)
      松本力三,西尾進,鳥居裕太,平田有紀奈,天野里江,山尾雅美,楠瀬賢也,山田博胤,佐田政隆
    • Organizer
      第43回日本超音波検査学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 頸動脈と心エコーのコラボレーション(両者を合わせることが有用な病態)2017

    • Author(s)
      西尾 進,山田博胤
    • Organizer
      日本超音波医学会 第90回学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 頸動脈内膜中膜複合体厚にDPP4阻害薬シタグリプチンが及ぼす影響2017

    • Author(s)
      天野里江,平田友紀奈,鳥居裕太,山田博胤
    • Organizer
      第65回日本心臓病学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Change in Ultrasonic Tissue Characteristics of Carotid Artery Plaque Reflects That of Coronary Artery Plaque2017

    • Author(s)
      坂東美佳,山田博胤
    • Organizer
      Euro Echo Imaging 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Quantitative Ultrasound Evaluation of the Changes on Tissue Characteristics of Carotid Plaques by Lipid Lowering2016

    • Author(s)
      Rie Amano
    • Organizer
      27th America Society of Echocardiography
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2016-06-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2021-02-19  

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