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Development of passive physiological stimulation for mitochondrial dysfunction on skeletal muscle in internal impediment

Research Project

Project/Area Number 16K01505
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionHiroshima University

Principal Investigator

Fujita Naoto  広島大学, 医系科学研究科(保), 講師 (90584178)

Co-Investigator(Kenkyū-buntansha) 藤野 英己  神戸大学, 保健学研究科, 教授 (20278998)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords2型糖尿病 / 高気圧処置 / 耐糖能 / インスリン感受性 / 骨格筋 / 脂肪組織 / サイトカイン / 高気圧 / 炎症性サイトカイン / 高血糖症 / 高インスリン血症 / 肥満 / 高トリアシルグリセロール血症 / 高気圧・高濃度酸素 / 骨格筋ミトコンドリア機能障害 / 内部障害 / 物理的刺激
Outline of Final Research Achievements

The purpose of this study was to investigate the influences of regular hyperbaric treatment as passive physiological stimulation on glucose tolerance in type 2 diabetes with obesity. Glucose tolerance and insulin sensitivity were significantly higher in the diabetic rats treated with 1.3 ATA than the untreated diabetic rats. Hyperbaric treatment also increased IL-10 expression in skeletal muscle and decreased TNFα expression in adipose tissue. These results suggested that TNFα downregulation and IL-10 upregulation in diabetic rats subjected to hyperbaric treatment participate in the crosstalk between adipose and skeletal muscle tissue and improve glucose intolerance. Nevertheless, it had no efficacy for obesity or hyperlipidemia. Further research is required to elucidate the mode of action of hyperbaric treatment in type 2 diabetes with obesity.

Academic Significance and Societal Importance of the Research Achievements

2型糖尿病に対する高気圧処置の有効性はこれまでにも報告されているが、その機序は未だ不明であった。よって、本成果の学術的な意義は、高気圧処置による耐糖能やインスリン感受性の向上に、骨格筋の抗炎症作用、並びに脂肪組織における炎症の軽減が関与している可能性を示した点である。また、現在、2型糖尿病に対するリハビリテーションは運動が主であるが、当該患者が、長期間、積極的に運動を継続するのは困難であり、非現実的である。よって、2型糖尿病などの内部障害患者にとって遂行が安全かつ容易である受動的な介入を確立し、その具体的なプロトコルや適応の確立を図る点が、本成果の社会的意義である。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (19 results)

All 2018 2017 2016 Other

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (14 results) (of which Int'l Joint Research: 4 results) Remarks (2 results)

  • [Journal Article] Oxygen therapy may worsen the survival rate in rats with monocrotaline-induced pulmonary arterial hypertension2018

    • Author(s)
      Fujita Naoto、Yamasaki Natsuki、Eto Kanako、Asaeda Makoto、Kuwahara Wataru、Imagita Hidetaka
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 9 Pages: e0204254-e0204254

    • DOI

      10.1371/journal.pone.0204254

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Changes in lipid metabolism and capillary density of the skeletal muscle following low-intensity exercise training in a rat model of obesity with hyperinsulinemia2018

    • Author(s)
      Fujita Naoto、Aono Saki、Karasaki Kohei、Sera Fumi、Kurose Tomoyuki、Fujino Hidemi、Urakawa Susumu
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 5 Pages: e0196895-e0196895

    • DOI

      10.1371/journal.pone.0196895

    • NAID

      120006488445

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute influence of mild hyperbaric oxygen at 1.25 atmospheres absolute with normal air on mitochondrial enzymes and PGC-1α mRNA levels in rat skeletal muscle2016

    • Author(s)
      Naoto Fujita, Tomoka Tomioka, Miharu Ono, Masataka Deie
    • Journal Title

      Biomedical Research and Clinical Practice

      Volume: 1 Issue: 2 Pages: 42-45

    • DOI

      10.15761/brcp.1000109

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 軽度な高気圧環境への暴露がOLETF ラット の骨格筋特性に及ぼす影響2018

    • Author(s)
      藤田直人、後藤夏季、中村智哉、二井野渉、浦川将
    • Organizer
      第73 回日本体力医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 空気加圧による1.3 気 圧の高気圧処置がOLETF ラットの糖代謝と骨格筋血流量に与える影響2018

    • Author(s)
      後藤夏季、藤田直人、二井野渉、中村智哉、越智亮介、西条寿夫、浦川将
    • Organizer
      第73 回日本体力医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Hyperbaric treatment at 1.3 atmospheres absolute with normal air improves glucose tolerance in type 2 diabetes2018

    • Author(s)
      Natsuki Goto, Naoto Fujita, Wataru Nino, Ryosuke Ochi, Hisao Nisijo, Susumu Urakawa
    • Organizer
      The 5th International Scientific Conference on Occupational and Environmental Health. Hanoi. Vietnam.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effects of enriched environment from weaning to adolescence period on anxiety-like behavior in rats2018

    • Author(s)
      Ryosuke Ochi, Naoto Fujita, Natsuki Goto, Hiroshi Nishimaru, Jumpei Matsumoto, Hisao Nishijo, Susumu Urakawa
    • Organizer
      The 5th International Scientific Conference on Occupational and Environmental Health
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 2 型糖尿用モデルラットの不安 様行動と扁桃体基底外側核の介在ニューロンとの関連2018

    • Author(s)
      越智亮介,藤田直人,渡部芳美,後藤夏季,西条寿夫,浦川将
    • Organizer
      第8 回日本情動学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Parvalbumin positive neurons in the basolateral amygdala and anxiety-like behavior in OLETF rats2018

    • Author(s)
      Ryosuke Ochi, Naoto Fujita, Natsuki Goto, Hisao Nishijo, Susumu Urakawa
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Sciences Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hemodynamic responses to hyperbaric treatment in skeletal muscle of obesity and type 2 diabetes rats2018

    • Author(s)
      Natsuki Goto, Naoto Fujita, Wataru Nino, Kazuyoshi Hisatsune, Ryosuke Ochi, Hisao Nishijo, Susumu Urakawa
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Sciences Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 持久運動が高インスリン血症を伴う肥満の脂質代謝に及ぼす影響2018

    • Author(s)
      藤田 直人, 青野 沙紀, 唐崎 航平, 世羅 布実, 黒瀬 智之, 藤野 英己, 浦川 将
    • Organizer
      第70回日本体力医学会大会(松山)
    • Related Report
      2017 Research-status Report
  • [Presentation] 持久運動が高インスリン血症を伴う肥満の脂質代謝と骨格筋内毛細血管に及ぼす影響2018

    • Author(s)
      藤田 直人, 青野 沙紀, 唐崎 航平, 世羅 布実, 黒瀬 智之, 藤野 英己, 浦川 将
    • Organizer
      第69回日本生理学会中国・四国地方会(徳島)
    • Related Report
      2017 Research-status Report
  • [Presentation] 空気加圧による1.3気圧処置が肥満を伴う2型糖尿病モデルラットの血糖値と内臓脂肪量に与える影響2018

    • Author(s)
      後藤夏季, 藤田直人, 中村智哉, 二井野渉, 越智亮介, 浦川将
    • Organizer
      第29回広島スポーツ医学研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] OLETFラットの病期の進行に伴う骨格筋内毛細血管密度の変化2018

    • Author(s)
      藤田直人, 後藤夏季, 中村智哉, 二井野渉, 越智亮介, 浦川将
    • Organizer
      第123回日本解剖学会全国学術集会(東京)
    • Related Report
      2017 Research-status Report
  • [Presentation] Effects of hyperbaric treatment at 1.3 atmospheres absolute on hyperglycemia and hyperinsulinemia in type 2 diabetes2018

    • Author(s)
      Natsuki Goto, Naoto Fujita, Tomoya Nakamura, Wataru Nino, Ryosuke Ochi, Susumu Urakawa
    • Organizer
      第95回日本生理学会(香川)
    • Related Report
      2017 Research-status Report
  • [Presentation] 運動の時間配分が肥満を伴う2型糖尿病ラットのブドウ糖負荷応答に及ぼす影響2017

    • Author(s)
      藤田直人、青野沙紀、 唐崎航平、世羅布実、黒瀬智之、 藤野英己、浦川将
    • Organizer
      第52回日本理学療法学術大会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2017-05-12
    • Related Report
      2016 Research-status Report
  • [Presentation] 運動の時間配分の違いが肥満を伴う2型糖尿病ラットの高インスリン血症に及ぼす影響2017

    • Author(s)
      藤田直人、青野沙紀、唐崎航平、世羅布実、黒瀬智之、藤野英己、浦川将
    • Organizer
      第28回広島スポーツ医学研究会
    • Place of Presentation
      広島県医師会館
    • Related Report
      2016 Research-status Report
  • [Remarks] 広島大学研究者総覧

    • URL

      http://seeds.office.hiroshima-u.ac.jp/profile/ja.5e006975e285125d520e17560c007669.html

    • Related Report
      2018 Annual Research Report 2016 Research-status Report
  • [Remarks] 広島大学研究者総覧 藤田直人

    • URL

      http://seeds.office.hiroshima-u.ac.jp/profile/ja.5e006975e285125d520e17560c007669.html

    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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