Study of pathophysiology of musculoskeletal chronic pain : search for biomarkers by young age specificity

• Project/Area Number: 16K01472
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Tokoha University
• Principal Investigator: SAKURAI Hiroki 常葉大学, 保健医療学部, 准教授 (60454419)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 慢性痛 / 運動器 / 生後発達 / 若齢 / リハビリテーション

Outline of Final Research Achievements

Clinically, it is known that the incidence of chronic pain is much lower in children than in adults. The low-incidence may disclose some important factors to develop chronic pain in the adulthood. In this study, we treated to the young rat in the musculoskeletal chronic pain model procedure we have developed. The treatment to adult rats produced long-persisting pain behaviors, on the contrary, the treatment to young rats did not develop chronic pain behaviors. In damaged skeletal muscle, time course of recovery observed almost same between young and adult rat. Though, the expression level of myogenin in muscle and spinal cord were different in chronic phase. These results suggest that muscle developmental factor coordinate the pathogenesis of musculoskeletal chronic pain.

Academic Significance and Societal Importance of the Research Achievements

運動器障害をはじめとした神経損傷以外の原因で発症する慢性痛は、病態が複雑で治療法、リハビリテーションが構築されておらず、ADL、QOLの低下を引き起こし、社会的に大きな問題となっている。ここに筋の回復過程に注目していくことで、運動器慢性痛のメカニズムの解明と効果的な慢性痛リハビリテーションの基礎の構築につながることが期待される。

Research Products

• [Journal Article] 運動器慢性痛治療における運動療法の診療への組み込み (2018)
  • Author(s): 櫻井博紀
  • Journal Title: 日本運動器疼痛学会ニュースレター Volume: 1 Pages: 3-4
• [Journal Article] 筋・筋膜性疼痛 (2017)
  • Author(s): 泉仁，葛西雄介，櫻井博紀
  • Journal Title: 脊椎脊髄ジャーナル Volume: 30 Pages: 633-637
• [Presentation] 運動療法のup to date (2019)
  • Author(s): 櫻井博紀, 牛田享宏, 井上真輔, 西原真理, 新井健一, 佐藤純, 尾張慶子, 西須大徳, 牧野泉, 井上雅之,下和弘
  • Organizer: 第48回日本慢性疼痛学会
• [Presentation] 筋痛・筋圧痛の病態を探る (2016)
  • Author(s): 櫻井博紀
  • Organizer: 第38回日本疼痛学会
  • Place of Presentation: 北海道立道民活動センター かでる2・7
  • Year and Date: 2016-06-24